[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-330011-105":59,"doc-detail-330011-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","interconversion-of-cancer-cells-and-induced-pluripotent-stem-cells-review","Interconversion of Cancer Cells and Induced Pluripotent Stem Cells - Review","","Cancer cells, especially cancer stem cells (CSCs), share molecular features with induced pluripotent stem cells (iPSCs), enabling reprogramming of malignant cells into induced pluripotent cancer cells. Conversely, normal iPSCs can be converted into cancer stem-like cells through tumor microenvironment components and genetic manipulation. The resulting CSC models support studies of oncogenic initiation and progression, drug resistance mechanisms, and therapeutic strategy development. This review outlines iPSC-derived CSC model methods, emphasizing exposure-based approaches, including cancer-conditioned media and coculture systems, and assesses genetic, epigenetic, and microenvironment contributions.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/interconversion-of-cancer-cells-and-induced-pluripotent-stem-cells-review/330011/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/interconversion-of-cancer-cells-and-induced-pluripotent-stem-cells-review/330011.png","ImageObject",300,407,{"name":92,"@type":93},"Logic","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":44},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"How can cancer cells be converted into induced pluripotent cancer cells?","Question",{"text":112,"@type":113},"Cancer cells, particularly cancer stem cells, can be reprogrammed using iPSC technologies to generate induced pluripotent cancer cells. This leverages shared molecular features between CSCs and iPSCs.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How can normal iPSCs be turned into cancer stem-like cells?",{"text":117,"@type":113},"Normal iPSCs can be converted into cancer stem-like cells using tumor microenvironment components and genetic manipulation. Exposure-based approaches such as cancer cell-conditioned media or cocultures are highlighted.",{"name":119,"@type":110,"acceptedAnswer":120},"What research purposes do iPSC-derived CSC models serve?",{"text":121,"@type":113},"These models help investigate oncogenic initiation and progression, clarify mechanisms of drug resistance, and support development of therapeutic strategies. They also enable evaluating genetic, epigenetic, and microenvironment factors in CSC behavior.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},330011,1790814025,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":44,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},1099513958762,"https://ap-avatar.wpscdn.com/avatar/1000023916a998db790?x-image-process=image/resize,m_fixed,w_180,h_180&k=1784791008015729253","cells  \nReview  \nInterconversion of Cancer Cells and Induced Pluripotent Stem Cells  \nDrishty B. Sarker 1, Yu Xue 1, Faiza Mahmud 1, Jonathan A. Jocelyn 1 and Qing-Xiang Amy Sang 1,2, *  \nCitation: Sarker, D.B.; Xue, Y.; Mahmud, F.; Jocelyn, J.A.; Sang, Q.-X.A. Interconversion of Cancer Cells and Induced Pluripotent Stem Cells. Cells 2024, 13, 125. [https://](https://)[ ](https://)[doi.org/10.3390/cells13020125](doi.org/10.3390/cells13020125)  \nAcademic Editor: Xuefeng Liu  \nReceived: 19 December 2023  \nRevised: 7 January 2024  \nAccepted: 8 January 2024  \nPublished: 10 January 2024  \nCopyright: © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) .  \n1 Department of Chemistry and Biochemistry, Florida State University, Tallahassee, FL 32306-4390, USA; [ds22@fsu.edu](ds22@fsu.edu) (D.B.S.); [yx21@fsu.edu](yx21@fsu.edu) (Y.X.); [fm23@fsu.edu](fm23@fsu.edu) (F.M.); [jaj21g@fsu.edu](jaj21g@fsu.edu) (J.A.J.)  \n2 Institute of Molecular Biophysics, Florida State University, Tallahassee, FL 32306-4380, USA  \n* Correspondence: [qxsang@chem.fsu.edu](qxsang@chem.fsu.edu); Tel.: +1-850-644-8683; Fax: +1-850-644-8281  \nAbstract: Cancer cells, especially cancer stem cells (CSCs), share many molecular features with induced pluripotent stem cells (iPSCs) that enable the derivation of induced pluripotent cancer cells by reprogramming malignant cells. Conversely, normal iPSCs can be converted into cancer stem-like cells with the help of tumor microenvironment components and genetic manipulation. These CSC models can be utilized in oncogenic initiation and progression studies, understanding drug resistance, and developing novel therapeutic strategies. This review summarizes the role of pluripotency factors in the stemness, tumorigenicity, and therapeutic resistance of cancer cells. Different methods to obtain iPSC-derived CSC models are described with an emphasis on exposure-based approaches. Culture in cancer cell-conditioned media or cocultures with cancer cells can convert normal iPSCs into cancer stem-like cells, aiding the examination of processes of oncogenesis. We further explored the potential of reprogramming cancer cells into cancer-iPSCs for mechanistic studies and cancer dependencies. The contributions of genetic, epigenetic, and tumor microenvironment factors can be evaluated using these models. Overall, integrating iPSC technology into cancer stem cell research holds significant promise for advancing our knowledge of cancer biology and accelerating the development of innovative and tailored therapeutic interventions.  \nKeywords: induced pluripotent stem cells; cancer stem cells; reprogramming; pluripotency; interconversion; cancer stem cell models; induced pluripotent cancer cells  \n1. Introduction  \nInduced pluripotent stem cell (iPSC) technology has been the cornerstone of stem cell research and regenerative medicine since its emergence [1] . The long quest for a more accessible and robust pluripotent cell resource culminated in the breakthrough of pluripotency induction in somatic cells by Yamanaka and Takahashi in 2006 using a combination of four transcription factors—Oct4, Sox2, c-Myc, and Klf4—that are also referred to as“Yamanaka factors” [2] . The demonstration thereby supplanted the need for controversial embryonic stem cell (ESC) sources for generating differentiated human cells of diverse lineages [3,4] . Over the past decade and a half, iPSCs have been extensively utilized in scientific studies due to their enormous scope in cell therapy [5–8] and disease modeling [9,10] for mechanism research and drug discovery.  \nCancer is a generic name for a constellation of malignancies characterized by uncontrolled growth and division [11] . At t","cbCaiiGrL5v1UNjR","https://ap.wps.com/l/cbCaiiGrL5v1UNjR","pdf",1130808,22,"English","# Introduction\n## iPSC technology and pluripotency induction\n## Cancer biology and the need for improved cancer models\n## iPSC-derived approaches to study cancer initiation, progression, and dependencies\n## Cancer stem cell (CSC) models from malignant or pre-malignant cells","[{\"question\":\"How can cancer cells be converted into induced pluripotent cancer cells?\",\"answer\":\"Cancer cells, particularly cancer stem cells, can be reprogrammed using iPSC technologies to generate induced pluripotent cancer cells. This leverages shared molecular features between CSCs and iPSCs.\"},{\"question\":\"How can normal iPSCs be turned into cancer stem-like cells?\",\"answer\":\"Normal iPSCs can be converted into cancer stem-like cells using tumor microenvironment components and genetic manipulation. Exposure-based approaches such as cancer cell-conditioned media or cocultures are highlighted.\"},{\"question\":\"What research purposes do iPSC-derived CSC models serve?\",\"answer\":\"These models help investigate oncogenic initiation and progression, clarify mechanisms of drug resistance, and support development of therapeutic strategies. They also enable evaluating genetic, epigenetic, and microenvironment factors in CSC behavior.\"}]","Interconversion of Cancer Cells and Induced Pluripotent Stem Cells - Review | PDF",1789986534,55]