[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-384625-105":59,"doc-detail-384625-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","intestinal-vitamin-d-receptor-protects-against-extraintestinal-breast-cancer-tumorigenesis","Intestinal vitamin D receptor protects against extraintestinal breast cancer tumorigenesis","","The microbiota regulates intestinal and extraintestinal organ function and health, raising the question of an intestinal-microbiome-breast axis in breast cancer development. Vitamin D receptor (VDR) involves host factors and the human microbiome: Vdr variation shapes microbiota, while VDR deficiency drives dysbiosis. In DMBA-treated intestinal epithelial VDR knockout mice with dysbiosis, VDR deficiency increases susceptibility, gut permeability, tight-junction disruption, microbial translocation, inflammation, and tumor burden. Butyrate or Lactobacillus plantarum reduces tumors.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/intestinal-vitamin-d-receptor-protects-against-extraintestinal-breast-cancer-tumorigenesis/384625/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/intestinal-vitamin-d-receptor-protects-against-extraintestinal-breast-cancer-tumorigenesis/384625.png","ImageObject",300,407,{"name":92,"@type":93},"Hazel","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":52},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What hypothesis links intestinal VDR to breast cancer development?","Question",{"text":112,"@type":113},"The study hypothesizes that intestinal VDR protects hosts against tumorigenesis in the breast, mediated through host-microbiome interactions.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How does intestinal VDR deficiency affect breast cancer in the DMBA model?",{"text":117,"@type":113},"Intestinal epithelial VDR knockout mice with dysbiosis show increased susceptibility to DMBA-induced breast cancer, with microbiota profile shifts toward carcinogenesis.",{"name":119,"@type":110,"acceptedAnswer":120},"Which interventions reduced breast tumors in VDR-deficient mice?",{"text":121,"@type":113},"Treatment with the beneficial bacterial metabolite butyrate or the probiotic Lactobacillus plantarum reduced breast tumors, improved tight junctions, inhibited inflammation, and decreased breast Streptococcus levels.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},384625,1790465242,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":52,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},137441390410,"https://ap-avatar.wpscdn.com/avatar/2000252f4ab5702993?_k=1776741390130283984","Intestinal vitamin D receptor protects against extraintestinal breast cancer tumorigenesis  \nYong-Guo Zhang a, Yinglin Xia a, Jilei Zhang a, Shreya Deba, Shari Garrett a, and Jun Sun a,b,c,d  \na Division of Gastroenterology and Hepatology, Department of Medicine, University of Illinois Chicago, Chicago, IL, USA; bDepartment of Microbiology and Immunology, University of Illinois Chicago, Chicago, IL, USA; cUIC Cancer Center, University of Illinois Chicago, Chicago, IL, USA; dJesse Brown VA Medical Center Chicago, Chicago, IL, USA  \nABSTRACT  \nThe microbiota plays critical roles in regulating the function and health of the intestine and extraintestinal organs. A fundamental question is whether an intestinal-microbiome-breast axis exists during the development of breast cancer. If so, what are the roles of host factors? Vitamin D receptor (VDR) involves host factors and the human microbiome. Vdr gene variation shapes the human microbiome, and VDR deficiency leads to dysbiosis. We hypothesized that intestinal VDR protects hosts against tumorigenesis in the breast. We examined a 7,12-dimethylbenzanthracene (DMBA)-induced breast cancer model in intestinal epithelial VDR knockout (VDRΔIEC) mice with dysbiosis. We reported that VDRΔIEC mice with dysbiosis are more susceptible to breast cancer induced by DMBA. Intestinal and breast microbiota analysis showed that VDR deficiency leads toa bacterial profile shift from normal to susceptible to carcinogenesis. We found enhanced bacterial staining within breast tumors. At the molecular and cellular levels, we identified the mechanisms by which intestinal epithelial VDR deficiency led to increased gut permeability, disrupted tight junctions, microbial translocation, and enhanced inflammation, thus increasing tumor size and number in the breast. Furthermore, treatment with the beneficial bacterial metabolite butyrate orthe probiotic Lactobacillus plantarum reduced breast tumors, enhanced tight junctions, inhibited inflammation, increased butyryl-CoA transferase, and decreased levels of breast Streptococcus bacteria in VDRΔIEC mice. The gut microbiome contributes to the pathogenesis of diseases not only in the intestine but also in the breast. Our study provides insights into the mechanism by which intestinal VDR dysfunction and gut dysbiosis lead to a high risk of extraintestinal tumorigenesis. Gut-tumor-microbiome interactions represent a new target in the prevention and treatment of breast cancer.  \nARTICLE HISTORY  \nReceived 12 May 2022 Revised 17 March 2023 Accepted 3 April 2023  \nKEYWORDS  \nDysbiosis; breast cancer; barrier function;  \nbutyrate-producing bacteria; butyrate; inflammation; gut-breast-axis; Lactobacillus plantarum; probiotics; tight junctions; VDR  \nIntroduction  \nVitamin D is a group offat-soluble steroids responsible for multiple biological effects. The active form of vitamin D, in conjunction with its own receptor VDR, exerts important roles in modulating both mucosal immunity and normal growth of epithelia cells 1, 2. The dysregulation of the vitamin D/VDRis known to increase the risk of various human disorders3–5, including breast cancer6–9. The parallel appreciation of a role for VDR in cancer biology began approximately 3 decades ago, and an understanding of its actions in normal and malignant systems has subsequently increased 10.  \nThe VDR-dependent regulation of the gut microbiome in human and animal studies  \nrepresents a newly identified and highly significant role for VDR 11, 12. We have demonstrated that the variations in the human Vdr gene shape the gut microbiome and that VDR deletion leads to dysbiosis 12 . Our studies support the critical role of VDR in maintaining intestinal and microbial homeostasis 13–15. We established the first conditional deletion of intestinal epithelial VDR mouse model (VDRΔIEC ) and demonstrated that intestinal bacterial abundance and function are significantly altered in VDRΔIEC mice 11 , 16 . VDRΔIEC mice were also susceptible t","cbCaim4P38IyVYMr","https://ap.wps.com/l/cbCaim4P38IyVYMr","pdf",7731870,23,"English","# Abstract\n# Introduction\n## The VDR-dependent regulation of the gut microbiome\n# Article information","[{\"question\":\"What hypothesis links intestinal VDR to breast cancer development?\",\"answer\":\"The study hypothesizes that intestinal VDR protects hosts against tumorigenesis in the breast, mediated through host-microbiome interactions.\"},{\"question\":\"How does intestinal VDR deficiency affect breast cancer in the DMBA model?\",\"answer\":\"Intestinal epithelial VDR knockout mice with dysbiosis show increased susceptibility to DMBA-induced breast cancer, with microbiota profile shifts toward carcinogenesis.\"},{\"question\":\"Which interventions reduced breast tumors in VDR-deficient mice?\",\"answer\":\"Treatment with the beneficial bacterial metabolite butyrate or the probiotic Lactobacillus plantarum reduced breast tumors, improved tight junctions, inhibited inflammation, and decreased breast Streptococcus levels.\"}]","Intestinal vitamin D receptor protects against extraintestinal breast cancer tumorigenesis | PDF",1790264275,58]