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This study evaluates how collagen-related genes relate to prostate cancer prognosis by building a collagen-gene risk scoring model from TCGA expression data, integrating it with clinical factors in a prognostic nomogram, and validating key gene functions with cellular assays and PLOD3 immunohistochemistry.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/research-report/","Research & Report",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/integrative-analysis-regarding-the-correlation-between-collagen-related-genes-and-prostate-cancer/333670/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/integrative-analysis-regarding-the-correlation-between-collagen-related-genes-and-prostate-cancer/333670.png","ImageObject",300,407,{"name":42,"@type":43},"Oliver","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-11-06","2026-09-21",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",7,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What was the study’s main purpose regarding collagen-related genes?","Question",{"text":63,"@type":64},"To examine the relationship between collagen-associated genes and prostate cancer prognosis, aiming to identify possible associations and relevant therapeutic targets.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How were collagen-related genes and the risk score model constructed?",{"text":68,"@type":64},"Gene expression data from TCGA were used to identify collagen-related genes and develop a risk score model linked to biochemical recurrence-free survival (BRFS).",{"name":70,"@type":61,"acceptedAnswer":71},"Which findings support the clinical or biological relevance of the key genes?",{"text":72,"@type":64},"Four collagen-associated genes (PLOD3, COL1A1, MMP11, FMOD) were identified as significant; low-risk groups had improved survival, and PLOD3 suppression reduced proliferation, invasion, migration, and colony formation while showing differential expression in tissues.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},333670,1790872389,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,110,114,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":107,"show_sort_weight":108,"slug":109},"Healthcare",40,"healthcare",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":112,"slug":113},8,30,"research-report",{"id":115,"doc_module":4,"doc_module_name":25,"category_name":116,"show_sort_weight":117,"slug":118},9,"Religion & Spirituality",20,"religion-spirituality",{"id":117,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":117,"slug":121},"World Cup","world-cup",{"id":123,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":123,"slug":125},10,"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":97,"slug":129},19,"General","general",{"code":4,"msg":82,"data":131},{"doc_id":79,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":111,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":139,"language":140,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":12,"update_tm":144,"read_time":112,"preview_page_count":4},8796095461610,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","Xiao et al. BMC Cancer (2024) 24:1038 BMC Cancer  \n[https://doi.org/10.1186/s12885-024-12783-9](https://doi.org/10.1186/s12885-024-12783-9)  \nRESEARCH Open Access  \nIntegrative analysis regarding the correlation between collagen-related genes and prostate cancer  \nYunfei Xiao 1,2†, Cong Lai 1,2†, Jintao Hu 1,2†, Yelisudan Mulati 1,2, Xiaoting Xu 1,2, Jiawen Luo 1,2, Degeng Kong 1,2, Cheng Liu 1,3* and Kewei Xu 1,3,4*  \nAbstract  \nPurpose Prostate cancer (PCa) is a common malignancy in men, with an escalating mortality rate attributed to Recurrence and metastasis. Recent studies have illuminated collagen’s critical regulatory role within the tumor microenvironment, significantly influencing tumor progression. Accordingly, this investigation is dedicated to examining the relationship between genes linked to collagen and the prognosis of PCa, with the objective of uncovering any possible associations between them.  \nMethods Gene expression data for individuals with prostate cancer were obtained from theTCGA repository. Collagen-related genes were identified, leading to the development of a risk score model associated with biochemical recurrence-free survival (BRFS) . A prognostic nomogram integrating the risk score with essential clinical factors was crafted and evaluated for efficacy. The influence of key collagen-related genes on cellular behavior was confirmed through various assays, including CCK8, invasion, migration, cell cloning, and wound healing. Immunohistochemical detection was used to evaluate PLOD3 expression in prostate cancer tissue samples.  \nResults Our study identified four key collagen-associated genes (PLOD3, COL1A1, MMP11, FMOD) as significant. Survival analysis revealed that low-risk groups, based on the risk scoring model, had significantly improved prognoses. The risk score was strongly associated with prostate cancer prognosis. Researchers then created a nomogram, which demonstrated robust predictive efficacy and substantial clinical applicability. Remarkably, the suppression of PLOD3 expression notably impeded the proliferation, invasion, migration, and colony formation capabilities of PCa cells. Conclusion The risk score, derived from four collagen-associated genes, could potentially act as a precise prognostic indicator for BRFS of patients. Simultaneously, our research has identified potential therapeutic targets related to collagen. Notably, PLOD3 was differential ly expressed in cancer and para-cancer tissues in clinical specimens and it also was validated through in vitro studies and shown to suppress PCa tumorigenesis following its silencing.  \n†Yunfei Xiao, Cong Lai and Jintao Hu contributed equally to this work.  \n*Correspondence:  \nCheng Liu [liuch278@mail.sysu.edu.cn](liuch278@mail.sysu.edu.cn)[ ](liuch278@mail.sysu.edu.cn)Kewei Xu [xukewei@mail.sysu.edu.cn](xukewei@mail.sysu.edu.cn)  \nFull list of author information is available at the end of the article  \n© The Author(s) 2024. Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit [http://](http://)[ ](http://)[creativecommons.org/l](creative","cbCaiahcvZDW8L0y","https://ap.wps.com/l/cbCaiahcvZDW8L0y","pdf",6181765,12,"English","# Abstract\n# Introduction\n## Prostate cancer burden and treatment challenges\n## Collagen, ECM, and immune microenvironment effects\n# Methods\n# Results\n# Conclusion","[{\"question\":\"What was the study’s main purpose regarding collagen-related genes?\",\"answer\":\"To examine the relationship between collagen-associated genes and prostate cancer prognosis, aiming to identify possible associations and relevant therapeutic targets.\"},{\"question\":\"How were collagen-related genes and the risk score model constructed?\",\"answer\":\"Gene expression data from TCGA were used to identify collagen-related genes and develop a risk score model linked to biochemical recurrence-free survival (BRFS).\"},{\"question\":\"Which findings support the clinical or biological relevance of the key genes?\",\"answer\":\"Four collagen-associated genes (PLOD3, COL1A1, MMP11, FMOD) were identified as significant; low-risk groups had improved survival, and PLOD3 suppression reduced proliferation, invasion, migration, and colony formation while showing differential expression in tissues.\"}]","Integrative analysis regarding the correlation between collagen-related genes and prostate cancer | PDF",1790003554]