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Evidence shows bacteria can migrate across body compartments and colonize structurally different sites during colorectal cancer (CRC) genesis and progression. The oral microbiome may penetrate the large intestine, promoting dysbiosis and cancerogenic processes. Key drivers include red and orange complex periodontal pathogens such as Porphyromonas gingivalis and Fusobacterium nucleatum, linked to virulence factors. Further study could enable early CRC detection via precise noninvasive biomarkers.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/insights-into-oral-microbiome-and-colorectal-cancer-on-the-way-of-searching-new-perspectives/382310/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/insights-into-oral-microbiome-and-colorectal-cancer-on-the-way-of-searching-new-perspectives/382310.png","ImageObject",300,407,{"name":92,"@type":93},"Liam","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":52},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What role does the microbiome play in human health and disease?","Question",{"text":112,"@type":113},"The microbiome supports homeostasis and contributes to defense against infection and nutrient absorption. It can also lead to detrimental effects depending on context and composition.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How might the oral microbiome be related to colorectal cancer?",{"text":117,"@type":113},"The oral microbiome is described as capable of penetrating the large intestine, causing impairments that lead to dysbiosis and stimulation of cancerogenic processes.",{"name":119,"@type":110,"acceptedAnswer":120},"Which oral bacteria are highlighted as key contributors to CRC-associated mechanisms?",{"text":121,"@type":113},"The article points to periodontal pathogenic bacteria from the red and orange complex, including Porphyromonas gingivalis and Fusobacterium nucleatum, noted for significant cancerogenic virulence factors.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},382310,1790790063,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":52,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":39,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":46},8796095461564,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","TYPE Review  \nPUBLISHED 12 April 2023  \nDOI 10.3389/fcimb.2023.1159822  \nOPEN ACCESS  \nEDITED BY Steven Gill,  \nUniversity of Rochester, United States  \nREVIEWED BY  \nZackary Fitzsimonds,  \nUniversity of Michigan, United States Yuichiro Noiri,  \nNiigata University, Japan  \n*CORRESPONDENCE  \nKarolina Kaz´mierczak-Siedlecka  \n [leokadia@gumed.edu.pl](leokadia@gumed.edu.pl)  \nSPECIALTY SECTION  \nThis article was submitted to Microbiome in Health and Disease, a section of the journal  \nFrontiers in Cellular and Infection Microbiology  \nRECEIVED 06 February 2023  \nACCEPTED 28 March 2023  \nPUBLISHED 12 April 2023  \nCITATION  \nKudra A, Muszyn´ski D, Sobocki BK, Atzeni A, Carbone L, Kaz´mierczakSiedlecka K, Połom K and Kalinowski L (2023) Insights into oral microbiome and colorectal cancer – on the way of searching new perspectives.  \nFront. Cell. Infect. Microbiol. 13:1159822 .  \ndoi: 10.3389/fcimb.2023.1159822  \nCOPYRIGHT  \n© 2023 Kudra, Muszyn´ski, Sobocki, Atzeni, Carbone, Kaz´mierczak-Siedlecka, Połom and Kalinowski. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.  \nInsights into oral microbiome and colorectal cancer – on the way of searching new perspectives  \nAnna Kudra 1, Damian Muszy ´nski 1, Bartosz Kamil Sobocki 2, Alessandro Atzeni 3,4,5, Ludovico Carbone 6,  \nKarolina Ka´zmierczak-Siedlecka 7*, Karol Połom 8 and Leszek Kalinowski 7,9  \n1Scientific Circle of Studies Regarding Personalized Medicine Associated with Department of Medical Laboratory Diagnostics, Medical University of Gdansk, Gdansk, Poland, 2Scientific Circle of Oncology and Radiotherapy, Medical University of Gdansk, Gdansk, Poland, 3 Institut d’ Investigacio´ Sanitària Pere Virgili (IISPV), Reus, Spain, 4 Universitat Rovira i Virgili, Departament de Bioqumica i Biotecnologia, Unitat de Nutricio´, Reus, Spain, 5Centro de Investigacio´ n Biome´ dica en Red Fisiopatologa de la Obesidad y la Nutricio´n (CIBEROBN), Institute of Health Carlos III, Madrid, Spain, 6 Department of Medicine Surgery and Neuroscience, University of Siena, Siena, Italy, 7 Department of Medical Laboratory Diagnostics – Fahrenheit Biobank [BBMRI.pl](BBMRI.pl), Medical University of Gdansk, Gdansk, Poland, 8 Department of Surgical Oncology, Medical University of Gdansk, Gdansk, Poland, 9 BioTechMed Centre, Department of Mechanics of Materials and Structures, University of Technology,  \nGdansk, Poland  \nMicrobiome is a keystone polymicrobial community that coexist with human body in a beneficial relationship. These microorganisms enable the human body to maintain homeostasis and take part in mechanisms of defense against infection and in the absorption of nutrients. Even though microbiome is involved in physiologic processes that are beneficial to host health, it may also cause serious detrimental issues. Additionally, it has been proven that bacteria can migrate to other human body compartments and colonize them even although significant structural differences with the area of origin exist. Such migrations have been clearly observed when the causes of genesis and progression of colorectal cancer (CRC) have been investigated. It has been demonstrated that the oral microbiome is capable of penetrating into the large intestine and cause impairments leading to dysbiosis and stimulation ofcancerogenic processes. The main actors of such events seem to be oral pathogenic bacteria belonging to the red and orange complex (regarding classification of bacteria in the context of periodontal diseases), such as Porphyromonas gingivalis and Fusobacterium nucleatum respectively, which are characterized by significant a","cbCaikGLjThSXmi6","https://ap.wps.com/l/cbCaikGLjThSXmi6","pdf",1988507,"English","# 1 Introduction\n## Colorectal cancer burden and risk factors\n## Links between microbiome alterations and CRC","[{\"question\":\"What role does the microbiome play in human health and disease?\",\"answer\":\"The microbiome supports homeostasis and contributes to defense against infection and nutrient absorption. It can also lead to detrimental effects depending on context and composition.\"},{\"question\":\"How might the oral microbiome be related to colorectal cancer?\",\"answer\":\"The oral microbiome is described as capable of penetrating the large intestine, causing impairments that lead to dysbiosis and stimulation of cancerogenic processes.\"},{\"question\":\"Which oral bacteria are highlighted as key contributors to CRC-associated mechanisms?\",\"answer\":\"The article points to periodontal pathogenic bacteria from the red and orange complex, including Porphyromonas gingivalis and Fusobacterium nucleatum, noted for significant cancerogenic virulence factors.\"}]","Insights into oral microbiome and colorectal cancer - on the way of searching new perspectives | PDF",1790249983]