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Dysregulation of ITGB1 has been linked over the past two decades to cancer development and progression as well as multiple benign diseases, suggesting prognostic and therapeutic potential. This review compiles current knowledge of ITGB1 roles in disease and therapy, and outlines future research directions and application prospects.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/integrin-1-in-disorders-and-cancers-molecular-mechanisms-and-therapeutic-targets/331808/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/integrin-1-in-disorders-and-cancers-molecular-mechanisms-and-therapeutic-targets/331808.png","ImageObject",300,407,{"name":92,"@type":93},"Logic","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":44},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is Integrinβ-1 (ITGB1) and why is it important?","Question",{"text":112,"@type":113},"Integrinβ-1 (ITGB1) is a crucial transmembrane glycoprotein signaling receptor in the integrin family. 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Cell Communication and Signaling (2024) 22:71  \n[https://doi.org/10.1186/s12964-023-01338-3](https://doi.org/10.1186/s12964-023-01338-3)  \nCell Communication and Signaling  \n REVIEW Open Access  \nIntegrinβ-1  \nin disorders and cancers:  \nmolecular mechanisms and therapeutic targets  \nChen Su1,2†, Jie Mo1,2†, Shuilin Dong1,2†, Zhibin Liao1,2*, Bixiang Zhang1,2,3,4,5* and Peng Zhu1,2,3,4,5*  \nAbstract  \nIntegrinβ-1 (ITGB1) is a crucial member of the transmembrane glycoprotein signaling receptor family and is also central to the integrin family. It forms heterodimers with other ligands, participates in intracellular signaling and controls a variety of cellular processes, such as angiogenesis and the growth of neurons; because of its role in bidirectional signaling regulation both inside and outside the membrane, ITGB1 must interact with a multitude of substances, so a variety of interfering factors can affect ITGB1 and lead to changes in its function. Over the past 20 years, many studies have confirmed a clear causal relationship between ITGB1 dysregulation and cancer development and progression in a wide range of benign diseases and solid tumor types, which may imply that ITGB1 is a prognostic biomarker and a therapeutic target for cancer treatment that warrants further investigation. This review summarizes the biological roles of ITGB1 in benign diseases and cancers, and compiles the current status of ITGB1 function and therapy in various aspects of tumorigenesis and progression. Finally, future research directions and application prospects of ITGB1 are suggested.  \nKeywords Integrinβ-1, Drug target, Cancer metastasis  \n†Chen Su, Jie Mo and Shuilin Dong contributed equally to this work.  \n*Correspondence:  \nZhibin Liao [zhibliao@hust.edu.cn](zhibliao@hust.edu.cn)[ ](zhibliao@hust.edu.cn)Bixiang Zhang [bixiangzhang@hust.edu.cn](bixiangzhang@hust.edu.cn)[ ](bixiangzhang@hust.edu.cn)Peng Zhu [zhupeng@tjh.tjmu.edu.cn](zhupeng@tjh.tjmu.edu.cn)  \n1 Hepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue, Wuhan 430030, Hubei, People’s Republic of China  \n2 Hubei Key Laboratory of Hepato-Pancreato-Biliary Diseases, Wuhan, Hubei, People’s Republic of China  \n3 Key Laboratory of Organ Transplantation, Ministry of Education, Wuhan, Hubei, People’s Republic of China  \n4 Key Laboratory of Organ Transplantation, National Health Commission, Wuhan, Hubei, People’s Republic of China  \n5 Key Laboratory of Organ Transplantation, Chinese Academy of Medical Sciences, Wuhan, Hubei, People’s Republic of China  \nBackground  \nSince their discovery in the 1980s, integrins have been developed into cell adhesion transmembrane receptors that act as extracellular matrix (ECM)-cytoskeletal linkers and transmit biochemical and mechanical signals between cells and their environment in a variety of physiological and pathological conditions [1–3]. Transmembrane glycoprotein receptors known as integrin proteins are ubiquitous heterodimers that serve largely as signaling proteins in mammals [4]. The amino acid (aa) sequences of integrins are evolutionarily conserved and the structure of the various variants can be divided into three parts (a large extracellular domain, a short transmembrane domain, and a short cytoplasmic domain). The extracellular domain of these variants participates in ligand binding. There are 18 and 8 different variations of the α and β-subunits that comprise each integrin, respectively, and they combine to produce 24 known heterodimers. Integrin proteins can be categorized into several families based on the different receptors that can be  \n© The Author(s) 2024. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Cr","cbCaif8tyjWWBySF","https://ap.wps.com/l/cbCaif8tyjWWBySF","pdf",5463679,24,"English","# Background\n## Integrins as signaling and adhesion receptors\n## Integrin families and ligand recognition\n# ITGB1 overview\n## Genomic location and structure","[{\"question\":\"What is Integrinβ-1 (ITGB1) and why is it important?\",\"answer\":\"Integrinβ-1 (ITGB1) is a crucial transmembrane glycoprotein signaling receptor in the integrin family. It participates in intracellular signaling and controls cellular processes such as angiogenesis and neuronal growth.\"},{\"question\":\"How does ITGB1 dysregulation relate to diseases?\",\"answer\":\"Research described in the review supports a causal relationship between ITGB1 dysregulation and cancer development and progression. It is also associated with changes in function across a range of benign diseases.\"},{\"question\":\"What does the review aim to cover about ITGB1?\",\"answer\":\"The review summarizes biological roles of ITGB1 in benign diseases and cancers. It also compiles the current status of ITGB1 function and therapy and suggests future research directions and application prospects.\"}]","Integrinβ-1 in disorders and cancers - molecular mechanisms and therapeutic targets | PDF",1789995260]