[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-428250-105":59,"doc-detail-428250-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","interferon-release-assay-control-results-are-associated-with-all-cause-mortality-abstract","INTERFERON-Γ RELEASE ASSAY CONTROL RESULTS ARE ASSOCIATED WITH ALL-CAUSE MORTALITY - Abstract","","Impaired immune responses are a key feature of aging, yet no clinical tests of immune function are established. Interferon-gamma release assays (IGRAs) for tuberculosis screening may provide a functional immune measure by quantifying interferon-gamma release from T-cells and using the mitogen-nil difference to assess test validity. Using all negative and indeterminate IGRA results from 16,105 outpatients, Cox regression evaluates associations with mortality at 6 months, 1 year, and 5 years. Higher mitogen-nil values show lower mortality hazard, including after adjustment for demographics, frailty, and area deprivation index.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/interferon-release-assay-control-results-are-associated-with-all-cause-mortality-abstract/428250/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/interferon-release-assay-control-results-are-associated-with-all-cause-mortality-abstract/428250.png","ImageObject",300,407,{"name":92,"@type":93},"Stanford","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-08","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":34},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What immune function measure is evaluated in this study?","Question",{"text":112,"@type":113},"The study evaluates interferon-gamma release assays (IGRAs), focusing on the mitogen-nil difference that reflects T-cell function and test validity.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How was the study sample selected?",{"text":117,"@type":113},"All negative and indeterminate IGRA tests were obtained from a large health system, and the sample was limited to the most recent outpatient test results, excluding people receiving hemodialysis or immunosuppressive medications.",{"name":119,"@type":110,"acceptedAnswer":120},"What is the relationship between mitogen-nil values and mortality?",{"text":121,"@type":113},"Greater T-cell responses to mitogen stimulation are associated with a lower hazard of all-cause mortality at 6 months, 1 year, and 5 years, with results persisting after adjustments for age, sex, frailty, and area deprivation index.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},428250,1790790023,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":34,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":8,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":81,"preview_page_count":4},2336477552062,"https://ap-avatar.wpscdn.com/davatar_994ba38a5ba835b3df7d355c54d3ed8d","1074 Innovation in Aging, 2025, Vol. 9, No. S2  \nAbstract citation ID: igaf122.3611  \nINTERFERON-Γ RELEASE ASSAY CONTROL RESULTS ARE ASSOCIATED WITH ALL-CAUSE MORTALITY  \nBenjamin Seligman1, David Ganz2, Matthew Goetz2, and David Beenhouwer3, 1. UCLA School of Medicine, Los Angeles, California, United States, 2. VA Greater Los Angeles Healthcare System, Los Angeles, California, United States, 3. University of California, Los Angeles, Los Angeles, California, United States  \nImpaired immune responses are a key feature of aging.  \nHowever, there are no clinical tests of immune function.  \nInterferon-gamma release assays (IGRAs) for tuberculosis screening may provide such a measure. We assess this measure’s relationship with all-cause mortality. IGRAs quantify release of interferon-gamma by T-cells and the difference between unstimulated and mitogen-stimulated T-cells is assessed for test validity.  \nThis mitogen-nil difference capturesT-cell function. We obtained all negative and indeterminate IGRA tests from a large health system along with demographics, frailty, and area deprivation index (ADI) data. We limited our sample to the most recent test given to outpatients not receiving hemodialysis or immunosuppressive medications. We assessed the association of the mitogen-nil difference with mortality at 6 months, 1 year, and 5 years by Cox regression. Among 16,105 unique individuals, reported mitogen-nil results ranged from \u003C 0.01 to > 10 IU/mL.  \nRelative to values from 0-1, values >10 had HRs (95%) for mortality of 0.33 (0.18-0.63), 0.41 (0.26-0.65), and 0.52 (0.39 -0.70) at 6 months, 1 year, and 5 years respectively after adjustment for age, sex, and test result (indeterminate versus negative) .  \nIncluding frailty, HRs were 0.36 (0.19-0.68), 0.45 (0.29-0.70), and 0.57 (0.42 - 0.77) . With frailty and ADI, HRs were 0.41 (0.20-0.83), 0.50 (0.30-0.84), 0.60 (0.43-0.83). Greater T-cell response to mitogen stimulation in IGRAs is associated with lower hazard of mortality. This common, commercially available lab test may provide additional information to risk-stratify patients.","cbCaiqlQF6LsO8H1","https://ap.wps.com/l/cbCaiqlQF6LsO8H1","pdf",955300,"English","# Background\n# IGRA approach and mitogen-nil difference\n# Study design and covariates\n# Statistical analysis and mortality outcomes\n# Key findings and implications","[{\"question\":\"What immune function measure is evaluated in this study?\",\"answer\":\"The study evaluates interferon-gamma release assays (IGRAs), focusing on the mitogen-nil difference that reflects T-cell function and test validity.\"},{\"question\":\"How was the study sample selected?\",\"answer\":\"All negative and indeterminate IGRA tests were obtained from a large health system, and the sample was limited to the most recent outpatient test results, excluding people receiving hemodialysis or immunosuppressive medications.\"},{\"question\":\"What is the relationship between mitogen-nil values and mortality?\",\"answer\":\"Greater T-cell responses to mitogen stimulation are associated with a lower hazard of all-cause mortality at 6 months, 1 year, and 5 years, with results persisting after adjustments for age, sex, frailty, and area deprivation index.\"}]","INTERFERON-Γ RELEASE ASSAY CONTROL RESULTS ARE ASSOCIATED WITH ALL-CAUSE MORTALITY - Abstract | PDF",1790646229]