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The report organizes selected research articles by six key questions, covering diagnostic accuracy, developmental trajectories, genetic and environmental factors, vaccination and exposure studies, and treatment effectiveness through trials and meta-analyses. 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Disorder Research  \nINTERAGENCY AUTISM COORDINATING COMMITTEE  \n2019  \nSUMMARY OF ADVANCES  \nIn Autism Spectrum Disorder Research  \nCOVER DESIGN  \nNIH Medical Arts Branch  \nCOPYRIGHT INFORMATION  \nAll material appearing in this report is in the public domain and may be reproduced or copied.  \nA suggested citation follows.  \nSUGGESTED CITATION  \nInteragency Autism Coordinating Committee (IACC). 2019 IACC Summary of Advances in Autism Spectrum Disorder Research. May 2020. Retrieved from the U.S. Department of Health and Human Services Interagency Autism Coordinating Committee website: [https://iacc.hhs.gov/publications/summary-of-advances/2019/](https://iacc.hhs.gov/publications/summary-of-advances/2019/).  \nii  \nABOUT THE IACC  \nThe Interagency Autism Coordinating Committee (IACC) is a Federal advisory committee charged with coordinating Federal activities concerning autism spectrum disorder (ASD) and providing advice to the Secretary of Health and Human Services (HHS) on issues related to autism. The Committee was established by Congress under the Children's Health Act of 2000, reconstituted under the Combating Autism Act (CAA) of 2006, and renewed most recently under the Autism Collaboration, Accountability, Research, Education, and Support (CARES) Act of 2019.  \nMembership of the Committee includes a wide array of Federal agencies involved in ASD research and services, as well as public stakeholders, including self-advocates, family members of children and adults with ASD, advocates, service providers, and researchers, who represent a variety of perspectives from within the autism community. The IACC membership is composed to ensure that the Committee is equipped to address the wide range of issues and challenges faced by individuals and families affected by autism.  \nUnder the CAA and subsequent reauthorizations, the IACC is required to (1) develop and annually update a strategic plan for ASD research,(2) develop and annually update a summary of advances in ASD research, and (3) monitor Federal activities related to ASD.  \nThrough these and other activities, the IACC provides guidance to HHS and partners with other Federal departments, Federal agencies, research and advocacy organizations, and the broader autism community to accelerate research and enhance services with the goal of profoundly improving the lives of people with ASD and their families.  \n***  \nFor more information about the IACC, see [http://www.iacc.hhs.gov](http://www.iacc.hhs.gov).  \niii  \nTABLE OF CONTENTS  \nINTRODUCTION  ........................................................................ VI  \nARTICLES SELECTED FOR THE 2019 SUMMARY OF ADVANCES  ............................ 1  \nQUESTION 1: HOW CAN I RECOGNIZE THE SIGNS OF ASD, AND WHY IS EARLY DETECTION SO IMPORTANT?  ............................................................3  \nAccuracy of Autism Screening in a Large Pediatric Network  ...................................... 3  \nEvaluation of the Diagnostic Stability of the Early Autism Spectrum Disorder Phenotype in the General Population Starting at 12 Months  .................................................. 5  \nDisparities in Documented Diagnoses of Autism Spectrum Disorder Based on Demographic, Individual, and Service Factors  ............................................7  \nQUESTION 2: WHAT IS THE BIOLOGY UNDERLYING ASD?  .................................8  \nPredictors of Longer-Term Development of Expressive Language in Two Independent Longitudinal Cohorts of Language-Delayed Preschoolers with Autism Spectrum Disorder  .......... 8  \nQUESTION 3: WHAT CAUSES ASD, AND CAN DISABLING ASPECTS OF ASD BE PREVENTED OR PREEMPTED?  ......................................................... 10  \nAssociation of Genetic and Environmental Factors with Autism in a 5-Country Cohort  ............. 10  \nIdentification of Common Genetic Risk Variants for Autism Spectrum","cbCaisIBSRHsH4Rk","https://ap.wps.com/l/cbCaisIBSRHsH4Rk","pdf",1705378,59,"English","# Introduction\n# Articles Selected for the 2019 Summary of Advances\n## Question 1: How can I recognize the signs of ASD, and why is early detection so important?\n## Question 2: What is the biology underlying ASD?\n## Question 3: What causes ASD, and can disabling aspects of ASD be prevented or preempted?\n## Question 4: Which treatments and interventions will help?\n## Question 5: What kinds of services and supports are needed to maximize quality of life for people on the autism spectrum?\n## Question 6: How can we meet the needs of people with ASD as they progress into and through adulthood?","[{\"question\":\"What is the role of the Interagency Autism Coordinating Committee (IACC)?\",\"answer\":\"The IACC is a Federal advisory committee that coordinates Federal activities related to autism spectrum disorder and advises the U.S. Secretary of Health and Human Services on related issues.\"},{\"question\":\"How does the 2019 summary organize the selected research?\",\"answer\":\"It groups selected articles under major questions about early signs, biology, causes, treatments, services for quality of life, and needs during the transition to adulthood.\"},{\"question\":\"Why is early detection emphasized in the report?\",\"answer\":\"The report highlights evidence on autism screening accuracy and developmental evaluation starting early in life, supporting the importance of identifying ASD signs promptly.\"}]","Interagency Autism Coordinating Committee - 2019 Summary of Advances in Autism Spectrum Disorder Research | PDF",1792051465,149]