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Mammary gland tumors in intact female dogs represent the most prevalent neoplasms, with surgery remaining the primary treatment. Histopathological evaluation is essential to confirm diagnosis and guide therapy selection. This research analyzes clinicopathological, immunohistochemical, and cytogenetic features of canine mammary tumors, highlighting shared characteristics with human breast cancer and supporting dogs as a relevant animal model.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/integrated-study-of-canine-mammary-tumors-histopathology-immunohistochemistry-and-cytogenetic-findings/332516/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/integrated-study-of-canine-mammary-tumors-histopathology-immunohistochemistry-and-cytogenetic-findings/332516.png","ImageObject",300,407,{"name":92,"@type":93},"Miles","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-23","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":34},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What was the objective of the study on canine mammary tumors?","Question",{"text":112,"@type":113},"The study investigated clinicopathological, immunohistochemical, and cytogenetic features of canine mammary tumors to support their relevance to human breast cancer research.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Why are histopathological examinations emphasized in canine mammary tumor evaluation?",{"text":117,"@type":113},"Histopathology confirms diagnosis and helps decide the best therapy, making it fundamental to treatment planning.",{"name":119,"@type":110,"acceptedAnswer":120},"What cytogenetic pattern was observed across the cases?",{"text":121,"@type":113},"Cytogenetic analysis showed high chromosomal instability with significant aneuploidy in all cases, and polyploidy was detected in 62.5%.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},332516,1790428911,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":34,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},13056703019404,"https://ap-avatar.wpscdn.com/davatar_29158cc5080c5b710cf443261637dec0","veterinary sciences  \nArticle  \nIntegrated Study of Canine Mammary Tumors Histopathology, Immunohistochemistry, and Cytogenetic Findings  \nTiago Ferreira 1,2,3,4, *, Maria Miranda 1, Rosário Pinto-Leite 5,6, João F. Mano 4, Rui Medeiros 3,7,8,9,10, Paula A. Oliveira 1,2, *,† and Adelina Gama 11,12,†  \nCitation: Ferreira, T.; Miranda, M.; Pinto-Leite, R.; Mano, J.F.; Medeiros, R.; Oliveira, P.A.; Gama, A. Integrated Study of Canine Mammary Tumors Histopathology, Immunohistochemistry, and Cytogenetic Findings. Vet. Sci. 2024, 11, 409. [https://doi.org/](https://doi.org/)[ ](https://doi.org/)[10.3390/vetsci11090409](10.3390/vetsci11090409)  \nAcademic Editor: Sang-Ki Kim  \nReceived: 17 July 2024  \nRevised: 29 August 2024  \nAccepted: 3 September 2024  \nPublished: 4 September 2024  \nCopyright: © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) .  \n1 Centre for the Research and Technology of Agro-Environmental and Biological Sciences (CITAB), University of Trás-os-Montes and Alto Douro (UTAD), 5000-801 Vila Real, Portugal; [al64075@alunos.utad.pt](al64075@alunos.utad.pt)  \n[2](2 Institute for Innovation)[ Institute for Innovation](2 Institute for Innovation), [Capacity Building and Sustainability of Agri-Food Production](Capacity Building and Sustainability of Agri-Food Production) ([Inov4Agro](Inov4Agro)), UTAD, 5000-801 Vila Real, Portugal  \n3 Molecular Oncology and Viral Pathology Group, Research Center of IPO Porto (CI-IPOP)/ RISE@CI-IPOP (Health Research Network), Portuguese Oncology Institute of Porto (IPO Porto),  \nPorto Comprehensive Cancer Center (Porto.CCC), 4200-072 Porto, Portugal; [ruimedei@ipoporto.min-saude.pt](ruimedei@ipoporto.min-saude.pt)  \n4 Department of Chemistry, CICECO—Aveiro Institute of Materials, University of Aveiro, Campus Universitário de Santiago, 3810-193 Aveiro, Portugal; [jmano@ua.pt](jmano@ua.pt)  \n5 Laboratory of Genetics and Andrology, Hospital Center of Trás-os-Montes and Alto Douro, E.P.E., 5000-508 Vila Real, Portugal; [mlleite@chtmad.min-saude.pt](mlleite@chtmad.min-saude.pt)  \n6 Experimental Pathology and Therapeutics Group, IPO Porto Research Center, Portuguese Institute of Oncology of Porto Francisco Gentil, E.P.E., 4200-072 Porto, Portugal  \n7 Faculty of Medicine, University of Porto (FMUP), 4200-319 Porto, Portugal  \n8 ICBAS—Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, 4050-313 Porto, Portugal  \n9 Molecular Oncology and Viral Pathology Group, Faculty of Health Sciences, Fernando Pessoa University, 4249-004 Porto, Portugal  \n10 Research Department, Portuguese League Against Cancer (NRNorte), 4200-172 Porto, Portugal  \n11 Animal and Veterinary Research Centre (CECAV), University of Trás-os-Montes and Alto Douro (UTAD), 5000-801 Vila Real, Portugal; [agama@utad.pt](agama@utad.pt)  \n12 Associate Laboratory for Animal and Veterinary Sciences (AL4AnimalS), University of Trás-os-Montes and Alto Douro (UTAD), 5000-801 Vila Real, Portugal  \n* Correspondence: [al58092@alunos.utad.pt](al58092@alunos.utad.pt) (T.F.); [pamo@utad.pt](pamo@utad.pt) (P.A.O.)† These authors contributed equally to this work.  \nSimple Summary: Canine mammary tumors are the most common tumor in intact female dogs. This study aimed to investigate the clinicopathological, immunohistochemical, and cytogenetic features of canine mammary tumors. This study is relevant due to the fact that canine and human breast cancer share similar epidemiological and histopathological characteristics, reinforcing the potential for dogs to serve as an effective animal model for human breast cancer research.  \nAbstract: Cancer is a complex pathological condition associated with substantial rates of mortality and morbidity in both hum","cbCaiavu165iIjqf","https://ap.wps.com/l/cbCaiavu165iIjqf","pdf",2047863,15,"English","# Introduction\n## Study summary\n# Abstract\n## Keywords","[{\"question\":\"What was the objective of the study on canine mammary tumors?\",\"answer\":\"The study investigated clinicopathological, immunohistochemical, and cytogenetic features of canine mammary tumors to support their relevance to human breast cancer research.\"},{\"question\":\"Why are histopathological examinations emphasized in canine mammary tumor evaluation?\",\"answer\":\"Histopathology confirms diagnosis and helps decide the best therapy, making it fundamental to treatment planning.\"},{\"question\":\"What cytogenetic pattern was observed across the cases?\",\"answer\":\"Cytogenetic analysis showed high chromosomal instability with significant aneuploidy in all cases, and polyploidy was detected in 62.5%.\"}]","Integrated Study of Canine Mammary Tumors Histopathology, Immunohistochemistry, and Cytogenetic Findings | PDF",1789998567,38]