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Ten patients underwent hyaluronic-acid lip filler injection using a modified technique with a 27-gauge 25 mm micro-cannula between 2021 and 2023. 3D scans were collected at baseline and multiple follow-ups (T0–T5) and scored by three blinded orthodontic specialists using two classification systems. Results showed high interobserver agreement, supporting reliable outcome assessment, with suggested refinements for consistency.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/interobserver-reliability-in-the-3d-facial-scan-assessment-of-the-outcome-in-dermal-filler-therapy-research-open-access/446328/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/interobserver-reliability-in-the-3d-facial-scan-assessment-of-the-outcome-in-dermal-filler-therapy-research-open-access/446328.png","ImageObject",300,407,{"name":92,"@type":93},"Rizky","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-03","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":34},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What does the study evaluate in dermal filler therapy after oral cleft treatment?","Question",{"text":112,"@type":113},"It evaluates interobserver reliability of two different assessment methods for 3D facial scan data used to assess therapeutic outcomes.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How were patients treated and when were scans performed?",{"text":117,"@type":113},"Ten oral-cleft patients received hyaluronic-acid filler in the oral region between 2021 and 2023, and 3D facial scans were taken at multiple timepoints from before injection through follow-ups (T0–T5).",{"name":119,"@type":110,"acceptedAnswer":120},"Who assessed the 3D images and what were they blinded to?",{"text":121,"@type":113},"Three experienced orthodontic specialists scored the images using two classification systems, blinded to clinical data and outcome.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},446328,1790767741,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":34,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":39,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":46,"preview_page_count":4},962085564807,"https://ap-avatar.wpscdn.com/davatar_6f874abed73319feea01a86fa6f0fab8","Vadasz etal. Head & Face Medicine (2026) 22:1 Head & Face Medicine  \n[https://doi.org/10.1186/s13005-025-00562-1](https://doi.org/10.1186/s13005-025-00562-1)  \nRESEARCH Open Access  \nInterobserver reliability in the 3D facial scan assessment of the outcome in dermal filler therapy  \nAnna Vadasz 1*, Mate Vlocsko 1, Tamas Tarjanyi 1, Ferenc Rarosi 1, Tamas Vereb 1, Anna Lili Zicsi-Liess 1, Laszlo Hegedus 1, Veronika Agnes Jancsik 1 and Jozsef Piffko 1  \nAbstract  \nStudy design We conducted a prospective cohort study comparing interobserver reliability of 2 different 3D scanning measurement methods following dermal filler therapy in oral cleft patients.  \nObjective of the study The objective of the study was to compare the interobserver reliability of 2 different assessment methods of 3D facial scan data.  \nMethods We studied 10 oral-cleft patients prospectively who underwent dermal filler therapy in the oral region by a single oral-surgeon using a modified injecting technique with 27 gauge 25 mm micro-cannula between 2021 and 2023. 3D facial scans were made before the treatment procedure and during follow-up visits and were used for analysis. The interbody fusion was scored on these 3D images using the 2 classification systems (Method 1, Method 2) by 3 experienced orthodontic specialists all of whom were blinded to clinical data and outcome.  \nResults Of the 2 classifications included in the current study, all classifications had a high interobserver agreement. Conclusion The 2 assessment methods used in this study showed high interobserver reliability so we can conclude that, the applied methods may provide as a validation in the outcome of dermal filler therapy. However, we suggest that further refinements may be required to achieve a reliable and consistent assessment of 3D facial scan analysis after dermal filler therapy in oral cleft patients.  \nKeywords Orofacial clefts, Dermal filler, 3D facial scanning, Interobserver reliability  \n*Correspondence:  \nAnna Vadasz  \n[vadaszanna5@gmail.com](vadaszanna5@gmail.com)  \n1University of Szeged, Szeged, Hungary  \n© The Author(s) 2025. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit [http://creativecommons.org/l](http://creativecommons.org/l)icenses/by/4.0/.  \nVadasz et al. Head & Face Medicine (2026) 22:1 Page 2 of 8  \nFig. 1 Preoperative and postoperative photo of lip filler therapy  \nIntroduction  \nA crucial aspect in the outcome of clinical research lies in data obtained from observational measures. Especially when developing new therapeutic approaches, the outcomes must be reliable and reproducible.  \nIn this study, we present a safe and effective technique for lip augmentation with hyaluronic acid in patients with cleft lip scars.  \nThe overall aim of this study was to understand how we can positively impact the lives of individuals with cleft lipscars and evaluate the dynamic outcomes of hyaluronic acid filler therapy.  \nDuring the last decades, the number of dermal filler procedures performed has increased exponentially. The importance of reliable measurement systems is becoming more and more evident [1], not only to objectively quantify therapeutic results, but also to record patient satisfactory data comparing the accomplished qua","cbCaiklgIZd6QEEq","https://ap.wps.com/l/cbCaiklgIZd6QEEq","pdf",1576317,"English","# Abstract\n## Study design and objective\n## Methods\n## Results and conclusion\n# Introduction\n# Materials and methods\n## Study design and population\n## Imaging protocols of the facial scans","[{\"question\":\"What does the study evaluate in dermal filler therapy after oral cleft treatment?\",\"answer\":\"It evaluates interobserver reliability of two different assessment methods for 3D facial scan data used to assess therapeutic outcomes.\"},{\"question\":\"How were patients treated and when were scans performed?\",\"answer\":\"Ten oral-cleft patients received hyaluronic-acid filler in the oral region between 2021 and 2023, and 3D facial scans were taken at multiple timepoints from before injection through follow-ups (T0–T5).\"},{\"question\":\"Who assessed the 3D images and what were they blinded to?\",\"answer\":\"Three experienced orthodontic specialists scored the images using two classification systems, blinded to clinical data and outcome.\"}]","Interobserver reliability in the 3D facial scan assessment of the outcome in dermal filler therapy - Research Open Access | PDF",1790714971]