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The PI3K/AKT signaling pathway governs key cellular processes including proliferation, invasion, migration, and angiogenesis. The lncRNA/PI3K/AKT axis regulates cancer-related gene expression, links dysregulated lncRNA patterns to clinicopathological features, and supports tumor progression. This review summarizes PI3K/AKT-related lncRNA expression and functions in vitro and in vivo, evaluates correlations with clinicopathological features, and provides theoretical support for clinical diagnosis and efficacy monitoring in digestive system neoplasms.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/interplay-between-lncrnas-and-the-pi3kakt-signaling-pathway-in-the-progression-of-digestive-system-neoplasms-review/331531/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/interplay-between-lncrnas-and-the-pi3kakt-signaling-pathway-in-the-progression-of-digestive-system-neoplasms-review/331531.png","ImageObject",300,407,{"name":92,"@type":93},"Quinn","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-25","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":24},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"How do lncRNAs regulate gene expression in this review?","Question",{"text":112,"@type":113},"lncRNAs regulate expression by interacting with DNA, RNA, and proteins, affecting mRNA splicing, stabilization, translation, and degradation. They can also function as competing endogenous RNAs that bind microRNAs to modulate mRNA expression.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What role does the PI3K/AKT signaling pathway play in tumor progression?",{"text":117,"@type":113},"The review describes PI3K/AKT as a central intracellular signaling pathway that drives processes such as cell proliferation, invasion, migration, and angiogenesis. Abnormal pathway activity contributes to tumor development.",{"name":119,"@type":110,"acceptedAnswer":120},"What is the clinical relevance of the lncRNA/PI3K/AKT axis in digestive system neoplasms?",{"text":121,"@type":113},"Dysregulated lncRNA expression within the lncRNA/PI3K/AKT axis is linked to clinicopathological features and is important for regulating biological functions relevant to tumor progression. The review also emphasizes potential value for diagnosis and efficacy monitoring through biomarkers.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},331531,1790171472,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":24,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},962075114765,"https://ap-avatar.wpscdn.com/davatar_a8503ba1806abce46bf441b54a3ca4cd","INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 55: 15, 2025  \nInterplay between lncRNAs and the PI3K/AKT signaling pathway in the progression of digestive system neoplasms (Review)  \nXIAOYU ZHANG 1 , LEI SHI2 , MENGZHEN XING2 , CHUNJING LI 1 ,  \nFENGJUN MA 1 , YUNING MA2 and YUXIA MA 1  \n1  \nDepartment of Acupuncture and Massage College, Shandong University of Traditional Chinese Medicine, Jinan, Shandong 250000, P.R. China; 2Key Laboratory of New Material Research Institute, Institute of Pharmaceutical Research, Shandong University of Traditional Chinese Medicine, Jinan, Shandong 250000, P.R. China  \nReceived September 3, 2024; Accepted October 29, 2024  \nDOI: 10.3892/ijmm.2024.5456  \nAbstract. Long non‑coding RNA (lncRNA) is a class of non‑coding RNA molecules located in the cytoplasm or nucleus, which can regulate chromosome structure and function by interacting with DNA, RNA, proteins and other molecules; binding to mRNA bases in a complementary manner, affecting the splicing, stabilization, translation and degradation of mRNA; acting as competing endogenous RNA competitively binds to microRNAs to regulate gene expres‑ sion and participate in the regulation of various vital activities of the body. The PI3K/AKT signalling pathway plays a key role in numerous biological and cellular processes, such as cell proliferation, invasion, migration and angiogenesis. It has been found that the lncRNA/PI3K/AKT axis regulates the expression of cancer‑related genes and thus tumour