[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-377719-105":3,"doc-detail-377719-en":81,"detail-sidebar-cat-0-en-105":99},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","intraductal-oncocytic-papillary-neoplasm-iopn-two-case-reports-and-review-of-the-literature","Intraductal oncocytic papillary neoplasm (IOPN) - two case reports and review of the literature","","Intraductal oncocytic papillary neoplasm (IOPN) lies at the oncocytic end of the intraductal pancreatic neoplasm spectrum and shows characteristic morphologic features. Identification in 1996 and subsequent case accumulation have enabled refinement of diagnosis, clinical behavior, and biological hallmarks, including recurrent kinase gene rearrangements. Most IOPNs follow an indolent course and surgery is usually curative. Two adult male cases were managed with laparoscopic pancreatectomy without relapse on follow-up, and findings were compared with intraductal papillary mucinous neoplasms (IPMNs).",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/intraductal-oncocytic-papillary-neoplasm-iopn-two-case-reports-and-review-of-the-literature/377719/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/intraductal-oncocytic-papillary-neoplasm-iopn-two-case-reports-and-review-of-the-literature/377719.png","ImageObject",300,407,{"name":42,"@type":43},"Emma Wilson","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-28","2026-09-24",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",13,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What distinguishes intraductal oncocytic papillary neoplasms (IOPNs) from IPMNs microscopically?","Question",{"text":63,"@type":64},"IOPNs are distinguished by dysplastic oncocytic elements arranged in frondous papillae.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"What was the clinical course and treatment approach in the two reported cases?",{"text":68,"@type":64},"Both adult male patients had voluminous pancreatic masses and underwent laparoscopic pancreatectomy. Surgical margins were free of disease and neither patient experienced relapse during the reported follow-up periods.",{"name":70,"@type":61,"acceptedAnswer":71},"What key research directions does the paper highlight for IOPNs?",{"text":72,"@type":64},"The paper emphasizes further research to identify novel prognostic and predictive markers for oncocytic neoplasms, alongside ongoing characterization using immunohistochemical and molecular data.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},377719,1790309291,{"code":4,"msg":82,"data":83},"success",{"doc_id":79,"user_id":84,"nickname":42,"user_avatar":85,"doc_module":4,"category_id":86,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":87,"file_id":88,"file_url":89,"file_type":90,"file_size":91,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":92,"language":93,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":94,"faqs":95,"seo_title":96,"seo_description":12,"update_tm":97,"read_time":98},3848291630094,"https://eur-avatar.wpscdn.com/davatar_085a072bc5b1113ac321206ff7593b45",7,"Intraductal oncocytic papillary neoplasm (IOPN): two case reports and review of the literature  \nLorenzo Innocenti1^, Maria Isabella Rotondo2^, Francescamaria Donati3^, Ugo Boggi4, Daniela Campani1^  \n1Division of Pathology, Department of Surgical, Medical, Molecular Pathology and Critical Care Medicine, Pisa University Hospital, Pisa, Italy; 2Department of Surgical Pathology, University Hospital of Pisa, Pisa, Italy; 3Division of Diagnostic and Interventional Radiology, University Hospital of Pisa, Pisa, Italy; 4Division of General and Transplant Surgery, University of Pisa, Pisa, Italy  \nContributions: (I) Conception and design: L Innocenti, MI Rotondo, D Campani; (II) Administrative support: None; (III) Provision of study materials or patients: MI Rotondo, F Donati, U Boggi, D Campani; (IV) Collection and assembly of data: L Innocenti; (V) Data analysis and interpretation: L Innocenti, MI Rotondo, F Donati, D Campani; (VI) Manuscript writing: All Authors; (VII) Final approval of manuscript: All Authors. Correspondence to: Lorenzo Innocenti. Division of Pathology, Department of Surgical, Medical, Molecular Pathology and Critical Care Medicine, Pisa  \nUniversity Hospital, 56124 Pisa, Italy. Email: [innocenti693@gmail.com](innocenti693@gmail.com).  \nBackground: Intraductal oncocytic papillary neoplasms (IOPNs) place at the oncocytic extreme of the intraductal pancreatic neoplasm spectrum and display typical morphological features. Their identification in 1996 by Adsay et al. has been followed by a growing number of cases, paving the way for a deeper understanding of this underestimated entity. Contrarily to intraductal papillary mucinous neoplasms (IPMNs), most IOPNs run an indolent course and surgery is usually curative. Pancreatic IOPNs tend to develop from the main pancreatic duct (MPD) and their diagnosis is either incidental or subsequent to mass-related symptoms. Up to 30% of cases show concomitant areas of minimal stromal invasion and loco-regional or systemic spread are confined to a minority of cases. Biological hallmarks of IOPNs are being identified, including recurrent kinase gene rearrangements. Morphological and biological traits of IOPNs seem to overlap with those of other malignancies. A deeper understanding of these entities is needed in order to shed light upon the nature of pancreato-biliary oncocytic neoplasms. This case report describes two patients with a diagnosis of IOPN—one of them accounting for the largest IOPN ever described—and provides a brief  \nreview of recent discoveries on the subject.  \nCase Description: We describe two cases of IOPN occurring in adult male patients, respectively in their 60s and 70s. Both patients had unremarkable clinical history. In case 1 the diagnosis was coincidentalto a right renal colic; case 2 complained a right lumbar pain radiating to the homolateral groin. In both cases imaging analyses revealed a voluminous pancreatic mass, posing the indication to laparoscopic pancreatectomy. Gross and histological features were consistent with the diagnosis of IOPN. Surgical margin were free from disease and the patient did not undergo further treatment. After a 10-and 7-month follow-up  \nrespectively, patients did not experience relapse.  \nConclusions: Recent immunohistochemical (IHC) and molecular data reveal unique characteristics of IOPNs, highlighting the substantial differences from IPMNs. Further research is needed in order to identify  \nnovel prognostic and predictive markers applicable to oncocytic neoplasms of the pancreato-biliary tract.  \nKeywords: Intraductal oncocytic papillary neoplasm (IOPN); intraductal papillary mucinous neoplasm (IPMN);  \ncase report; pancreas; immunohistochemistry  \nSubmitted Aug 12, 2022. Accepted for publication Dec 20, 2022. Published online Mar 02, 2023.  \ndoi: 10.21037/tcr-22-2029  \nView this article at: [https://dx.doi.org/10.21037/tcr-22-2029](https://dx.doi.org/10.21037/tcr-22-2029)  \n^ ORCID: Lorenzo Innocenti, 0000-0001-6492-6951; ","cbCaiiALrWUwslB7","https://ap.wps.com/l/cbCaiiALrWUwslB7","pdf",1041251,10,"English","# Background\n# Case Description\n## Case 1 and Case 2\n# Conclusions\n# Highlight Box","[{\"question\":\"What distinguishes intraductal oncocytic papillary neoplasms (IOPNs) from IPMNs microscopically?\",\"answer\":\"IOPNs are distinguished by dysplastic oncocytic elements arranged in frondous papillae.\"},{\"question\":\"What was the clinical course and treatment approach in the two reported cases?\",\"answer\":\"Both adult male patients had voluminous pancreatic masses and underwent laparoscopic pancreatectomy. Surgical margins were free of disease and neither patient experienced relapse during the reported follow-up periods.\"},{\"question\":\"What key research directions does the paper highlight for IOPNs?\",\"answer\":\"The paper emphasizes further research to identify novel prognostic and predictive markers for oncocytic neoplasms, alongside ongoing characterization using immunohistochemical and molecular data.\"}]","Intraductal oncocytic papillary neoplasm (IOPN) - two case reports and review of the literature | PDF",1790226831,25,{"code":4,"msg":82,"data":100},[101,105,109,113,118,123,126,131,136,139,142],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":102,"show_sort_weight":103,"slug":104},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":106,"show_sort_weight":107,"slug":108},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":110,"show_sort_weight":111,"slug":112},"Exam",70,"exam",{"id":114,"doc_module":4,"doc_module_name":25,"category_name":115,"show_sort_weight":116,"slug":117},5,"Comic",60,"comic",{"id":119,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":121,"slug":122},6,"Technology",50,"technology",{"id":86,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":124,"slug":125},40,"healthcare",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":129,"slug":130},8,"Research & Report",30,"research-report",{"id":132,"doc_module":4,"doc_module_name":25,"category_name":133,"show_sort_weight":134,"slug":135},9,"Religion & Spirituality",20,"religion-spirituality",{"id":134,"doc_module":4,"doc_module_name":25,"category_name":137,"show_sort_weight":134,"slug":138},"World Cup","world-cup",{"id":92,"doc_module":4,"doc_module_name":25,"category_name":140,"show_sort_weight":92,"slug":141},"Lifestyle","lifestyle",{"id":143,"doc_module":4,"doc_module_name":25,"category_name":144,"show_sort_weight":114,"slug":145},19,"General","general"]