[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-411458-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-411458-en":131},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","intrapulmonary-schwannoma-a-rare-case-report-and-review-of-the-literature","Intrapulmonary Schwannoma - A Rare Case Report and Review of the Literature","","Schwannoma is a benign, well-circumscribed peripheral nerve sheath tumor arising from Schwann cells, typically growing slowly and behaving indolently. Primary pulmonary neuronal tumors are exceptionally rare (~0.2% of lung neoplasms) and are often misdiagnosed because radiologic findings are nonspecific. A 50-year-old man had an incidentally detected large cystic upper-lobe left lung mass after blunt chest trauma. Pathology showed encapsulated gelatinous cystic lesion with characteristic elongated wavy cells in a myxoid background. Considering schwannoma in differential diagnosis of well-defined encapsulated pulmonary masses supports accurate management.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/intrapulmonary-schwannoma-a-rare-case-report-and-review-of-the-literature/411458/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/intrapulmonary-schwannoma-a-rare-case-report-and-review-of-the-literature/411458.png","ImageObject",300,407,{"name":42,"@type":43},"eBook King","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-30","2026-09-28",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",13,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What is an intrapulmonary schwannoma, and why is it difficult to diagnose?","Question",{"text":63,"@type":64},"It is a benign peripheral nerve sheath tumor arising from Schwann cells. Diagnosis is challenging because primary pulmonary neuronal tumors are extremely rare and radiologic features are nonspecific.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"What clinical situation led to the discovery of the reported case?",{"text":68,"@type":64},"A 50-year-old man had a large cystic mass in the upper lobe of the left lung discovered incidentally on chest X-ray during workup after blunt chest trauma, without respiratory symptoms.",{"name":70,"@type":61,"acceptedAnswer":71},"What pathological findings support schwannoma in the case report?",{"text":72,"@type":64},"Microscopy showed hypo- and hypercellular areas with proliferation of elongated, wavy cells in a myxoid background, along with a well-circumscribed encapsulated creamy-gray cystic lesion.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},411458,1790618001,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,110,115,120,123,127],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":108,"slug":109},7,40,"healthcare",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":112,"show_sort_weight":113,"slug":114},8,"Research & Report",30,"research-report",{"id":116,"doc_module":4,"doc_module_name":25,"category_name":117,"show_sort_weight":118,"slug":119},9,"Religion & Spirituality",20,"religion-spirituality",{"id":118,"doc_module":4,"doc_module_name":25,"category_name":121,"show_sort_weight":118,"slug":122},"World Cup","world-cup",{"id":124,"doc_module":4,"doc_module_name":25,"category_name":125,"show_sort_weight":124,"slug":126},10,"Lifestyle","lifestyle",{"id":128,"doc_module":4,"doc_module_name":25,"category_name":129,"show_sort_weight":97,"slug":130},19,"General","general",{"code":4,"msg":82,"data":132},{"doc_id":79,"user_id":133,"nickname":42,"user_avatar":134,"doc_module":4,"category_id":107,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":107,"language":140,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":12,"update_tm":144,"read_time":145,"preview_page_count":4},962088006270,"https://ap-avatar.wpscdn.com/davatar_085a072bc5b1113ac321206ff7593b45","Intrapulmonary Schwannoma: A Rare Case Report and Review of the Literature  \nElham EntezarAlmahdi 1, Mehdi Jamalpour 1, Parviz Mardani2,3, Zahra Beyzaei4 and Bita Geramizadeh5  \nSage Open Pathology Volume 18: 1-7 © The Author(s) 2025 Article reuse guidelines:  \n[sagepub.com/journals-permissions](sagepub.com/journals-permissions)[ ](sagepub.com/journals-permissions)[DOI: 10.1177/30502098251410398](DOI: 10.1177/30502098251410398)[ ](DOI: 10.1177/30502098251410398)[journals.sagepub.com/home/pat](journals.sagepub.com/home/pat)  \nAbstract  \nSchwannoma is a benign, well-circumscribed, and encapsulated peripheral nerve sheath tumor that develops from Schwann cells. The growth pattern is usually slow, tending to clinical