progres‑ sion. The abnormal regulation of lncRNA expression in the lncRNA/PI3K/AKT axis is clearly associated with clinico‑ pathological features and plays an important role in regulating biological functions . In the present review, the expression and biological functions of PI3K/AKT‑related lncRNAs both in vitro and in vivo over recent years, were comprehensively summarized and analyzed. Their correlation with clinico‑ pathological features was also evaluated, with the objective of furnishing a solid theoretical foundation for clinical diagnosis  \nCorrespondence to: Professor Yuning Ma, Key Laboratory of New Material Research Institute, Institute of Pharmaceutical Research, Shandong University of Traditional Chinese Medicine, 4655 University Road, Changqing, Jinan, Shandong 250000, P.R. China  \nE‑mail: [60210001@sdutcm.edu.cn](60210001@sdutcm.edu.cn)  \nProfessor Yuxia Ma, Department of Acupuncture and Massage College, Shandong University of Traditional Chinese Medicine, 4655 University Road, Changqing, Jinan, Shandong 250000, P.R. China  \nE‑[mail: myxia1976@163.com](mail: myxia1976@163.com)  \nKey words: long non‑coding RNA, PI3K, AKT, digestive system neoplasms, biomarker  \nand the monitoring of efficacy in digestive system neoplasms. The present review aimed to provide a comprehensive overview of the expression and biological functions of PI3K/AKT‑related lncRNAs in digestive system neoplasms and to assess their correlation with clinicopathological features. This endeavor seeks to establish a solid theoretical foundation for the clinical diagnosis and efficacy monitoring of digestive system tumors.  \nContents  \n1. Introduction  \n2. Mechanism of action of lncRNA  \n3. The PI3K/AKT signaling pathway in tumorigenesis  \n4. The lncRNA/PI3K/AKT axis in cancer  \n5. Cell biological functions related to the lncRNA/PI3K/AKTaxis in digestive system neoplasms  \n6. lncRNAs related to the PI3K/AKT pathway as biomarkers  \n7. Conclusion  \n1. Introduction  \nCancer is one of the primary lethal factors in the world today. According to the latest data, the number of newly diagnosed cancers worldwide is projected to achieve 28.4 million (1) . Furthermore, it has become an important public health concern that severely affects the lives of patients (2,3) . Specifically, digestive system neoplasms represent a hetero‑ geneous group of cancers characterized by diverse symptoms and complexities in diagnosis and treatment. Prognosis is often poor and influenced by various factors, highlig","cbCaioUP4ntCSU6r","https://ap.wps.com/l/cbCaioUP4ntCSU6r","pdf",3823226,18,"English","# Introduction\n## Mechanism of action of lncRNA\n## The PI3K/AKT signaling pathway in tumorigenesis\n## The lncRNA/PI3K/AKT axis in cancer\n## Cell biological functions related to the lncRNA/PI3K/AKT axis in digestive system neoplasms\n## lncRNAs related to the PI3K/AKT pathway as biomarkers\n## Conclusion","[{\"question\":\"How do lncRNAs regulate gene expression in this review?\",\"answer\":\"lncRNAs regulate expression by interacting with DNA, RNA, and proteins, affecting mRNA splicing, stabilization, translation, and degradation. They can also function as competing endogenous RNAs that bind microRNAs to modulate mRNA expression.\"},{\"question\":\"What role does the PI3K/AKT signaling pathway play in tumor progression?\",\"answer\":\"The review describes PI3K/AKT as a central intracellular signaling pathway that drives processes such as cell proliferation, invasion, migration, and angiogenesis. Abnormal pathway activity contributes to tumor development.\"},{\"question\":\"What is the clinical relevance of the lncRNA/PI3K/AKT axis in digestive system neoplasms?\",\"answer\":\"Dysregulated lncRNA expression within the lncRNA/PI3K/AKT axis is linked to clinicopathological features and is important for regulating biological functions relevant to tumor progression. The review also emphasizes potential value for diagnosis and efficacy monitoring through biomarkers.\"}]","Interplay between lncRNAs and the PI3K/AKT signaling pathway in the progression of digestive system neoplasms - Review | PDF",1789993775,45]