[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-364316-105":59,"doc-detail-364316-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","insights-on-bmi-1-therapeutic-targeting-in-head-and-neck-cancers","Insights on Bmi-1 therapeutic targeting in head and neck cancers","","B lymphoma Mo-MLV insertion region 1 homolog (Bmi-1) is a polycomb-complex protein central to epigenetic transcriptional silencing and key to stem-cell homeostasis and tumorigenesis. Although many studies clarify its transcriptional control, post-translational modifications, and roles in bioenergetics, pathologies, and DNA damage response, its full therapeutic promise remains unmet. This review synthesizes current Bmi-1 knowledge, emphasizing oral cancer progression and clinical strategy development for head and neck cancer.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/insights-on-bmi-1-therapeutic-targeting-in-head-and-neck-cancers/364316/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/insights-on-bmi-1-therapeutic-targeting-in-head-and-neck-cancers/364316.png","ImageObject",300,407,{"name":92,"@type":93},"Finn","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-01","2026-09-23",true,{"@type":102,"interactionType":103,"userInteractionCount":39},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Why is Bmi-1 considered important in head and neck cancers?","Question",{"text":112,"@type":113},"Bmi-1 is linked to stemness and oncogenesis. In cancer stem cell biology, Bmi-1+ cells contribute to chemoresistance and metastasis, making Bmi-1 a promising therapeutic target.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What is the role of Bmi-1 in cancer-related epigenetic regulation?",{"text":117,"@type":113},"Bmi-1 mediates epigenetic transcriptional silencing through chromatin structure within the polycomb complex.",{"name":119,"@type":110,"acceptedAnswer":120},"How can targeting Bmi-1 influence therapy outcomes?",{"text":121,"@type":113},"Inhibiting Bmi-1 rescinds cancer stem cell functions and re-sensitizes cancer cells to chemotherapy. Developing therapeutic approaches targeting Bmi-1 may advance clinical treatment strategies for head and neck cancer.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},364316,1790623182,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":39,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":34,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144},34359740700684,"https://ap-avatar.wpscdn.com/avatar/1f400023980c374ae676?_k=1777273430885731487","ONCOLOGY RESEARCH 2025 33(2): 301-307 REVIEW  \nInsights on Bmi-1 therapeutic targeting in head and neck cancers  \nJESSIE REYES-CARMONA*  \nLICIFO, Department of Restorative Sciences, Faculty of Dentistry, University of Costa Rica (HNSCC), San José, 11501, Costa Rica  \nKeywords: Cancer stem cell (CSC), B lymphoma Mo-MLV insertion region 1 homolog Bmi-1, Therapeutic resistance, Head and neck squamous cell carcinoma (HNSCC), Targeted therapy  \nAbstract: The B lymphoma Mo-MLV insertion region 1 homolog (Bmi-1) protein of the polycomb complex is an essential mediator of the epigenetic transcriptional silencing by the chromatin structure. It has been reported to be crucial for homeostasis of the stem cells and tumorigenesis. Though years of investigation have clarified Bmi-1’s transcriptional regulation, post-translational modifications, and functions in controlling cellular bioenergetics, pathologies, and DNA damage response, the full potential of this protein with so many diverse roles are still unfulfilled. Bmi-1 is overexpressed in many human malignancies. Unraveling the Bmi-1’s precise functional role in head and neck cancers can be attractive for mechanisms-based developmental therapeutics. This review attempts to synthesize the current knowledge on Bmi-1 with an emphasis on the role that Bmi-1 plays in oral cancer progression and evaluates how this can be used in advancing clinical treatment strategies for head and neck cancer. Bmi-1 is a promising target for therapy because it has been linked to a stemness and oncogenesis signature. However, to use Bmi-1 as a prognostic marker and a therapeutic target in the long run, new methods are imperative for further characterization of the physiological roles of Bmi-1 . Current biological insights of Bmi-1 as a master regulator of stem cell self-renewal have emerged as a prominent player in cancer stem cell (CSC) biology. Bmi-1+ cells mediatechemoresistance and metastasis. On the other hand, inhibiting Bmi-1 rescinds CSC function and re-sensitizes cancer cells to chemotherapy. Therefore, elucidating therapeutic approaches targeting Bmi-1 can be leveraged to further  \nresearch analysis to advance clinical treatment strategies for head and neck cancer.  \nIntroduction  \nTumors that arise in the salivary glands, nose, pharynx, mouth cavity, and other parts of the head and neck region are commonly referred to as head and neck cancers. About 400,000 deaths and more than 900,000 new diagnoses of head and neck squamous cell carcinoma (HNSCC) are reported each year, making it the sixth most prevalent cancer type in terms of incidence [1] . The Third National Cancer Survey found a five-year cause-specific survival rate of 56% for patients with HNSCC, with variations based on sex and race [2] . According to current trends, approximately 40,000 new cases of HNSCC are expected to be diagnosed in the US every year [3,4] . To improve patient outcomes and develop targeted therapies, comprehending the molecular mechanisms underlying the development and progression of HNSCC is imperative.  \n*Address correspondence to: Jessie Reyes-Carmona, [jessie.reyes@ucr.ac.cr](jessie.reyes@ucr.ac.cr)  \nReceived: 09 May 2024; Accepted: 29 July 2024;  \nPublished: 16 January 2025  \nSince cancer stem cells (CSCs) are involved in all of these extremely aggressive cancers, treatment resistance is triggered, which frequently results in relapse [5] . Bmi-1, a protein that is a member of the polycomb group, has been regarded as a promising target for therapeutic intervention. This protein is essential for several cellular processes, including cell cycle regulation, differentiation, senescence, and renewal [6] . This review focuses on Bmi-1’s involvement in head and neck cancer, a condition for which it is assumed to be a promising target for implementing innovative therapeutic interventions.  \nBiomarkers in Head and Neck Cancer  \nSeveral biomarkers, both molecular and clinical, are important in the diagnosis, prognosis, and manag","cbCaivyUXGiZQk3b","https://ap.wps.com/l/cbCaivyUXGiZQk3b","pdf",2353596,"English","# Introduction\n# Biomarkers in Head and Neck Cancer\n# Bmi-1 Protein","[{\"question\":\"Why is Bmi-1 considered important in head and neck cancers?\",\"answer\":\"Bmi-1 is linked to stemness and oncogenesis. In cancer stem cell biology, Bmi-1+ cells contribute to chemoresistance and metastasis, making Bmi-1 a promising therapeutic target.\"},{\"question\":\"What is the role of Bmi-1 in cancer-related epigenetic regulation?\",\"answer\":\"Bmi-1 mediates epigenetic transcriptional silencing through chromatin structure within the polycomb complex.\"},{\"question\":\"How can targeting Bmi-1 influence therapy outcomes?\",\"answer\":\"Inhibiting Bmi-1 rescinds cancer stem cell functions and re-sensitizes cancer cells to chemotherapy. Developing therapeutic approaches targeting Bmi-1 may advance clinical treatment strategies for head and neck cancer.\"}]","Insights on Bmi-1 therapeutic targeting in head and neck cancers | PDF",1790156923,18]