[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-386101-105":59,"doc-detail-386101-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","insights-into-the-new-molecular-updates-in-acute-myeloid-leukemia-pathogenesis","Insights into the New Molecular Updates in Acute Myeloid Leukemia Pathogenesis","","As biological understanding of acute myeloid leukemia advances, classification systems evolve to reflect newly clarified mechanisms. Early approaches relied on blast morphology, but genomic technologies have driven rapid refinements in how these cancers are organized. Two recent frameworks—the International Consensus Classification and the 5th edition WHO classification—were introduced to incorporate modern genomic findings, and this review summarizes key updates and the biological insights behind them.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/insights-into-the-new-molecular-updates-in-acute-myeloid-leukemia-pathogenesis/386101/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/insights-into-the-new-molecular-updates-in-acute-myeloid-leukemia-pathogenesis/386101.png","ImageObject",300,407,{"name":92,"@type":93},"Riley West","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-23","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":29},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Why have acute myeloid leukemia classification systems changed in recent years?","Question",{"text":112,"@type":113},"The review explains that advances in genomic technologies increased knowledge of disease biology, prompting refinement of classification systems beyond morphology.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Which two new classification systems are emphasized?",{"text":117,"@type":113},"The article highlights the International Consensus Classification (ICC) and the 5th edition of the World Health Organization (WHO5) classification.",{"name":119,"@type":110,"acceptedAnswer":120},"What is the role of RUNX1 in the updated AML framework?",{"text":121,"@type":113},"RUNX1 encodes a transcription factor essential for hematopoietic differentiation, and the review discusses how new classification entities handle RUNX1-related alterations, including changes to blast threshold discussions for RUNX1 mutation cases.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},386101,1791129891,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":29,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":36},1099523885074,"https://ap-avatar.wpscdn.com/davatar_9964176cb1d06d4a9deccf72a44ae3dc","Review  \nInsights into the New Molecular Updates in Acute Myeloid Leukemia Pathogenesis  \nDerya Demir   \nCitation: Demir, D. Insights into the New Molecular Updates in Acute Myeloid Leukemia Pathogenesis. Genes 2023, 14, 1424. [https://](https://)[ ](https://)[doi.org/10.3390/genes14071424](doi.org/10.3390/genes14071424)  \nAcademic Editors: Nicholas J. Short and Ken-Hong Lim  \nReceived: 30 April 2023  \nRevised: 28 June 2023  \nAccepted: 8 July 2023  \nPublished: 10 July 2023  \nCopyright: © 2023 by the author. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) .  \nDepartment of Pathology, Ege University Faculty of Medicine, Izmir 35100, Turkey; [derya.demir@ege.edu.tr](derya.demir@ege.edu.tr)  \n[Abstract:](Abstract: As our understanding of the biologic basis of acute myeloid leukemia evolves)[ As our understanding of the biologic basis of acute myeloid leukemia evolves](Abstract: As our understanding of the biologic basis of acute myeloid leukemia evolves), [so do the](so do the)[ ](so do the)[classi](classi)fi[cation systems used to describe this group of cancers](cation systems used to describe this group of cancers). Early classification systems focused on the morphologic features of blasts and other cell populations; however, the explosion in genomic technologies has led to rapid growth in our understanding of these diseases and thus the refinement of classification systems. Recently, two new systems, the International Consensus Classification system and the 5th edition of the World Health Organization classification of tumors of hematopoietic and lymphoid tissues, were published to incorporate the latest genomic advances in blood cancer. This article reviews the major updates in acute myeloid leukemia in both systems and highlights the biologic insights that have driven these changes.  \nKeywords: acute myeloid leukemia; pathogenesis; molecular updates; genomics  \n1. Introduction  \nAcute myeloid leukemia (AML) is a heterogeneous group of hematopoietic malignancies characterized by a proliferation of immature cells (blasts) . Early classification systems were based primarily on the morphologic features of these blasts, while in the last two decades, the predominant classification systems by the World Health Organization (WHO) have increasingly incorporated immunophenotypic and genetic characteristics to refine these groupings. The last major update to this classification occurred in 2016 with the revised 4th edition of the WHO classification of tumors of hematopoietic and lymphoid tissues [1] .  \nThe revised 4th edition WHO classification system (WHO4R) included several genetically defined subtypes of AML, specifically “AML with recurrent genetic abnormalities (AML-RGA)”, a subset of “AML with myelodysplasia-related changes (AML-MRC)”, and“AML with germline predisposition” [1] . Since the publication of this system, genomic testing has rapidly expanded, and with it, our understanding of the genetic underpinnings of AML. This more nuanced understanding has catalyzed efforts to refine the classification systems, which have been undertaken both by the WHO as part of the WHO 5th edition classification [2] and by the Society of Hematopathology (SH), European Association for Hematopathology (EAHP), and Clinical Advisory Committees (CAC) as the international consensus classification (ICC) [3,4] .  \nThese two classifications, the 5th edition of the WHO (WHO5) and the ICC, retain much of the overall structure of the prior AML genetic subtypes, with the persistence of the above three categories based on (1) recurrent genetic abnormalities,(2) myelodysplasiaassociated genetic changes, albeit both new classifications recognize specific mutations as myelodysplasia-related, and (3) germline pred","cbCainpZSftJIua4","https://ap.wps.com/l/cbCainpZSftJIua4","pdf",993312,16,"English","# Introduction\n# AML with Recurrent Genetic Abnormalities\n## RUNX1 Mutations","[{\"question\":\"Why have acute myeloid leukemia classification systems changed in recent years?\",\"answer\":\"The review explains that advances in genomic technologies increased knowledge of disease biology, prompting refinement of classification systems beyond morphology.\"},{\"question\":\"Which two new classification systems are emphasized?\",\"answer\":\"The article highlights the International Consensus Classification (ICC) and the 5th edition of the World Health Organization (WHO5) classification.\"},{\"question\":\"What is the role of RUNX1 in the updated AML framework?\",\"answer\":\"RUNX1 encodes a transcription factor essential for hematopoietic differentiation, and the review discusses how new classification entities handle RUNX1-related alterations, including changes to blast threshold discussions for RUNX1 mutation cases.\"}]","Insights into the New Molecular Updates in Acute Myeloid Leukemia Pathogenesis | PDF",1790272253]