[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-329956-105":59,"doc-detail-329956-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","interplay-of-oxidative-stress-cellular-communication-and-signaling-pathways-in-cancer","Interplay of oxidative stress, cellular communication and signaling pathways in cancer","","Cancer remains a major global public health challenge, with rising incidence and mortality worldwide. Oxidative stress, driven by reactive oxygen species (ROS) production, shapes cancer development by altering genomic stability and signaling within the cellular microenvironment. Excess ROS disrupts homeostasis, driving loss of normal functions and influencing downstream pathways central to carcinogenesis, including p53, Keap1-NRF2, and cell-cycle and tumor-suppressor networks. Targeting oxidative stress and restoring redox balance may improve therapy efficacy and patient outcomes through antioxidant and redox-modulating interventions.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/interplay-of-oxidative-stress-cellular-communication-and-signaling-pathways-in-cancer/329956/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/interplay-of-oxidative-stress-cellular-communication-and-signaling-pathways-in-cancer/329956.png","ImageObject",300,407,{"name":92,"@type":93},"Jiven","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-14","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":39},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"How does oxidative stress contribute to cancer development?","Question",{"text":112,"@type":113},"Oxidative stress increases reactive oxygen species (ROS), which disrupt cellular homeostasis and can damage DNA, proteins, and lipids, promoting genetic instability and malignant tumor development.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Which signaling pathways are highlighted as affected by oxidative stress?",{"text":117,"@type":113},"The review focuses on downstream pathways influenced by oxidative stress, including p53, Keap1–NRF2, RB1, p21, APC, tumor suppressor genes, and cell type transitions.",{"name":119,"@type":110,"acceptedAnswer":120},"What therapeutic strategies are discussed for targeting oxidative stress in cancer?",{"text":121,"@type":113},"Therapeutic approaches aim to limit oxidative-stress responses and restore redox balance, potentially improving cancer treatment efficacy through antioxidant-based treatments, redox-modulating agents, and interventions that normalize affected signaling pathways.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},329956,1790492158,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":39,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":36,"preview_page_count":4},1099513958607,"https://ap-avatar.wpscdn.com/avatar/100002390cf8733938c?x-image-process=image/resize,m_fixed,w_180,h_180&k=1778829742770036399","Iqbal et al. Cell Communication and Signaling (2024) 22:7  \n[https://doi.org/10.1186/s12964-023-01398-5](https://doi.org/10.1186/s12964-023-01398-5)  \nCell Communication and Signaling  \n REVIEW Open Access  \nInterplay of oxidative stress, cellular communication and signaling pathways in cancer  \nMuhammad Javed Iqbal 1, Ayesha Kabeer 1,2, Zaighum Abbas1, Hamid Anees Siddiqui1, Daniela Calina3*, Javad Sharifi‑Rad4* and William C. Cho5*  \nAbstract  \nCancer remains a significant global public health concern, with increasing incidence and mortality rates worldwide. Oxidative stress, characterized by the production of reactive oxygen species (ROS) within cells, plays a critical role in the development of cancer by affecting genomic stability and signaling pathways within the cellular microenvi‑ ronment. Elevated levels of ROS disrupt cellular homeostasis and contribute to the loss of normal cellular functions, which are associated with the initiation and progression of various types of cancer. In this review, we have focused on elucidating the downstream signaling pathways that are influenced by oxidative stress and contribute to carcino‑ genesis. These pathways include p53, Keap1‑NRF2, RB1, p21, APC, tumor suppressor genes, and cell type transitions. Dysregulation of these pathways can lead to uncontrolled cell growth, impaired DNA repair mechanisms, and eva‑ sion of cell death, all of which are hallmark features of cancer development. Therapeutic strategies aimed at target‑ ing oxidative stress have emerged as a critical area of investigation for molecular biologists. The objective is to limit the response time of various types of cancer, including liver, breast, prostate, ovarian, and lung cancers. By modulating the redox balance and restoring cellular homeostasis, it may be possible to mitigate the damaging effects of oxida‑ tive stress and enhance the efficacy of cancer treatments. The development of targeted therapies and interventions that specifically address the impact of oxidative stress on cancer initiation and progression holds great promise in improving patient outcomes. These approaches may include antioxidant‑based treatments, redox‑modulating agents, and interventions that restore normal cellular function and signaling pathways affected by oxidative stress. In summary, understanding the role of oxidative stress in carcinogenesis and targeting this process through therapeutic interventions are of utmost importance in combating various types of cancer. Further research is needed to unravel the complex mechanisms underlying oxidative stress‑related pathways and to develop effective strategies that can be translated into clinical applications for the management and treatment of cancer.  \nKeywords Oxidative stress, Reactive oxygen species, Cancer, Carcinogenesis mechanisms  \n*Correspondence:  \nDaniela Calina[calinadaniela@gmail.com](calinadaniela@gmail.com)[ ](calinadaniela@gmail.com)Javad Sharifi‑Rad [javad.sharifirad@gmail.com](javad.sharifirad@gmail.com)[ ](javad.sharifirad@gmail.com)William C. Cho [chocs@ha.org.hk](chocs@ha.org.hk)  \nFull list of author information is available at the end of the article  \n© The Author(s) 2023. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit ","cbCaibqRa5b7xEEj","https://ap.wps.com/l/cbCaibqRa5b7xEEj","pdf",1726884,16,"English","# Abstract\n# Keywords\n# Introduction","[{\"question\":\"How does oxidative stress contribute to cancer development?\",\"answer\":\"Oxidative stress increases reactive oxygen species (ROS), which disrupt cellular homeostasis and can damage DNA, proteins, and lipids, promoting genetic instability and malignant tumor development.\"},{\"question\":\"Which signaling pathways are highlighted as affected by oxidative stress?\",\"answer\":\"The review focuses on downstream pathways influenced by oxidative stress, including p53, Keap1–NRF2, RB1, p21, APC, tumor suppressor genes, and cell type transitions.\"},{\"question\":\"What therapeutic strategies are discussed for targeting oxidative stress in cancer?\",\"answer\":\"Therapeutic approaches aim to limit oxidative-stress responses and restore redox balance, potentially improving cancer treatment efficacy through antioxidant-based treatments, redox-modulating agents, and interventions that normalize affected signaling pathways.\"}]","Interplay of oxidative stress, cellular communication and signaling pathways in cancer | PDF",1789986307]