[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-332156-105":59,"doc-detail-332156-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","insights-into-polycrystalline-microstructure-of-blood-films-with-3d-mueller-matrix-imaging-approach","Insights into polycrystalline microstructure of blood films with 3D Mueller matrix imaging approach","","Introduces a minimally invasive liquid-biopsy approach using 3D Mueller matrix (MM) image reconstruction to analyze dehydrated blood smear polycrystalline structures. The method exploits optical anisotropy changes in blood proteins during early disease stages, producing distinct patterns in dried blood droplets. Layer-by-layer analysis is performed via polarization-holographic and differential MM techniques to separate healthy and prostate-cancer samples. Quantitative optical anisotropy maps are evaluated using statistical moments to characterize birefringence and dichroism distributions, achieving high early diagnosis and staging accuracy.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/insights-into-polycrystalline-microstructure-of-blood-films-with-3d-mueller-matrix-imaging-approach/332156/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/insights-into-polycrystalline-microstructure-of-blood-films-with-3d-mueller-matrix-imaging-approach/332156.png","ImageObject",300,407,{"name":92,"@type":93},"Hazel","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-31","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":34},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is the core technique used to analyze blood films?","Question",{"text":112,"@type":113},"The study uses 3D Mueller matrix (MM) image reconstruction, combined with polarization-holographic and differential MM methods, to analyze dehydrated blood smear polycrystalline structures.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Why are optical anisotropy changes important in this approach?",{"text":117,"@type":113},"Blood proteins undergo structural alterations at quaternary and tertiary levels early in disease, which creates distinct patterns in the dried blood droplet microstructure.",{"name":119,"@type":110,"acceptedAnswer":120},"How does the method distinguish healthy individuals from cancer patients?",{"text":121,"@type":113},"It extracts optical anisotropy parameters from partially depolarizing dry blood smears and compares the resulting spatial and statistical characteristics of birefringence and dichroism maps.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},332156,1790332899,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":34,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":46,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":31,"preview_page_count":4},137441390410,"https://ap-avatar.wpscdn.com/avatar/2000252f4ab5702993?_k=1776741390130283984","[www. nature.com/scientificreports](www. nature.com/scientificreports)  \nOPEN  \nInsights into polycrystalline microstructure of blood films with 3D Mueller matrix imaging approach  \nAlexander G. Ushenko1,2, Anton Sdobnov3, Irina V. Soltys2, YuriyA. Ushenko4,5, Alexander V. Dubolazov2, Valery M. Sklyarchuk2, Alexander V. Olar2, Liliya Trifonyuk6, Alexander Doronin7, Wenjun Yan1, Alexander Bykov3 & Igor Meglinski8*  \nThis study introduces a novel approach in the realm of liquid biopsies, employing a 3D Muellermatrix (MM) image reconstruction technique to analyze dehydrated blood smear polycrystalline structures. Our research centers on exploiting the unique optical anisotropy properties of blood proteins, which undergo structural alterations at the quaternary and tertiary levels in the early stages of diseases such as cancer. These alterations manifest as distinct patterns in the polycrystalline microstructure of dried blood droplets, offering a minimally invasive yet highly effective method for early disease detection. We utilized a groundbreaking 3D MM mapping technique, integrated with digital holographic reconstruction, to perform a detailed layer-by-layer analysis of partially depolarizing dry blood smears. This method allows us to extract critical optical anisotropy parameters, enabling the differentiation of blood films from healthy individuals and prostate cancer patients. Our technique uniquely combines polarization-holographic and differential MM methodologies to spatially characterize the 3D polycrystalline structures within blood films. A key advancement in our study is the quantitative evaluation of optical anisotropy maps using statistical moments (first to fourth orders) of linear and circular birefringence and dichroism distributions. This analysis provides a comprehensive characterization of the mean, variance, skewness, and kurtosis of these distributions, crucial for identifying significant differences between healthy and cancerous samples. Our findings demonstrate an exceptional accuracy rate of over 􀀞􀀝 for the early diagnosis and staging of cancer, surpassing existing screening methods. This high level of precision and the non-invasive nature of our technique mark a significant advancement in the field of liquid biopsies. It holds immense potential for revolutionizing cancer diagnosis, early detection, patient stratification, and monitoring, thereby greatly enhancing patient care and treatment outcomes. In conclusion, our study contributes a pioneering technique to the liquid biopsy domain, aligning with the ongoing quest for non-invasive, reliable, and efficient diagnostic methods. It opens new avenues for cancer diagnosis and monitoring, representing a substantial leap forward in personalized medicine and oncology.  \nKeywords Liquid biopsy, Polarized light, 3D Mueller matrix, Blood, Polycrystalline thin films, Birefringence, Cancer diagnosis  \nOver the past decades, there have been extensive studies on the formation of complex patterns arising during the evaporation of liquid droplets 1. Distinct patterns, including coffee rings 2, cracking 3, and gelation 4, have  \n1Taizhou Institute of Zhejiang University, Taizhou 310027, China. 2Optics and Publishing Department, Yuriy Fedkovych Chernivtsi National University, 2 Kotsiubynskyi Str., Chernivtsi 58002, Ukraine. 3Optoelectronics and Measurement Techniques, University of Oulu, P.O. Box 4500, 900014 Oulu, Finland. 4Department of Physics, Shaoxing University, Shaoxing, Zhejiang 312000, China. 5Computer Science Department, Yuriy Fedkovych Chernivtsi National University, 2 Kotsiubynskyi Str., Chernivtsi 58002, Ukraine. 6Rivne State Medical Center, 78 Kyivska Str., Rivne 33007, Ukraine. 7School of Engineering and Computer Science, Victoria University of Wellington, 6140 Wellington, New Zealand. 8College of Engineering and Physical Sciences, Aston University,  \nBirmingham B4 7ET, UK.* email: [i.meglinski@aston.ac.uk](i.meglinski@aston.ac.uk)  \n[www. nature.com/scie","cbCainAdjFCr8jhZ","https://ap.wps.com/l/cbCainAdjFCr8jhZ","pdf",8165879,"English","# Overview\n## Study objective and rationale\n## 3D Mueller matrix imaging methodology\n## Optical anisotropy mapping and statistics\n## Evaluation and diagnostic implications","[{\"question\":\"What is the core technique used to analyze blood films?\",\"answer\":\"The study uses 3D Mueller matrix (MM) image reconstruction, combined with polarization-holographic and differential MM methods, to analyze dehydrated blood smear polycrystalline structures.\"},{\"question\":\"Why are optical anisotropy changes important in this approach?\",\"answer\":\"Blood proteins undergo structural alterations at quaternary and tertiary levels early in disease, which creates distinct patterns in the dried blood droplet microstructure.\"},{\"question\":\"How does the method distinguish healthy individuals from cancer patients?\",\"answer\":\"It extracts optical anisotropy parameters from partially depolarizing dry blood smears and compares the resulting spatial and statistical characteristics of birefringence and dichroism maps.\"}]","Insights into polycrystalline microstructure of blood films with 3D Mueller matrix imaging approach | PDF",1789997082]