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This review analyzes lung and colorectal cancer signaling pathways influenced by bioactive compounds from eleven traditional medicinal plants, selected from documented traditional use, scoping-review evidence, and literature on anticancer activity. It summarizes isolated phytoconstituents that modulate PI3K/Akt/mTOR, RAS/RAF/MAPK, Wnt/β-catenin, and TGF-β pathways, and highlights curcumin- and baicalin-linked preclinical promise, clinical trials, and miRNA pathway regulation.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/interplay-between-traditional-and-scientific-knowledge-phytoconstituents-and-their-roles-in-lung-and-colorectal-cancer-signaling-pathways/367283/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/interplay-between-traditional-and-scientific-knowledge-phytoconstituents-and-their-roles-in-lung-and-colorectal-cancer-signaling-pathways/367283.png","ImageObject",300,407,{"name":92,"@type":93},"Aurelia","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-23",true,{"@type":102,"interactionType":103,"userInteractionCount":52},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Which cancer types and signaling pathways does the review focus on?","Question",{"text":112,"@type":113},"The review focuses on lung and colorectal cancers and summarizes signaling pathways modulated by phytoconstituents, including PI3K/Akt/mTOR, RAS/RAF/MAPK, Wnt/β-catenin, and TGF-β.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How were the eleven traditional medicinal plants selected?",{"text":117,"@type":113},"Selection used cross-referencing from a scoping review of traditional cancer treatments, an international survey of herbal medicine used for lung and colorectal cancer management, and availability of existing literature on anticancer properties.",{"name":119,"@type":110,"acceptedAnswer":120},"What are the challenges and potential strategies mentioned for curcumin and baicalin?",{"text":121,"@type":113},"Curcumin and baicalin show preclinical effectiveness but face bioavailability challenges; the review discusses possible solutions such as combining with piperine or using oral extracts to enhance gut microbiome conversion.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},367283,1790227395,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":52,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},1099514068365,"https://ap-avatar.wpscdn.com/avatar/10000253d8d9f28188e?_k=1776742907772140068","Review  \nInterplay Between Traditional and Scientific Knowledge: Phytoconstituents and Their Roles in Lung and Colorectal Cancer Signaling Pathways  \nIlma Imtiaz , Janet Schloss  and Andrea Bugarcic *  \nAcademic Editor: Seungtae Kim  \nReceived: 21 January 2025  \nRevised: 27 February 2025  \nAccepted: 27 February 2025  \nPublished: 5 March 2025  \nCitation: Imtiaz, I.; Schloss, J.; Bugarcic, A. Interplay Between Traditional and Scientific Knowledge:  \nPhytoconstituents and Their Roles in Lung and Colorectal Cancer Signaling Pathways. Biomolecules 2025, 15, 380 . [https://doi.org/10.3390/](https://doi.org/10.3390/)[ ](https://doi.org/10.3390/)biom15030380  \nCopyright: © 2025 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://creativecommons.org/](https://creativecommons.org/)[ ](https://creativecommons.org/)[licenses/by/4.0/](licenses/by/4.0/)) .  \nNational Centre for Naturopathic Medicine, Faculty of Health, Southern Cross University, Military Road,  \nLismore, NSW 2480, Australia; [i.imtiaz.11@student.scu.edu.au](i.imtiaz.11@student.scu.edu.au) (I.I.); [janet.schloss@scu.edu.au](janet.schloss@scu.edu.au) (J.S.)  \n* Correspondence: [andrea.bugarcic@scu.edu.au](andrea.bugarcic@scu.edu.au)  \nAbstract: Natural plant products have been used for cancer treatment since ancient times and continue to play a vital role in modern anticancer drug development. However, only a small fraction of identified medicinal plants has been thoroughly investigated, particularly for their effects on cellular pathways in lung and colorectal cancers, two under-researched cancers with poor prognostic outcomes (lung cancers) . This review focuses on the lung and colorectal cancer signaling pathways modulated by bioactive compounds from eleven traditional medicinal plants: Curcuma longa, Astragalus membranaceus, Glycyrrhiza glabra, Althaea officinalis, Echinacea purpurea, Sanguinaria canadensis, Codonopsis pilosula, Hydrastis canadensis, Lobelia inflata, Scutellaria baicalensis, and Zingiber officinale. These plants were selected based on their documented use in traditional medicine and modern clinical practice. Selection criteria involved cross-referencing herbs identified in a scoping review of traditional cancer treatments and findings from an international survey on herbal medicine currently used for lung and colorectal cancer management by our research group and the availability of existing literature on their anticancer properties. The review identifies several isolated phytoconstituents from these plants that exhibit anticancer properties by modulating key signaling pathways such as PI3K/Akt/mTOR, RAS/RAF/MAPK, Wnt/β-catenin, and TGF-β in vitro. Notable constituents include sanguinarine, berberine, hydrastine, lobeline, curcumin, gingerol, shogaol, caffeic acid, echinacoside, cichoric acid, glycyrrhizin, 18-β-glycyrrhetinic acid, astragaloside IV, lobetyolin, licochalcone A, baicalein, baicalin, wogonin, and glycyrol. Curcumin and baicalin show preclinical effectiveness but face bioavailability challenges, which may be overcome by combining them with piperine or using oral extracts to enhance gut microbiome conversion, integrating traditional knowledge with modern strategies for improved outcomes. Furthermore, herbal extracts from Echinacea, Glycyrrhiza, and Codonopsis, identified in traditional knowledge, are currently in clinical trials. Notably, curcumin and baicalin also modulate miRNA pathways, highlighting a promising intersection of modern science and traditional medicine. Thus, the development of anticancer therapeutics continues to benefit from the synergy of traditional knowledge, scientific innovation, and technological advancements.  \nKeywords: cancer; traditional medicine; phytocompounds; phytoconstituents; signaling pathways; herbal medicine  \n1. Introduction  \nCancer is a significant global health","cbCaieXxV867iggb","https://ap.wps.com/l/cbCaieXxV867iggb","pdf",1979117,33,"English","# Introduction\n# Abstract\n# Keywords","[{\"question\":\"Which cancer types and signaling pathways does the review focus on?\",\"answer\":\"The review focuses on lung and colorectal cancers and summarizes signaling pathways modulated by phytoconstituents, including PI3K/Akt/mTOR, RAS/RAF/MAPK, Wnt/β-catenin, and TGF-β.\"},{\"question\":\"How were the eleven traditional medicinal plants selected?\",\"answer\":\"Selection used cross-referencing from a scoping review of traditional cancer treatments, an international survey of herbal medicine used for lung and colorectal cancer management, and availability of existing literature on anticancer properties.\"},{\"question\":\"What are the challenges and potential strategies mentioned for curcumin and baicalin?\",\"answer\":\"Curcumin and baicalin show preclinical effectiveness but face bioavailability challenges; the review discusses possible solutions such as combining with piperine or using oral extracts to enhance gut microbiome conversion.\"}]","Interplay Between Traditional and Scientific Knowledge - Phytoconstituents and Their Roles in Lung and Colorectal Cancer Signaling Pathways | PDF",1790170079,83]