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Among 970 respondents, about half expressed interest in on-demand PrEP, linked to infrequent sex and concerns about long-term toxicity.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/interest-in-switching-to-on-demand-hiv-pre-exposure-prophylaxis-prep-among-australian-men-who-have-sex-with-men-using-daily-prep/400665/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/interest-in-switching-to-on-demand-hiv-pre-exposure-prophylaxis-prep-among-australian-men-who-have-sex-with-men-using-daily-prep/400665.png","ImageObject",300,407,{"name":42,"@type":43},"jayni","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-11-01","2026-09-27",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",9,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What was the purpose of the study?","Question",{"text":63,"@type":64},"To measure interest in using on-demand PrEP among Australian users of daily PrEP and to assess the feasibility of a planned on-demand PrEP study.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How was interest in on-demand PrEP assessed?",{"text":68,"@type":64},"A 15-question online survey was emailed to former PrEPX participants, covering demographics, PrEP use, satisfaction with daily PrEP, knowledge of on-demand PrEP, interest, and reasons. Associations were analyzed using univariate and multivariate logistic regression.",{"name":70,"@type":61,"acceptedAnswer":71},"What factors were associated with interest in on-demand PrEP in multivariate analysis?",{"text":72,"@type":64},"Interest was associated with having stopped PrEP, dissatisfaction with daily PrEP, difficulty remembering daily pills, infrequent sex with HIV acquisition risk, concerns about long-term toxicity, and no prior knowledge of on-demand PrEP.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},400665,1790909145,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,110,115,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":108,"slug":109},7,40,"healthcare",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":112,"show_sort_weight":113,"slug":114},8,"Research & Report",30,"research-report",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":116,"show_sort_weight":117,"slug":118},"Religion & Spirituality",20,"religion-spirituality",{"id":117,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":117,"slug":121},"World Cup","world-cup",{"id":123,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":123,"slug":125},10,"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":97,"slug":129},19,"General","general",{"code":4,"msg":82,"data":131},{"doc_id":79,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":107,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":22,"language":139,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":12,"update_tm":143,"read_time":30,"preview_page_count":4},3985747859343,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","P-430  \n# Interest in switching toon-demand HIV pre-exposure prophylaxis (PrEP)among Australian men who have sex with men using daily PrEP.\n\nVincent J Cornelisse 1,2,3,4 , Luxi Lal 1,2 , Brian Price 1,2 , Kathleen E Ryan 1,2,5 , Charlotte Bell 6 ,Louise Owen 7 , Edwina J Wright 1,2,8 , forthe PrEPX study team.  \n1. Monash University*  \n2. The Alfred Hospital*  \n3. Melbourne Sexual Health Centre*  \n4. Kirby Institute, UNSW, Sydney  \n5. Burnet Institute*  \n6. Adelaide Sexual Health Clinic, South Australia  \n7. Statewide Sexual Health Service, Tasmania  \n8. Doherty Institute for Infection and Immunity,The University of Melbourne*  \n* Melbourne, Australia  \n| INTRODUCTION   |\n| --- |\n| The only HIV PrEP regimen approved by theAustralian Therapeutic Goods Administration (TGA) isonce-daily co-formulated tenofovir and emtricitabine(TD*/FTC), however, Australian and someinternational PrEP guidelines recommend that gayand other men who have sex with men (MSM) mayconsider an alternative option of on-demand PrEPdosing. We plan to conduct a study of on-demandPrEP in Australia.   |\n\n\n| AIM   |\n| --- |\n| To measure interest in using on-demand PrEP amongAustralian users of daily PrEP, to assess the feasibilityof our planned study.   |\n\n\n| METHODS   |\n| --- |\n| The PrEPX study was an Australian demonstrationstudy of daily PrEP conducted in Victoria, SouthAustralia and Tasmania, which enrolled over 5 , 000participants between July 2016 and March 2018 ,consisting mainly of MSM. PrEPX ceased on March31 , 2018 .  \u003Cbr>On 23 November 2018 , a single email invitation wassent to all former PrEPX participants to complete anonline survey.  \u003Cbr>The 15-question survey covered demographics,previous and current PrEP use, satisfaction with dailyPrEP use, knowledge of on-demand PrEP, interest instarting on-demand PrEP, and reasons for having ornot having interest in on-demand PrEP. Mostquestions had multiple answer options, andparticipants could select multiple answers. Severalquestions included free-text answer options. Theonline survey remained open for two months.Univariate logistic regression analyses were used toassess associations between interest in on-demandPrEP and other survey questions. Survey questionswith significant (p\u003C0 . 1) associations in univariateanalysis were entered in a multivariate logisticregression model.   |\n\n| CITATION   |\n| --- |\n| In press: Open Forum Infectious Diseases.  \u003Cbr>DOI: 10 . 1093/ofid/ofz287   |\n\n| RESULTS   |\n| --- |\n| 970 complete unique survey responses were received.  \u003Cbr>Median age of respondents was 39 years (IQR 31 to 49) . 966 respondents(100%) were assigned the male sex at birth, and 961 (99%) reported havinga male gender. Almost all respondents (99%, n=965) reported having malesexual partners.  \u003Cbr>Current PrEP use was high (86%, n=830) . Of the 970 participants, 116 (12%)reported not being satisfied with daily PrEP, and reasons for dissatisfactionincluded concerns about toxicity (27%), infrequent need for PrEP due toinfrequent sexual activity (27%), dislike of taking pills (20%), difficultyremembering to take pills (16%), renal problems (5%) and ongoing adverseeffects (4%) . These concerns were expressed more frequently by thosewho were interested in participating inanon-demand PrEP trial.  \u003Cbr>Of the 970 respondents, 469 (48%) reported interest in participating in anon-demand PrEP study forthe following reasons: prospect of less long termtoxicity (n=297, 63%), having sex infrequently (n=282, 60%), moreconvenience compared to daily PrEP (n=245, 52%), lower financial cost(n=225, 48%), and less ongoing adverse effects (n=106, 23%) .Respondents who were not interested in participating in an on-demandPrEP study (n=501) gave the following reasons: concerns abouteffectiveness (n=338, 67%) or feeling anxious (i. e. less protected) (n=189,38%), perceived difficulty remembering to take a dose at least 2 hoursbefore sex (n=292, 58%), having spontaneous or unplanned sex (free textresponses, n=76, 15%), being at low ri","cbCaiibctQvYYfEY","https://ap.wps.com/l/cbCaiibctQvYYfEY","pdf",314502,"English","# Introduction\n# Aim\n# Methods\n# Citation\n# Results\n# Conclusions\n# Ethics\n# Contact details","[{\"question\":\"What was the purpose of the study?\",\"answer\":\"To measure interest in using on-demand PrEP among Australian users of daily PrEP and to assess the feasibility of a planned on-demand PrEP study.\"},{\"question\":\"How was interest in on-demand PrEP assessed?\",\"answer\":\"A 15-question online survey was emailed to former PrEPX participants, covering demographics, PrEP use, satisfaction with daily PrEP, knowledge of on-demand PrEP, interest, and reasons. Associations were analyzed using univariate and multivariate logistic regression.\"},{\"question\":\"What factors were associated with interest in on-demand PrEP in multivariate analysis?\",\"answer\":\"Interest was associated with having stopped PrEP, dissatisfaction with daily PrEP, difficulty remembering daily pills, infrequent sex with HIV acquisition risk, concerns about long-term toxicity, and no prior knowledge of on-demand PrEP.\"}]","Interest in switching to on-demand HIV pre-exposure prophylaxis (PrEP) among Australian men who have sex with men using daily PrEP | PDF",1790513029]