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Disorder Research  \nINTERAGENCY AUTISM COORDINATING COMMITTEE  \n2014  \nSUMMARY OF ADVANCES  \nin Autism Spectrum Disorder Research  \nCOVER DESIGN  \nNIH Medical Arts Branch  \nCOPYRIGHT INFORMATION  \nAll material appearing in this report is in the public domain and may be reproduced or copied. A suggested citation follows.  \nSUGGESTED CITATION  \nInteragency Autism Coordinating Committee (IACC). 2014 IACC Summary of Advances in Autism Spectrum Disorder Research. April 2016. Retrieved from the U.S. Department of Health and Human Services Interagency Autism Coordinating Committee website: [https://iacc.hhs.gov/publications/summary-of-advances/2014/](https://iacc.hhs.gov/publications/summary-of-advances/2014/).  \nii  \nABOUT THE IACC  \nThe Interagency Autism Coordinating Committee (IACC) is a Federal advisory committee charged with coordinating all activities concerning autism spectrum disorder (ASD) within the U.S. Department of Health and Human Services (HHS) and providing advice to the Secretary of HHS on issues related to autism. It was established by Congress under the Children’s Health Act of 2000, reconstituted under the Combating Autism Act (CAA) of 2006, and renewed under the Combating Autism Reauthorization Act (CARA) of 2011 and the Autism Collaboration, Accountability, Research, Education, and Support (CARES) Act of 2014.  \nMembership of the Committee includes a wide array of Federal agencies involved in ASD research and services, as well as public stakeholders, including self-advocates, family members of children and adults with ASD, advocates, service providers, and researchers, who represent a variety of perspectives from within the autism community. This makeup of the IACC membership is designed to ensure that the Committee is equipped to address the wide range of issues and challenges faced by families and individuals affected by autism.  \nUnder the CAA and subsequent authorizations, the IACC is required to (1) develop and annually update a strategic plan for ASD research,(2) develop and annually update a summary of advances in ASD research, and (3) monitor Federal activities related to ASD.  \nThrough these and other activities, the IACC provides guidance to HHS and partners with the broader autism community to accelerate research and enhance services with the goal of profoundly improving the lives of people with ASD and their families.  \n***  \nFor more information about the IACC, see [http://www.iacc.hhs.gov](http://www.iacc.hhs.gov).  \niii  \nTABLE OF CONTENTS  \nINTRODUCTION  ........................................................................................ vi  \nARTICLES SELECTED FOR THE 2014 SUMMARY OF ADVANCES  ..................................1  \nQUESTION 1: WHEN SHOULD I BE CONCERNED?  ...................................................2  \nApproaches to enhancing the early detection of autism spectrum disorders: a systematic review of the literature  ............................................................................................ 2  \nValidation of the Modified Checklist for Autism in Toddlers, Revised with Follow-Up (M-CHAT-R/F)  ...... 4  \nQUESTION 2: HOW CAN I UNDERSTAND WHAT IS HAPPENING?  ..................................5  \nSynaptic, transcriptional and chromatin genes disrupted in autism  ....................................... 5  \nBehavioral and cognitive characteristics of females and males with autism in the Simons Simplex Collection  ................................................................................................... 7  \nA higher mutational burden in females supports a‘‘female protective model’’ in neurodevelopmental disorders  ................................................................................................... 8  \nGastrointestinal symptoms in autism spectrum disorder: a meta-analysis  ................................ 9  \nConvergence of genes and cellular pathwa","cbCaiqYZUayXLUTk","https://ap.wps.com/l/cbCaiqYZUayXLUTk","pdf",5001089,54,"English","# Introduction\n# Articles Selected for the 2014 Summary of Advances\n## Question 1: When Should I Be Concerned?\n## Question 2: How Can I Understand What Is Happening?\n## Question 3: What Caused This to Happen and Can It Be Prevented?\n## Question 4: Which Treatments and Interventions Will Help?\n## Question 5: Where Can I Turn for Services?\n## Question 6: What Does the Future Hold, Particularly for Adults?\n## Question 7: What Other Infrastructure and Surveillance Needs Must Be Met?","[{\"question\":\"What is the Interagency Autism Coordinating Committee (IACC) required to do under the authorizations referenced in the report?\",\"answer\":\"Under the CAA and subsequent authorizations, the IACC must develop and annually update a strategic plan for ASD research, develop and annually update a summary of advances in ASD research, and monitor federal activities related to ASD.\"},{\"question\":\"How does the 2014 summary structure its research content?\",\"answer\":\"The summary organizes selected advances around seven core questions, covering early detection and concern, mechanisms, causes and prevention, treatments and interventions, services, future needs (including adults), and infrastructure and surveillance requirements.\"},{\"question\":\"What kinds of topics are included for understanding ASD mechanisms and characteristics?\",\"answer\":\"The included articles cover topics such as disrupted synaptic/transcriptional/chromatin genes, behavioral and cognitive characteristics across females and males, and models supporting sex-specific protective effects in neurodevelopmental disorders.\"}]","Interagency Autism Coordinating Committee - 2014 Summary of Advances in Autism Spectrum Disorder Research | PDF",1792051105,136]