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Over recent decades, research has clarified how gut microbial communities influence cancer biology and responses to treatment. This review summarizes evidence on cancer pathogenesis and outlines current guidance for clinicians on modifying the microbiome in patients receiving chemotherapy or immunotherapy, emphasizing checkpoint inhibitors and five cancer groups.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/interaction-of-the-gut-microbiome-with-cancer-treatment/332497/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/interaction-of-the-gut-microbiome-with-cancer-treatment/332497.png","ImageObject",300,407,{"name":92,"@type":93},"Miles","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":52},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"How does the gut microbiome influence health and well-being beyond digestion?","Question",{"text":112,"@type":113},"It affects metabolism, mood, and cognitive function through the activities of symbiotic microorganisms living in the gut.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What does the review cover regarding cancer and cancer treatment?",{"text":117,"@type":113},"It summarizes how the gut microbiome relates to cancer pathogenesis and reviews current guidelines for modifying the microbiome in patients receiving chemotherapy or immunotherapy.",{"name":119,"@type":110,"acceptedAnswer":120},"Why is the link between microbial species and therapies considered unclear?",{"text":121,"@type":113},"The review states that the relationship between microbial species and therapies to cure malignancies is largely unclear, and that it delineates relationships studied so far and conclusions drawn.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},332497,1790114905,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":52,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":44,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144},13056703019404,"https://ap-avatar.wpscdn.com/davatar_29158cc5080c5b710cf443261637dec0","Interaction of the Gut Microbiome With Cancer Treatment  \nPAULA M. BARRENECHEA, MPAS, PA-C  \nThis article is distributed under the terms of the Creative Commons Attr ibution Non-Commercial Non-Derivative License, which permits unrestricted non- -commercial and non derivative use, distribution, and reproduction in any medium, provided the original work is properly c ited .  \nFrom The University of Texas MD Anderson Cancer Center, Houston, Texas  \nAuthor’s disclosure of conflicts of interest are found at the end of this article.  \nCorrespondence to: Paula M. Barrenechea, MPAS, PA-C, 1515 Holcombe Boulevard, Houston, TX 77030  \nE-mail: [pmbarrenechea@mdanderson.org](pmbarrenechea@mdanderson.org)  \n[https://doi.org/10.6004/jadpro.2024.15.5.3](https://doi.org/10.6004/jadpro.2024.15.5.3)[ ](https://doi.org/10.6004/jadpro.2024.15.5.3)© 2024 BroadcastMed LLC  \nJ Adv Pract Oncol 2024;15(5):311–319  \nAbstract  \nThe gut microbiome is known to influence health and well-being beyond the gastrointestinal system, including metabolism, mood, and cognitive function. Research on the influence of the gut microbiome on cancer and cancer treatment has expanded in recent decades. This review discusses the effects of the gut microbiome on the pathogenesis of certain cancers, as well as the current guidelines and recommendations for health-care professionals for modifying the gut microbiome in cancer patients currently receiving chemotherapy or immunotherapy. The focus of this review is on five major areas of gut microbiome research (colorectal cancer, melanoma, renal cell carcinoma and non–small cell lung cancer, lymphoma, and acute leukemia) in which therapies, and particularly checkpoint inhibitors, have considerably improved survival outcomes. The relationship between microbial species and therapies to cure malignancies is largely unclear. This review will delineate the relationships being studied and conclusions to draw from the research in these areas thus far.  \nThe gut microbiome con  \ntains millions of microor  \nganisms that live in a sym  \nbiotic manner with their hosts, which are humans. Without these microorganisms, the gut does not operate at its intended capacity. The gut microbiome is an emerging area of medical interest not limited to the gut, because the microbiome plays an important role in metabolism, mood, and cognitive function (Aarnoutse et al., 2019) . The relationship of the gut microbiome to health and well-being has widened our view and led to initiatives to better understand the gut microbiome.  \nWithin the past decade, research has expanded to understanding the gut microbiome’s composition in the context of its impact on cancer treatment. This review will discuss the gut microbiome’s effect on cancer pathogenesis, cancers in which the gut microbiome is currently studied, modifications of the gut microbiome in preparation for and while receiving cancer treatment, and current guidelines and recommendations for modifying the gut microbiome in cancer patients receiving surgery for tumor removals, chemotherapy, or immunotherapies such as a checkpoint inhibitors.  \nGUT MICROBIOME AND CANCER PATHOGENESIS  \nThe human gut microbiome holds tens of trillions of microorganisms that contribute to the functioning of metabolism and immunity of each person (Ursell et al., 2012). It is vastly diverse, and this diversity is key to optimizing gut function and regulating mood. Although certain groups of microbes in the gut microbiome in colorectal cancer are linked to an increased risk of developing inflammatory, autoimmune, and malignant diseases, these effects are not limited to the gastrointestinal system (Suraya et al., 2000). For example, dysbiosis, which is an imbalance of the gut microbial community, is related to the development of breast cancers, lung cancers, and adult T-cell leukemias (Suraya et al., 2000).  \nIn a review of the gut microbiome, Suraya and colleagues (2000) noted that the ability ofthe microbiome to create dysregulat","cbCaihzZd6XjwkkU","https://ap.wps.com/l/cbCaihzZd6XjwkkU","pdf",1043345,"English","# Abstract\n# Gut Microbiome and Cancer Pathogenesis\n# Gut Microbiome Research in Cancers\n## Colorectal Cancer","[{\"question\":\"How does the gut microbiome influence health and well-being beyond digestion?\",\"answer\":\"It affects metabolism, mood, and cognitive function through the activities of symbiotic microorganisms living in the gut.\"},{\"question\":\"What does the review cover regarding cancer and cancer treatment?\",\"answer\":\"It summarizes how the gut microbiome relates to cancer pathogenesis and reviews current guidelines for modifying the microbiome in patients receiving chemotherapy or immunotherapy.\"},{\"question\":\"Why is the link between microbial species and therapies considered unclear?\",\"answer\":\"The review states that the relationship between microbial species and therapies to cure malignancies is largely unclear, and that it delineates relationships studied so far and conclusions drawn.\"}]","Interaction of the Gut Microbiome With Cancer Treatment | PDF",1789998483,23]