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Respiratory muscle weakness commonly reduces vital capacity, cough effectiveness, and increases risk of atelectasis and pulmonary infections. Inspiratory muscle training (IMT) is established in other conditions, but its use in GBS is unknown. Objective: assess safety, feasibility, and preliminary effectiveness of the InspireGBs IMT protocol.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/inspiregbs-inspiratory-muscle-training-in-people-with-guillain-barre-syndrome-a-feasibility-study/318760/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/inspiregbs-inspiratory-muscle-training-in-people-with-guillain-barre-syndrome-a-feasibility-study/318760.png","ImageObject",300,407,{"name":92,"@type":93},"Noah","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-22","2026-09-20",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",22,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What problem does InspireGBs address in people with Guillain-Barré syndrome?","Question",{"text":113,"@type":114},"Respiratory muscle weakness is common in GBS and can reduce vital capacity and cough strength, contributing to atelectasis and pulmonary infections. InspireGBs applies inspiratory muscle training to improve inspiratory muscle function.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"How was the InspireGBs protocol delivered in the feasibility study?",{"text":118,"@type":114},"It was a pre/post feasibility study. Sessions were conducted twice daily, 5 times per week, with three sets of 10 breaths per session over 6 weeks.",{"name":120,"@type":111,"acceptedAnswer":121},"What did the study find about safety and feasibility?",{"text":122,"@type":114},"Recruitment and retention were high, adherence reached 96%, and no adverse effects or safety issues were reported. Sessions lasted about 4 to 6 minutes.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},318760,1790931222,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":39,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":46},8796095462418,"https://ap-avatar.wpscdn.com/avatar/80000253c1241d02b47?x-image-process=image/resize,m_fixed,w_180,h_180&k=1778826106357471780","Received: 12 September 2023 Revised: 20 May 2024 Accepted: 13 June 2024  \nDOI: 10.1002/pmrj.13251  \nORI G INAL A R TI CLE  \nInspireGBs – Inspiratory muscle training in people with Guillain-Barré syndrome: A feasibility study  \nMiguel P. Almeida PT, MSc 1,2  | Jo˜ao Carlos Winck MD, PhD 3  | Alda Marques PT, PhD 2   \n1North Rehabilitation Centre, Local Health Unit Gaia e Espinho, Vila Nova de Gaia, Portugal  \n2Lab3R – Respiratory Research and Rehabilitation Laboratory, School of Health Sciences and Institute of Biomedicine (iBiMED), University of Aveiro, Aveiro, Portugal  \n3Faculty of Medicine, University of Porto, Porto, Portugal  \nCorrespondence  \nMiguel P. Almeida, Centro de Reabilitaç˜ao do Norte, Avenida Infante Sagres 22, Valadares, 4405-565 Vila Nova de Gaia, Portugal. [Email:](Email: miguelalmeida.ft@gmail.com)[ miguelalmeida.ft@gmail.com](Email: miguelalmeida.ft@gmail.com)  \nFunding information  \nFundaç˜ao para a Ciência e a Tecnologia, Grant/Award Number: PhD grant 2022 .12265. BDANA  \nAbstract  \nBackground: Guillain-Barré syndrome (GBS) is a rare immune-mediated peripheral nerve disease often preceded by infections. Respiratory muscle weakness is a common complication in this population, leading to decreased vital capacity, weakened coughing ability, atelectasis, and pulmonary infections. Inspiratory muscle training (IMT) has been widely used to enhance inspiratory muscle strength and pulmonary function in various diseases; however, its application in GBS is unknown. Objective: To assess the safety, feasibility, and preliminary effectiveness of an IMT protocol—InspireGBs—in people with GBS.  \nMethods: A pre/post feasibility study was conducted. Feasibility was determined by participant recruitment/retention, adherence, time spent in each session, and adverse events. Secondary outcome was inspiratory muscle strength. InspireGBs consisted of twice daily sessions 5 times/week, three sets of 10 breaths in each session, for 6 weeks. Initial resistance was set at 50% of participant’s baseline maximal inspiratory pressure (MIP) and with a weekly increase of 10% calculated from the previous week’s training intensity, if tolerated, otherwise the increase was 5% .  \nResults: Eleven patients (63% male; 63 ± 9 years) were recruited from inpatient rehabilitation and 10 completed the study. Recruitment and retention rates were high (79% and 91%, respectively) . Excellent adherence rate (96%) was obtained with no reported adverse effects or safety issues. Sessions lasted from 4 to 6 minutes. The MIP improved (pretraining: 39 [26 .5–50] cm H2O vs. posttraining: 61 [56 .3–64.5] cm H2O, p = .005 and pretraining: 38 [30 .5–53.8]% of predicted vs. posttraining: 60 [54 .28–71.58]% of predicted, p = .009) with the InspireGBs. Conclusion: InspireGBs is safe, feasible, and may be effective in improving inspiratory muscle strength in individuals with GBS. A randomized controlled trial is now needed to strengthen these findings.  \nINTRODUCTION  \nGuillain-Barré syndrome (GBS) is a rare inflammatory demyelinating polyradiculoneuropathy, typically preceded by infection or immune stimulation, which triggers an abnormal autoimmune response targeting peripheral nerves and spinal roots.1 GBS is a frequent cause of acute flaccid paralysis, marked by rapid progressive muscle weakness, diminished deep tendon reflexes or areflexia, usually in a symmetrical and ascending pattern that develops over days to weeks.2 Electrodiagnostic studies have the capacity to distinguish among the three electrophysiological subtypes of  \nclassical GBS: acute inflammatory demyelinating polyradiculoneuropathy, acute motor axonal neuropathy, and acute motor sensory axonal neuropathy.1  \nOverall, the clinical course, severity, and outcomes of people with GBS are highly heterogeneous.2 Nevertheless, significant disability is often observed and includes incomplete recovery of motor (ie, ambulation) and sensory function, fatigue, pain, respiratory insufficiency, and psychologic","cbCaimpk7WjaSFml","https://ap.wps.com/l/cbCaimpk7WjaSFml","pdf",444953,"English","# Abstract\n## Background\n## Objective\n## Methods\n## Results\n## Conclusion\n# Introduction","[{\"question\":\"What problem does InspireGBs address in people with Guillain-Barré syndrome?\",\"answer\":\"Respiratory muscle weakness is common in GBS and can reduce vital capacity and cough strength, contributing to atelectasis and pulmonary infections. InspireGBs applies inspiratory muscle training to improve inspiratory muscle function.\"},{\"question\":\"How was the InspireGBs protocol delivered in the feasibility study?\",\"answer\":\"It was a pre/post feasibility study. Sessions were conducted twice daily, 5 times per week, with three sets of 10 breaths per session over 6 weeks.\"},{\"question\":\"What did the study find about safety and feasibility?\",\"answer\":\"Recruitment and retention were high, adherence reached 96%, and no adverse effects or safety issues were reported. Sessions lasted about 4 to 6 minutes.\"}]","InspireGBs - Inspiratory muscle training in people with Guillain-Barré syndrome: A feasibility study | PDF",1789941159]