[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-370619-105":59,"doc-detail-370619-en":131},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":124,"head_meta":126,"extra_data":128,"updated_unix":130},105,"en","intestinal-dysbiosis-and-colorectal-cancer-year-review","Intestinal Dysbiosis and Colorectal Cancer - Year Review","","Colorectal cancer (CRC) is a major cause of cancer morbidity and mortality worldwide, driving demand for effective prevention and treatment. Gut microbiota research highlights how dysbiosis—imbalance across bacteria, fungi, viruses, and metabolites—supports CRC through immune modulation, metabolic reprogramming, and genotoxic effects. Specific microbes and viral factors promote inflammation and immune evasion, while metabolites such as short-chain fatty acids and bile acids may influence risk and therapy. The review also addresses microbiota-targeted clinical applications, including biomarker-assisted diagnosis, next-generation probiotics, and microbiome-based interventions.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/intestinal-dysbiosis-and-colorectal-cancer-year-review/370619/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/intestinal-dysbiosis-and-colorectal-cancer-year-review/370619.png","ImageObject",300,407,{"name":92,"@type":93},"Fahsai","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-31","2026-09-23",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",17,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"How does gut dysbiosis contribute to colorectal cancer development?","Question",{"text":113,"@type":114},"Dysbiosis supports tumorigenesis by reshaping immune responses, driving metabolic reprogramming, and increasing genotoxic effects that promote CRC initiation and progression.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"Which types of gut microbes are implicated in CRC?",{"text":118,"@type":114},"The review highlights bacterial species (e.g., Fusobacterium nucleatum and enterotoxigenic Bacteroides fragilis), fungal agents such as Candida species, and viral factors including Epstein–Barr virus and human cytomegalovirus.",{"name":120,"@type":111,"acceptedAnswer":121},"What microbiota-targeted strategies are discussed for CRC care?",{"text":122,"@type":114},"Strategies include biomarker-assisted diagnosis, next-generation probiotics, and microbiome-based interventions, aiming for improved prevention, diagnostics, and personalized therapy.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},370619,1790336271,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":140,"language":141,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":142,"faqs":143,"seo_title":144,"seo_description":67,"update_tm":145,"read_time":146},549768702563,"https://ap-avatar.wpscdn.com/avatar/8000c4aa63b76e948b?x-image-process=image/resize,m_fixed,w_180,h_180&k=1786536092046926083","Year Review  \nIntestinal dysbiosis and colorectal cancer  \nZiran Kang1, Shanshan Jiang2, Jing-Yuan Fang1, Huimin Chen2  \n1Shanghai Institute of Digestive Disease, NHC Key Laboratory of Digestive Diseases, School of Medicine, Shanghai Jiao Tong University, Shanghai 200001, China; 2Division of Gastroenterology and Hepatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200001, China.  \nAbstract  \nColorectal cancer (CRC) is one of the leading causes of cancer-related morbidity and mortality worldwide, highlighting the urgent need for novel preventive and therapeutic strategies. Emerging research highlights the crucial role of the gut microbiota, including bacteria, fungi, viruses, and their metabolites, in the pathogenesis of CRC. Dysbiosis, characterized by an imbalance in microbial composition, contributes to tumorigenesis through immune modulation, metabolic reprogramming, and genotoxicity. Specific bacterial species, such as Fusobacterium nucleatum and enterotoxigenic Bacteroides fragilis, along with fungal agents like Candida species, have been implicated in CRC progression. Moreover, viral factors, including Epstein–Barr virus and human cytomegalovirus, are increasingly recognized for their roles in promoting inflammation and immune evasion. This review synthesizes the latest evidence on host–microbiome interactions in CRC, emphasizing microbial metabolites, such as short-chain fatty acids and bile acids, which may act as both risk factors and therapeutic agents. We further discuss the latest advances in microbiota-targeted clinical applications, including biomarker-assisted diagnosis, next-generation probiotics, and microbiome-based interventions. A deeper understanding of the role of gut microbiome in CRC pathogenesis could pave the way for diagnostic, preventive, and personalized therapeutic strategies.  \nKeywords: Colorectal cancer; Dysbiosis; Gut microbiota; Bacteria; Fungus; Viruses; Metabolites  \nIntroduction  \nColorectal cancer (CRC), the third most commonly diagnosed cancer in the world and the second leading cause of cancer-related death, presents a critical public health challenge. Nearly 1.9 million new cases are reported each year, with substantial disparities in outcomes between high- and low-resource settings. [1,2] CRC is amultifactorial disease driven by a combination of genetic predispositions, environmental factors, and living habits. Major risk factors include high-fat, low-fiber diets, sedentary lifestyles, smoking, excessive alcohol consumption, and obesity. [3,4] Although current prevention strategies focus on lifestyle changes, screening programs, and early intervention through polypectomy, the study of gut microbiota has a new insight into the pathogenesis of CRC.  \nThe human intestinal microbiota, comprising trillions of microorganisms, including bacteria, fungi, viruses, and archaea, plays a fundamental role in maintaining intestinal homeostasis and influencing immune function. [5] Dysbiosis—an imbalance in microbial composition—has been implicated in the initiation and progression of CRC. [6] Studies have shown that germ-free mice develop significantly fewer intestinal tumors compared to  \n\n| Access this article online |  |\n| --- | --- |\n| Quick Response Code: | Website:\u003Cbr>[www.cmj.org](www.cmj.org) |\n|  | DOI:\u003Cbr>10.1097/CM9.0000000000003617 |\n\nconventionally raised counterparts, emphasizing the critical role of microbes in CRC development. [7] Specific bacterial taxa, such as Fusobacterium nucleatum (F. nucleatum) and Bacteroides fragilis (B. fragilis), have been associated with pro-tumorigenic activities, while others, including Akkermansia muciniphila (A. muciniphila) and Faecalibacterium prausnitzii (F. prausnitzii), exhibit protective effects. [8] Beyond bacteria, fungi, and viruses, especially bacteriophages, also play an emerging role in CRC, with evidence showing their involvement in microbial dysbiosis and inflammatory pathways. [9] Moreover, microbial m","cbCaiglM2BNutyKE","https://ap.wps.com/l/cbCaiglM2BNutyKE","pdf",3266323,22,"English","# Introduction\n# Bacterial Dysbiosis in CRC\n# Host–Microbiome Interactions in CRC\n## Microbial metabolites and mechanisms\n## Microbiota-targeted clinical applications","[{\"question\":\"How does gut dysbiosis contribute to colorectal cancer development?\",\"answer\":\"Dysbiosis supports tumorigenesis by reshaping immune responses, driving metabolic reprogramming, and increasing genotoxic effects that promote CRC initiation and progression.\"},{\"question\":\"Which types of gut microbes are implicated in CRC?\",\"answer\":\"The review highlights bacterial species (e.g., Fusobacterium nucleatum and enterotoxigenic Bacteroides fragilis), fungal agents such as Candida species, and viral factors including Epstein–Barr virus and human cytomegalovirus.\"},{\"question\":\"What microbiota-targeted strategies are discussed for CRC care?\",\"answer\":\"Strategies include biomarker-assisted diagnosis, next-generation probiotics, and microbiome-based interventions, aiming for improved prevention, diagnostics, and personalized therapy.\"}]","Intestinal Dysbiosis and Colorectal Cancer - Year Review | PDF",1790189498,55]