[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-456574-105":59,"doc-detail-456574-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","integrating-secretagogues-into-clinical-dry-eye-care-insights-from-asian-clinical-experience","Integrating secretagogues into clinical dry eye care - Insights from Asian clinical experience","","Dry eye is a multifactorial condition defined by tear film instability that causes visual disturbances and discomfort. In Asia, clinical management often emphasizes tear-film restoration, especially by using secretagogues such as diquafosol and rebamipide to enhance aqueous and mucin secretion. This review summarizes clinical rationale and real-world use across outpatient care, cataract perioperative management, and contact-lens–associated ocular surface disorders. A tear film–oriented diagnostic framework helps classify subtypes and guide treatment selection, with clinical trial and observational evidence supporting safety, tear stability improvements, epithelial protection, and higher patient satisfaction.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/integrating-secretagogues-into-clinical-dry-eye-care-insights-from-asian-clinical-experience/456574/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/integrating-secretagogues-into-clinical-dry-eye-care-insights-from-asian-clinical-experience/456574.png","ImageObject",300,407,{"name":92,"@type":93},"mieayamfan","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-30",true,{"@type":102,"interactionType":103,"userInteractionCount":44},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is the main clinical concept behind secretagogue therapy for dry eye in Asia?","Question",{"text":112,"@type":113},"Asian management often uses a tear film–oriented strategy that restores specific tear components. Secretagogues like diquafosol and rebamipide promote aqueous and/or mucin secretion to improve tear film function.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Which settings does the review cover for integrating secretagogues into care?",{"text":117,"@type":113},"It addresses general outpatient management, perioperative treatment around cataract surgery, and ocular surface disorders associated with contact lens use.",{"name":119,"@type":110,"acceptedAnswer":120},"How does the tear film–oriented diagnostic framework support treatment selection?",{"text":121,"@type":113},"The framework classifies dry eye subtypes using tear breakup patterns and identifies deficiencies in aqueous, lipid, or mucin components. This helps match therapies to the underlying tear deficiency.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},456574,1790844817,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":44,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":44,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144,"preview_page_count":4},962090893677,"https://ap-avatar.wpscdn.com/davatar_3d24733baf745e90a7e4bdd5f77d97b2","| Access this article online |\n| --- |\n| Quick Response Code: |\n| |\n| Website:\u003Cbr>[http://journals.lww.com/TJOP](http://journals.lww.com/TJOP) |\n| DOI:\u003Cbr>10.4103/tjo.TJO-D-25-00110 |\n\nDepartment of Innovative Visual Science, Osaka University Graduate School of Medicine, Osaka, Japan  \n*Address for correspondence:  \nDr. Shizuka Koh, Department of Innovative Visual Science, The University of Osaka Graduate School of Medicine, Room E7,  \n2-2 Yamadaoka, Suita, Osaka 565-0871, Japan. E-mail: cizciz@  \n[gmail.com](gmail.com)  \nSubmission: 05-07-2025  \nAccepted: 25-08-2025  \nPublished: 11-11-2025  \nReview Article-Narrative Review  \nTaiwan J Ophthalmol 2025;15:526‑534  \nIntegrating secretagogues into clinical dry eye care: Insights from Asian clinical experience  \nShizuka Koh*  \nAbstract:  \nDry eye is a multifactorial condition characterized by tear film instability, leading to visual disturbancesand discomfort. In Asia, clinical management often follows a tear film–oriented approach that emphasizes restoring specific tear components, particularly through the use of secretagogues such as diquafosol and rebamipide. These agents promote aqueous and/or mucin secretion and have been widely adopted in Japan and other Asian countries as frontline therapies for various tear film deficiencies. This review outlines the clinical rationale for secretagogue use and summarizes real‑world applications across different settings, including general outpatient care, perioperative management for cataract surgery, and contact lens‑related ocular surface disorders. Tear Film–Oriented Diagnosis–a framework for classifying dry eye subtypes based on tear breakup patterns and identifying deficiencies in aqueous, lipid, or mucin components – is presented as a practical guide for treatment selection. Evidence from clinical trials and long‑term observational studies supports the safety and efficacy of diquafosol and rebamipide in improving tear stability, reducing epithelial damage, and enhancing patient satisfaction. By highlighting regional practice patterns and accumulated clinical experience, this article offers perspectives on effectively integrating secretagogues into dry eye management. These insights may contribute to a broader understanding of individualized, mechanism‑based treatment strategies beyond inflammation suppression.  \nKeywords:  \nAsia, diquafosol, dry eye, rebamipide, secretagogues  \nIntroduction  \nDry eye is a  \nmarked by  \nmultifactorial condition an unstable tear film and  \na wide range of ocular symptoms. [1,2] Inflammation, epithelial damage, and neurosensory abnormalities are recognized as contributors to the condition, reflecting its complex pathophysiology. The goal of treatment is to relieve symptoms, restore tear film homeostasis, and improve patients’visual and functional quality of life.  \nTreatment approaches vary significantly between regions. In the United States and other Western countries, the therapeutic focus is often on anti‑inflammatory agents  \nThis is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercialNoDerivatives 4.0 License (CC BY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.  \nFor reprints [contact:](contact: WKHLRPMedknow_reprints@wolterskluwer.com)[ WKHLRPMedknow_reprints@wolterskluwer.com](contact: WKHLRPMedknow_reprints@wolterskluwer.com)  \nand treatments targeting tear evaporation.[3,4] In contrast, many Asian countries have adopted a tear film‑oriented strategy [3] that emphasizes restoration of specific tear components, especially using secretagogues, which stimulate the secretion of aqueous and mucin components of the tear film.[4] Among these, diquafosol and rebamipide are two key therapeutic agents widely used in Asia. Although viscosity agents, such as sodium hyaluronate, are also commonly prescribed, this review ","cbCaislKb2jJs8jp","https://ap.wps.com/l/cbCaislKb2jJs8jp","pdf",3795609,"English","# Abstract\n# Introduction\n# Regional Perspectives on Dry Eye Management\n# Treatment Approaches and Clinical Use of Secretagogues\n## Tear Film–Oriented Diagnosis Framework\n## Evidence Base: Trials and Long-term Observational Studies\n# Practical Integration into Dry Eye Management","[{\"question\":\"What is the main clinical concept behind secretagogue therapy for dry eye in Asia?\",\"answer\":\"Asian management often uses a tear film–oriented strategy that restores specific tear components. Secretagogues like diquafosol and rebamipide promote aqueous and/or mucin secretion to improve tear film function.\"},{\"question\":\"Which settings does the review cover for integrating secretagogues into care?\",\"answer\":\"It addresses general outpatient management, perioperative treatment around cataract surgery, and ocular surface disorders associated with contact lens use.\"},{\"question\":\"How does the tear film–oriented diagnostic framework support treatment selection?\",\"answer\":\"The framework classifies dry eye subtypes using tear breakup patterns and identifies deficiencies in aqueous, lipid, or mucin components. This helps match therapies to the underlying tear deficiency.\"}]","Integrating secretagogues into clinical dry eye care - Insights from Asian clinical experience | PDF",1790746416,23]