[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-375796-105":59,"doc-detail-375796-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","insights-into-cancer-associated-thrombosis-leading-towards-ischemic-stroke","Insights into Cancer-Associated Thrombosis Leading Towards Ischemic Stroke","","Stroke causes substantial disability, while cancer increases the likelihood of stroke. Cancer-associated stroke (CAS) is expected to grow as cancer therapies improve. Multiple cancer types have been linked to ischemic stroke, with potential direct effects on stroke pathophysiology or indirect effects via coagulation and other contributors such as infections. Treatments including chemotherapy, radiotherapy, and surgery are also associated with higher stroke risk.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/insights-into-cancer-associated-thrombosis-leading-towards-ischemic-stroke/375796/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/insights-into-cancer-associated-thrombosis-leading-towards-ischemic-stroke/375796.png","ImageObject",300,407,{"name":92,"@type":93},"Mia  ","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-26","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":34},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is cancer-associated stroke and why does cancer increase stroke risk?","Question",{"text":112,"@type":113},"Cancer-associated stroke refers to stroke occurring in the context of cancer. Cancer can increase clotting, and the resulting clots can block blood flow to the brain, leading to stroke.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How is ischemic stroke connected to thrombosis and embolism?",{"text":117,"@type":113},"Ischemic stroke occurs when brain blood flow is blocked or reduced. This can happen when a thrombosis or an embolism prevents adequate oxygen and nutrient delivery to brain tissue.",{"name":119,"@type":110,"acceptedAnswer":120},"What does the review cover about cancer patients who develop ischemic stroke?",{"text":121,"@type":113},"The review discusses subtypes, epidemiology, pathophysiology, mechanisms, biomarkers, and signaling pathways, and it also addresses involved transcription factors as well as treatment and patient management needs.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},375796,1790522402,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":34,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},687207024478,"https://ap-avatar.wpscdn.com/davatar_a8503ba1806abce46bf441b54a3ca4cd","Review  \nInsights into Cancer-Associated Thrombosis Leading Towards Ischemic Stroke  \nSurajit Hansda  and Hiranmoy Das *  \nAcademic Editor: Huaxin Sheng  \nReceived: 20 December 2024  \nRevised: 7 January 2025  \nAccepted: 9 January 2025  \nPublished: 10 January 2025  \nCitation: Hansda, S.; Das, H. Insights into Cancer-Associated Thrombosis Leading Towards Ischemic Stroke. Biology 2025, 14, 50. [https://doi.org/](https://doi.org/)[ ](https://doi.org/)[10.3390/biology14010050](10.3390/biology14010050)  \nCopyright: © 2025 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://creativecommons.org/](https://creativecommons.org/)[ ](https://creativecommons.org/)[licenses/by/4.0/](licenses/by/4.0/)) .  \nDepartment of Pharmaceutical Sciences, Jerry H. Hodge School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, TX 79106, USA  \n* [Correspondence: hiranmoy.das@ttuhsc.edu](Correspondence: hiranmoy.das@ttuhsc.edu); Tel.: +1-806-414-9623; Fax: +1-806-356-4770  \nSimple Summary: Cancer increases the risk of stroke due to the increment of blood clotting caused by cancer. These clots block blood flow to the brain, causing a stroke. Additionally, cancer therapy, including chemotherapy and radiation, surgery, hormonal therapy, and central venous catheters, increases the risk. Detection of cancer-associated stroke is challenging because it happens suddenly and does not show typical stroke symptoms. Understanding the link between cancer and stroke helps to improve diagnosis, develop prevention strategies, and support patient care.  \nAbstract: Stroke leads to significant disability in most patients, whereas cancer elevates the occurrence of stroke. The incidence of cancer-associated stroke (CAS) is projected to rise as a result of improvements in cancer therapies. Various forms of cancer have been demonstrated to be linked to ischemic stroke. Cancer might influence stroke pathophysiology either directly or through coagulation that creates a hypercoagulative state, in addition to infections. Treatment methods for cancer, including chemotherapy, radiotherapy, and surgery, have all been demonstrated to increase the risk of stroke as well. This review discusses the subtypes, epidemiology, pathophysiology, mechanisms of stroke within cancer patients, biomarkers, and signaling pathways of stroke in cancer while providing vital information on the involved transcription factors, treatment, and management of patients with cancer-associated ischemic stroke. Atherosclerosis, extracellular vesicles (EVs), and signaling biomolecules can also affect CAS. Overall, stroke is a significant and not uncommon complication of cancer, and there is an immediate demand for neurologists and oncologists to create strategies for screening and preventing strokes in cancer patients.  \nKeywords: cancer-associated stroke; cancer; ischemic stroke; thrombosis; coagulopathy  \n1. Introduction  \nThe estimated lifetime incidence of cancer is around 40%, with around 2 million new cancer cases and 609,820 cancer deaths occurring in the United States in the year 2023 [1] . Cancer remains one of the leading causes of death worldwide, and its impact is widespread across societies, economies, and healthcare systems. The burden of cancer is rising, not only due to an aging population but also because of several factors that contribute to cancer’s growing impact, including lifestyle factors, environmental exposures, and the increasing complexity of the disease itself. Cancer treatment faces several significant challenges, such as tumor heterogeneity, resistance to treatment, early detection and diagnosis, side effects of treatment, immunotherapy complications, etc., that impact its effectiveness, accessibility, and outcomes. Therefore, long-term quality of life has become more important  \nfor cancer patients, making the prevention of dis","cbCair4FfAZa9PTq","https://ap.wps.com/l/cbCair4FfAZa9PTq","pdf",956100,17,"English","# Introduction\n## Stroke types and etiologies\n## Overlapping risk factors\n# Cancer-associated stroke (CAS)\n## Mechanistic links between cancer and ischemic stroke\n## Coagulation and hypercoagulable states\n# Research focus and clinical needs\n## Subtypes, epidemiology, pathophysiology, mechanisms\n## Biomarkers and signaling pathways","[{\"question\":\"What is cancer-associated stroke and why does cancer increase stroke risk?\",\"answer\":\"Cancer-associated stroke refers to stroke occurring in the context of cancer. Cancer can increase clotting, and the resulting clots can block blood flow to the brain, leading to stroke.\"},{\"question\":\"How is ischemic stroke connected to thrombosis and embolism?\",\"answer\":\"Ischemic stroke occurs when brain blood flow is blocked or reduced. This can happen when a thrombosis or an embolism prevents adequate oxygen and nutrient delivery to brain tissue.\"},{\"question\":\"What does the review cover about cancer patients who develop ischemic stroke?\",\"answer\":\"The review discusses subtypes, epidemiology, pathophysiology, mechanisms, biomarkers, and signaling pathways, and it also addresses involved transcription factors as well as treatment and patient management needs.\"}]","Insights into Cancer-Associated Thrombosis Leading Towards Ischemic Stroke | PDF",1790216158,43]