indolence. Primary pulmonary neuronal tumors are very rare, accounting for ~0.2% of all lung neoplasms, and are often misdiagnosed due to their nonspecific radiological features. A 50-year-old man presented with a large cystic mass in upper lobe of left lung discovered incidentally on chest X-ray during work up after a blunt chest trauma. Gross examination of the mass following surgical excision revealed a wellcircumscribed, encapsulated creamy-gray cystic lesion with gelatinous material measuring 10.5 × 6 × 5.5 cm, attached to a segment of lung. Microscopically, the tumor showed hypo-and hypercellular areas with proliferation of elongated wavy cells in a myxoid background which is characteristic of Schwannoma. Despite intrapulmonary schwannomas’ rarity, it is essential to consider schwannomas in the differential diagnosis of pulmonary masses, particularly when clinical and radiological findings suggest a well-defined, encapsulated lesion.  \nKeywords  \nlung neoplasms, intrapulmonary schwannomas, rare, tumors  \nReceived: 22 April 2025; accepted: 3 December 2025  \nIntroduction  \nSchwannoma is a benign, well-circumscribed, and encapsulated peripheral nerve sheath tumor that arises from Schwann cells.1 Macroscopically, these tumors typically appear as firm masses which may be round, ovoid, or lobulated and often exhibit a light-tan appearance surrounded by a fibrous capsule. They usually present as soft-tissue density on computed tomography (CT) .2 They generally exhibit slow growth and follow an indolent clinical course. Commonly, patients present with a slowly enlarging, painless mass, although neurological symptoms may occur depending on the specific nerve involvement.3 The majority of schwannomas are benign, and malignant transformation is exceedingly rare.3  \nSchwannomas most commonly occur in the head and neck regions, retroperitoneum, posterior mediastinum, and chest wall. However, schwannomas originating from the lung parenchyma or bronchial tree are extremely uncommon.4 Primary intrapulmonary neuronal tumors are very rare, accounting for ~0 .2% of all lung neoplasms.5  \nIn this report, we present an unusual case of a large, solid-cystic intrapulmonary schwannoma that was incidentally discovered in an asymptomatic patient.  \nCase Presentation  \nA 50-year-old, Iranian, non-smoker man without family history of neurofibromatosis was referred to cardiothoracic surgery clinic for evaluation of a large cystic mass in the upper lobe of the left lung, discovered incidentally during imaging after a blunt chest trauma. The patient did not have shortness of breath, pleuritic chest pain, tachypnea, or cough. On physical examination, lung auscultation and O2 saturation were normal. His laboratory investigations showed no abnormality.  \nHigh-resolution CT scan of the chest demonstrated an oval-shape hypoattenuating structure measuring  \n1 Department of Pathology, School of Medicine, Shiraz University of Medical Sciences, Iran  \n2Thoracic and Vascular Surgery Research Center, Shiraz University of Medical Sciences, Iran  \n3Department of Surgery, Shiraz University of Medical Sciences, Iran 4Transplant Research Center, Shiraz University of Medical Sciences, Iran 5Department of Pathology, Transplant Research Centre, Shiraz Universit","cbCaihMZOmTnfLQA","https://ap.wps.com/l/cbCaihMZOmTnfLQA","pdf",2150738,"English","# Abstract\n# Introduction\n# Case Presentation\n## Imaging and Clinical Findings\n## Surgical Treatment and Gross Findings\n## Microscopic Features and Diagnosis","[{\"question\":\"What is an intrapulmonary schwannoma, and why is it difficult to diagnose?\",\"answer\":\"It is a benign peripheral nerve sheath tumor arising from Schwann cells. Diagnosis is challenging because primary pulmonary neuronal tumors are extremely rare and radiologic features are nonspecific.\"},{\"question\":\"What clinical situation led to the discovery of the reported case?\",\"answer\":\"A 50-year-old man had a large cystic mass in the upper lobe of the left lung discovered incidentally on chest X-ray during workup after blunt chest trauma, without respiratory symptoms.\"},{\"question\":\"What pathological findings support schwannoma in the case report?\",\"answer\":\"Microscopy showed hypo- and hypercellular areas with proliferation of elongated, wavy cells in a myxoid background, along with a well-circumscribed encapsulated creamy-gray cystic lesion.\"}]","Intrapulmonary Schwannoma - A Rare Case Report and Review of the Literature | PDF",1790588600,18]