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This review examines how glucose dysregulation links to multiple dermatological conditions and evaluates integrative management approaches. A comprehensive literature search across PubMed, Google Scholar, and Embase identified peer-reviewed studies on glucose dysregulation in dermatology. Results show associations between elevated insulin and inflammatory markers with psoriasis, acne, acanthosis nigricans, seborrheic dermatitis, and hidradenitis suppurativa. Findings suggest diet and probiotics may help modulate inflammation and metabolic health.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/insulin-resistance-metabolic-syndrome-and-inflammatory-skin-disease-integrative-review/461658/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/insulin-resistance-metabolic-syndrome-and-inflammatory-skin-disease-integrative-review/461658.png","ImageObject",300,407,{"name":92,"@type":93},"LangkahRina","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-30",true,{"@type":102,"interactionType":103,"userInteractionCount":44},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"How are insulin resistance and metabolic syndrome connected to skin disease in the review?","Question",{"text":112,"@type":113},"The review describes glucose dysregulation and metabolic syndrome as contributing factors to several dermatological conditions, with associations supported by elevated insulin-related and inflammatory markers.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Which skin conditions are highlighted as being significantly associated with metabolic dysregulation?",{"text":117,"@type":113},"The review identifies significant associations with psoriasis, acne, acanthosis nigricans, seborrheic dermatitis, and hidradenitis suppurativa.",{"name":119,"@type":110,"acceptedAnswer":120},"What integrative management approaches does the review emphasize?",{"text":121,"@type":113},"The review emphasizes holistic approaches that address glucose control and incorporates lifestyle modifications, with dietary interventions and probiotics discussed as potential tools for modulating inflammation and improving metabolic health.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},461658,1790960710,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":44,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":41,"preview_page_count":4},962090893776,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","Review  \nInsulin Resistance, Metabolic Syndrome, and Inflammatory Skin Disease  \nKrisha Tripathy 1,*, Ajay S. Dulai 2,3, Mildred Min 2,3,4 and Raja K. Sivamani 2,3,4,5,6  \nAcademic Editor: Stamatis Gregoriou  \nReceived: 11 November 2025  \nRevised: 19 December 2025  \nAccepted: 29 December 2025  \nPublished: 1 January 2026  \nCopyright: © 2026 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license.  \n1 Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10027, USA  \n2 Integrative Skin Science and Research, Sacramento, CA 95815, USA  \n3 Integrative Research Institute, Sacramento, CA 95819, USA  \n4 College of Medicine, California Northstate University, Elk Grove, CA 95757, USA  \n5 Pacific Skin Institute, Sacramento, CA 95815, USA  \n6 Department of Dermatology, University of California-Davis, Sacramento, CA 95816, USA  \n* Correspondence: [kt2967@cumc.columbia.edu](kt2967@cumc.columbia.edu)  \nAbstract  \nBackground/Objectives: The skin is an important indicator of overall health, and its relationship with insulin resistance (IR) and metabolic syndrome (MetS) has garnered increasing attention. This review explores the connection between glucose dysregulation and various dermatological conditions, aiming to highlight integrative approaches for management. Methods: A comprehensive literature search was conducted in June and July 2024 across PubMed, Google Scholar, and Embase. Peer-reviewed studies on glucose dysregulation in dermatology were identified using terms such as “insulin,” “metabolic syndrome,” and “dermatological manifestations.” Relevant studies were selected based on their contributions to understanding these relationships. Results: The review identified significant associations between glucose dysregulation, MetS, and conditions such as psoriasis, acne, acanthosis nigricans, seborrheic dermatitis, and hidradenitis suppurativa. Key findings indicated that elevated insulin levels and inflammatory markers correlate with the severity of these skin disorders. Notably, dietary interventions and probiotics show potential in modulating inflammation and improving metabolic health. Conclusions: There is a clear link between glucose dysregulation and several dermatological conditions, underscoring the importance of a holistic treatment approach. By addressing glucose control and incorporating lifestyle modifications, clinicians can improve patient outcomes and mitigate the complications associated with IR and MetS. Further research is essential to refine these integrative strategies and assess their effectiveness in clinical practice.  \nKeywords: glucose control; insulin resistance; metabolic syndrome; diabetes; psoriasis; acne; hidradenitis suppurativa; acanthosis nigricans; seborrheic dermatitis  \n1. Introduction  \nAs the body’s primary barrier, skin is highly susceptible to environmental changes. Beyond this, the skin can also reflect internal and systemic health. Metabolic syndrome (MetS), which is a condition that encompasses factors including abdominal obesity, IR, dyslipidemia, and high blood pressure [1], has been posited to significantly contribute to the development of various dermatoses. A systematic review evaluated the association between MetS and common skin disorders with thirty-seven studies involving 13,830 participants [2] . They found a higher prevalence of MetS in patients with psoriasis (PsO), hidradenitis suppurativa (HS), vitiligo, androgenetic alopecia, and lichen  \nplanus LP. Additionally, individuals with seborrheic dermatitis and rosacea demonstrated increased IR, high blood pressure, and elevated blood lipids. Meta-analysis revealed a significant link between MetS and skin diseases (pooled odds ratio [OR]: 3.28, 95% confidence interval: 2.62–4.10) [2] . These findings highlight the need for comprehensive management by dermatologists and multidisciplinary ","cbCaihEhyDnwOeIH","https://ap.wps.com/l/cbCaihEhyDnwOeIH","pdf",247526,12,"English","# Abstract\n# Introduction\n## Metabolic syndrome and skin disorders\n# Results\n## Links to insulin resistance and metabolic syndrome (Table 1)\n# Methods\n## Literature search strategy and selection\n# Conclusions","[{\"question\":\"How are insulin resistance and metabolic syndrome connected to skin disease in the review?\",\"answer\":\"The review describes glucose dysregulation and metabolic syndrome as contributing factors to several dermatological conditions, with associations supported by elevated insulin-related and inflammatory markers.\"},{\"question\":\"Which skin conditions are highlighted as being significantly associated with metabolic dysregulation?\",\"answer\":\"The review identifies significant associations with psoriasis, acne, acanthosis nigricans, seborrheic dermatitis, and hidradenitis suppurativa.\"},{\"question\":\"What integrative management approaches does the review emphasize?\",\"answer\":\"The review emphasizes holistic approaches that address glucose control and incorporates lifestyle modifications, with dietary interventions and probiotics discussed as potential tools for modulating inflammation and improving metabolic health.\"}]","Insulin Resistance, Metabolic Syndrome, and Inflammatory Skin Disease - Integrative Review | PDF",1790762070]