[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-356363-105":3,"doc-detail-356363-en":81,"detail-sidebar-cat-0-en-105":99},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","integrative-oncology-for-biochemical-recurrence-of-epithelial-ovarian-cancer","Integrative Oncology for Biochemical Recurrence of Epithelial Ovarian Cancer","","Biochemical recurrence of epithelial ovarian cancer (EOC), marked by rising CA-125 without clinical or radiologic evidence, creates a frequent and difficult management situation in which cytotoxic therapy does not improve survival and can reduce quality of life. This review evaluates integrative oncology (IO) interventions aimed at supporting women during this vulnerable period. Mind-body approaches reduce anxiety, distress, and fear of recurrence, while exercise and acupuncture improve vitality, mood, and sleep.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/integrative-oncology-for-biochemical-recurrence-of-epithelial-ovarian-cancer/356363/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/integrative-oncology-for-biochemical-recurrence-of-epithelial-ovarian-cancer/356363.png","ImageObject",300,407,{"name":42,"@type":43},"Liam","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-23","2026-09-23",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",9,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"How is biochemical recurrence of epithelial ovarian cancer defined?","Question",{"text":63,"@type":64},"It is defined as rising CA-125 levels (and sometimes other tumor markers) in the absence of clinical or radiologic evidence of disease.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"Why is this stage considered challenging for patients?",{"text":68,"@type":64},"Women often experience significant anxiety, uncertainty, and reduced quality of life even before systemic therapy is initiated.",{"name":70,"@type":61,"acceptedAnswer":71},"Which integrative oncology interventions are highlighted as potentially beneficial?",{"text":72,"@type":64},"Mind-body therapies (mindfulness, yoga, cognitive behavioral therapy), exercise, acupuncture, anti-inflammatory nutritional strategies (including vitamin D sufficiency and omega-3 intake), and certain natural compounds and repurposed drugs such as metformin.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},356363,1790207661,{"code":4,"msg":82,"data":83},"success",{"doc_id":79,"user_id":84,"nickname":42,"user_avatar":85,"doc_module":4,"category_id":86,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":87,"file_id":88,"file_url":89,"file_type":90,"file_size":91,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":92,"language":93,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":94,"faqs":95,"seo_title":96,"seo_description":12,"update_tm":97,"read_time":98},8796095461564,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d",7,"Current Oncology Reports (2026) 28:14  \n[https://doi.org/10.1007/s1](https://doi.org/10.1007/s1) 1912-026-01762-x  \nREVIEW  \nIntegrative Oncology for Biochemical Recurrence of Epithelial Ovarian Cancer  \nTara Berman1,2 · Emad Matanes3 · Chen Ben David3 · Moshe Frenkel4,5  \nReceived: 22 September 2025 / Accepted: 26 January 2026 © The Author(s) 2026  \nAbstract  \nPurpose of Review Biochemical recurrence of epithelial ovarian cancer (EOC), defined as rising CA-125 levels without clinical or radiologic evidence of disease, is a frequent and challenging scenario. Cytotoxic therapy initiated at this stage does not improve survival and may diminish quality of life. This review evaluates integrative oncology (IO) interventions that may support women during this vulnerable period.  \nRecent Findings Mind–body therapies, including mindfulness, yoga, and cognitive behavioral therapy, have demonstrated benefits in reducing anxiety, distress, and fear of recurrence. Exercise and acupuncture improve vitality, mood, and sleep. Nutritional strategies—particularly anti-inflammatory diets, vitamin D sufficiency, and omega-3 fatty acid intake—promote resilience and overall health. Natural compounds such as green tea, medicinal mushrooms, modified citrus pectin, melatonin, and AHCC show immune-modulating or anti-tumor effects in preclinical or early clinical studies. Among repurposed nononcologic drugs, metformin provides the strongest rationale, especially for women with type 2 diabetes.  \nSummary Although ovarian cancer–specific trials are limited, IO approaches are safe, feasible, and evidence-informed. They address psychosocial distress, improve quality of life, and may influence disease biology, offering meaningful options for women under surveillance during biochemical recurrence.  \nKeywords Biochemical relapse, epithelial ovarian cancer, complementary medicine · Integrative oncology · Cancer care · Patient centered care · Supportive care  \nIntroduction  \nBiochemical relapse of epithelial ovarian cancer (EOC)—defined as rising levels of cancer antigen-125 (CA-125) or other tumor markers in the absence of clinical or  \n􀀍 Moshe Frenkel [frenkelm@netvision.net.il](frenkelm@netvision.net.il)  \n1 Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston 02115, MA, USA  \n2 Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA  \n3 Gynecologic Oncology Unit, Department of Obstetrics & Gynecology, Rambam Health Care Campus, Haifa, Israel  \n4 Integrative Oncology Service, Oncology Division, Rambam Health Care Campus, Hashoftim 1 B, Zichron Yaacov, Haifa 30900, Israel  \n5 Department of Family Medicine, The University of Texas Medical Branch at Galveston, Galveston, TX, USA  \nradiological evidence of disease—presents a unique clinical challenge. Women in this stage often face significant anxiety, uncertainty, and reduced quality of life (QoL), even before systemic therapy is initiated. Integrative oncology (IO) offers a holistic, patient-centered approach that may help address these unmet needs.  \nThe standard initial treatment for EOC consists of cytoreductive surgery followed by platinum-based chemotherapy. While about 70% of patients with advanced disease respond to first-line therapy and achieve complete remission, most will experience recurrence within 18 to 28 months [1] . Recurrence is also observed in approximately 25% of women with early-stage disease (Stage I–II) and in as many as 80% of those with advanced-stage disease (Stage III–IV) [2] . A large proportion of these relapses are first detected by tumor marker elevation alone: in follow-up studies, more than half of women in remission after advanced EOC showed asymptomatic CA-125 elevation as the earliest sign of recurrence [3] . For example, one study reported that 46% of relapses initially presented as “biochemical-only” recurrence [4] .  \n1 3  \nDefining Biochemical Relapse  \nBiochemical relapse in EOC refers to recurrence detected by rising tumor markers, most commonly CA-125","cbCaiotiAXiChYiM","https://ap.wps.com/l/cbCaiotiAXiChYiM","pdf",834505,8,"English","# Abstract\n# Purpose of Review\n# Recent Findings\n# Summary\n# Keywords\n# Introduction\n## Defining Biochemical Relapse\n## Biochemical Relapse: to Treat or Not to Treat?","[{\"question\":\"How is biochemical recurrence of epithelial ovarian cancer defined?\",\"answer\":\"It is defined as rising CA-125 levels (and sometimes other tumor markers) in the absence of clinical or radiologic evidence of disease.\"},{\"question\":\"Why is this stage considered challenging for patients?\",\"answer\":\"Women often experience significant anxiety, uncertainty, and reduced quality of life even before systemic therapy is initiated.\"},{\"question\":\"Which integrative oncology interventions are highlighted as potentially beneficial?\",\"answer\":\"Mind-body therapies (mindfulness, yoga, cognitive behavioral therapy), exercise, acupuncture, anti-inflammatory nutritional strategies (including vitamin D sufficiency and omega-3 intake), and certain natural compounds and repurposed drugs such as metformin.\"}]","Integrative Oncology for Biochemical Recurrence of Epithelial Ovarian Cancer | PDF",1790125018,20,{"code":4,"msg":82,"data":100},[101,105,109,113,118,123,126,130,133,136,140],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":102,"show_sort_weight":103,"slug":104},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":106,"show_sort_weight":107,"slug":108},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":110,"show_sort_weight":111,"slug":112},"Exam",70,"exam",{"id":114,"doc_module":4,"doc_module_name":25,"category_name":115,"show_sort_weight":116,"slug":117},5,"Comic",60,"comic",{"id":119,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":121,"slug":122},6,"Technology",50,"technology",{"id":86,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":124,"slug":125},40,"healthcare",{"id":92,"doc_module":4,"doc_module_name":25,"category_name":127,"show_sort_weight":128,"slug":129},"Research & Report",30,"research-report",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":131,"show_sort_weight":98,"slug":132},"Religion & Spirituality","religion-spirituality",{"id":98,"doc_module":4,"doc_module_name":25,"category_name":134,"show_sort_weight":98,"slug":135},"World Cup","world-cup",{"id":137,"doc_module":4,"doc_module_name":25,"category_name":138,"show_sort_weight":137,"slug":139},10,"Lifestyle","lifestyle",{"id":141,"doc_module":4,"doc_module_name":25,"category_name":142,"show_sort_weight":114,"slug":143},19,"General","general"]