[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-330325-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-330325-en":130},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","integrative-analysis-revealed-a-correlation-of-pias-family-genes-expression-with-prognosis-immunomodulation-and-chemotherapy","Integrative analysis revealed a correlation of PIAS family genes expression with prognosis, immunomodulation and chemotherapy","","Protein inhibitor of activated STATs (PIAS) family genes show pleiotropic roles, yet their pan-cancer expression links to prognosis, immune infiltration, tumor microenvironment, immunotherapy, and chemotherapy remain insufficiently characterized. Multi-omics analyses assessed PIAS members across cancers using univariate Cox and Kaplan–Meier models, and related expression to microenvironment features, immune subtypes, stemness scores, and drug sensitivity. Functional validation in HCC used wound healing and transwell assays.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/research-report/","Research & Report",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/integrative-analysis-revealed-a-correlation-of-pias-family-genes-expression-with-prognosis-immunomodulation-and-chemotherapy/330325/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/integrative-analysis-revealed-a-correlation-of-pias-family-genes-expression-with-prognosis-immunomodulation-and-chemotherapy/330325.png","ImageObject",300,407,{"name":42,"@type":43},"Lucas Martin","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-11-03","2026-09-21",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",6,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What biological effects do PIAS family genes have, and why are they studied?","Question",{"text":63,"@type":64},"PIAS genes regulate protein post-translational modification, transcriptional coregulation, and gene editing, and they may relate to immune infiltration and tumor progression.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How was PIAS gene expression analyzed across cancers in this study?",{"text":68,"@type":64},"The study used multi-omics data across pan-cancer, evaluating prognostic value by univariate Cox regression and Kaplan–Meier, and assessing correlations with microenvironment and immune-related metrics.",{"name":70,"@type":61,"acceptedAnswer":71},"What did the results show about PIAS genes and prognosis or therapy response?",{"text":72,"@type":64},"PIAS expression was heterogeneous across tumors and linked to poor prognosis in multiple cancers, associated with disease-free survival across pan-cancer, and predicted responses to chemotherapy and immunotherapy.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},330325,1790733881,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,105,110,114,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":102,"show_sort_weight":103,"slug":104},"Technology",50,"technology",{"id":106,"doc_module":4,"doc_module_name":25,"category_name":107,"show_sort_weight":108,"slug":109},7,"Healthcare",40,"healthcare",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":112,"slug":113},8,30,"research-report",{"id":115,"doc_module":4,"doc_module_name":25,"category_name":116,"show_sort_weight":117,"slug":118},9,"Religion & Spirituality",20,"religion-spirituality",{"id":117,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":117,"slug":121},"World Cup","world-cup",{"id":123,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":123,"slug":125},10,"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":97,"slug":129},19,"General","general",{"code":4,"msg":82,"data":131},{"doc_id":79,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":111,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":139,"language":140,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":12,"update_tm":144,"read_time":145,"preview_page_count":4},8796095360427,"https://ap-avatar.wpscdn.com/davatar_994ba38a5ba835b3df7d355c54d3ed8d","Zhang et al. European Journal  \nEuropean Journal of Medical Research (2024) 29:195  \n[https://doi.org/10.1186/s40001-024-01795-7](https://doi.org/10.1186/s40001-024-01795-7 of Medical Research)[ of Medical Research](https://doi.org/10.1186/s40001-024-01795-7 of Medical Research)  \n RESEARCH Open Access  \nIntegrative analysis revealed a correlation  \nof PIAS family genes expression with prognosis, immunomodulation and chemotherapy  \nQiqi Zhang1†, Junkui Zhang2†, Tianyi Lan1, Jiayue He1, Bin Lei1, Hongnan Wang3, Zhiqiang Mei 1* and Chaoxiang Lv 1*  \nAbstract  \nBackground Protein inhibitor of activated STATs (PIAS) has pleiotropic biological effects, such as protein post-translational modification, transcriptional coregulation and gene editing. It is reported that PIAS family genes are also correlated with immune cells infiltration in cancers that highlights their unnoticed biological role in tumor progression. However, the relationship of their expression with prognosis, immune cell infiltration, tumor microenvironment, and immunotherapy in pan-cancer has been rarely reported.  \nMethods The multi-omics data were used to investigate the expression level of PIAS family members in pancancer, and the prognostic value of their expression in different tumors was analyzed by univariate Cox regression and Kaplan–Meier. Correlation analysis was used to investigate the relationship of PIAS gene expression with tumor microenvironment, immune infiltrating subtypes, stemness score and drug sensitivity. In addition, we also used wound healing and transwell assays to verify the biological effects of PIAS family gene expression on invasion and metastasis of HCC cells.  \nResults We found that PIAS family genes expression is significantly heterogeneous in tumors by multi-genomic analysis, and associated with poor prognosis in patients with multiple types of cancer. Furthermore, we also found that genetic alterations of PIAS family genes were not only common in different types of human tumors, but were also significantly associated with disease-free survival (DFS) across pan-cancer. Single-cell analysis revealed that PIAS family genes were mainly distributed in monocytes/macrophages. Additionally, we also found that their expression was associated with tumor microenvironment (including stromal cells and immune cells) and stemness score (DNAss and RNAss) . Drug sensitivity analysis showed that PIAS family genes were able to predict the response to chemotherapy and immunotherapy. PIAS family genes expression is closely related to tumor metastasis, especially PIAS3 . High PIAS3 expression significantly promotes the migration and invasion of liver cancer cell lines (HCC-LM3 and MHCC97-H) .  \nConclusions Taking together, these findings contribute to determine whether the PIAS family genes are a potential oncogenic target gene, which have important contribution for the development of cancer immunotherapy.  \n†Qiqi Zhang and Junkui Zhang have contributed equally to this work.  \n*Correspondence: Zhiqiang Mei [xuguangyin1@163.com](xuguangyin1@163.com)[ ](xuguangyin1@163.com)Chaoxiang Lv [lvchaoxiang@126.com](lvchaoxiang@126.com)  \nFull list of author information is available at the end of the article  \n© The Author(s) 2024. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from t","cbCaivddoewUwWAo","https://ap.wps.com/l/cbCaivddoewUwWAo","pdf",11517369,21,"English","# Abstract\n## Background\n## Methods\n## Results\n## Conclusions\n# Introduction","[{\"question\":\"What biological effects do PIAS family genes have, and why are they studied?\",\"answer\":\"PIAS genes regulate protein post-translational modification, transcriptional coregulation, and gene editing, and they may relate to immune infiltration and tumor progression.\"},{\"question\":\"How was PIAS gene expression analyzed across cancers in this study?\",\"answer\":\"The study used multi-omics data across pan-cancer, evaluating prognostic value by univariate Cox regression and Kaplan–Meier, and assessing correlations with microenvironment and immune-related metrics.\"},{\"question\":\"What did the results show about PIAS genes and prognosis or therapy response?\",\"answer\":\"PIAS expression was heterogeneous across tumors and linked to poor prognosis in multiple cancers, associated with disease-free survival across pan-cancer, and predicted responses to chemotherapy and immunotherapy.\"}]","Integrative analysis revealed a correlation of PIAS family genes expression with prognosis, immunomodulation and chemotherapy | PDF",1789988169,53]