[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-367459-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-367459-en":131},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","innovative-approaches-in-bone-tissue-engineering-strategies-for-cancer-treatment-and-recovery","Innovative Approaches in Bone Tissue Engineering - Strategies for Cancer Treatment and Recovery","","Cancer has rapidly emerged as a leading global cause of premature mortality, with major economic consequences projected to reach USD 25.2 trillion from 2020 to 2050. Primary bone cancers, though relatively rare, are expected to account for nearly 4000 new United States diagnoses in 2024. Treatment complexity stems from rarity, heterogeneity, surgical limitations, metastatic spread, and post-operative complications. Bone tissue engineering advances therapeutic strategies to promote regeneration and reduce tumor recurrence using biomaterials, scaffolds, gene therapy, 3D bioprinting, biodegradable bioactive materials, and nanotechnology-based targeted delivery.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/innovative-approaches-in-bone-tissue-engineering-strategies-for-cancer-treatment-and-recovery/367459/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/innovative-approaches-in-bone-tissue-engineering-strategies-for-cancer-treatment-and-recovery/367459.png","ImageObject",300,407,{"name":42,"@type":43},"Alex Sinclair","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-11-02","2026-09-23",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",17,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"Why is treating primary bone cancer particularly challenging?","Question",{"text":63,"@type":64},"Primary bone cancers are uncommon and heterogeneous, and treatment is complicated by surgical challenges, metastatic spread, and post-operative complications such as recurrence and infection.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How does bone tissue engineering support cancer treatment and recovery?",{"text":68,"@type":64},"Bone tissue engineering uses biomaterials, scaffolds, cells, and regulatory signals to promote site-specific structural and biological outcomes, enabling bone regeneration and helping address tumor recurrence.",{"name":70,"@type":61,"acceptedAnswer":71},"What technologies are highlighted for advancing scaffold-based therapies?",{"text":72,"@type":64},"The review emphasizes scaffold fabrication and approaches such as 3D bioprinting for custom scaffolds, biodegradable bioactive materials for improved compatibility, and nanotechnology for targeted drug delivery.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},367459,1790217788,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,110,115,120,123,127],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":108,"slug":109},7,40,"healthcare",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":112,"show_sort_weight":113,"slug":114},8,"Research & Report",30,"research-report",{"id":116,"doc_module":4,"doc_module_name":25,"category_name":117,"show_sort_weight":118,"slug":119},9,"Religion & Spirituality",20,"religion-spirituality",{"id":118,"doc_module":4,"doc_module_name":25,"category_name":121,"show_sort_weight":118,"slug":122},"World Cup","world-cup",{"id":124,"doc_module":4,"doc_module_name":25,"category_name":125,"show_sort_weight":124,"slug":126},10,"Lifestyle","lifestyle",{"id":128,"doc_module":4,"doc_module_name":25,"category_name":129,"show_sort_weight":97,"slug":130},19,"General","general",{"code":4,"msg":82,"data":132},{"doc_id":79,"user_id":133,"nickname":42,"user_avatar":134,"doc_module":4,"category_id":107,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":140,"language":141,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":142,"faqs":143,"seo_title":144,"seo_description":12,"update_tm":145,"read_time":146},1099523882182,"https://ap-avatar.wpscdn.com/davatar_6f874abed73319feea01a86fa6f0fab8","Review  \nInnovative Approaches in Bone Tissue Engineering: Strategies for Cancer Treatment and Recovery  \nSamiksha S. Khobragade, Manish Deshmukh, Ujwal Vyas and Rahul G. Ingle *  \nAcademic Editor: Xiao Hu  \nReceived: 9 December 2024  \nRevised: 23 December 2024  \nAccepted: 31 December 2024  \nPublished: 22 April 2025  \nCitation: Khobragade, S.S.;  \nDeshmukh, M.; Vyas, U.; Ingle, R.G. Innovative Approaches in Bone Tissue Engineering: Strategies for Cancer Treatment and Recovery. Int. J. Mol. Sci. 2025, 26, 3937. [https://doi.org/](https://doi.org/)[ ](https://doi.org/)[10.3390/ijms26093937](10.3390/ijms26093937)  \nCopyright: © 2025 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://creativecommons.org/](https://creativecommons.org/)[ ](https://creativecommons.org/)[licenses/by/4.0/](licenses/by/4.0/)) .  \nDatta Meghe College of Pharmacy, Datta Meghe Institute of Higher Education and Research, Sawangi (M), Wardha 442001, India  \n* Correspondence: [rahul.pharmacy@dmiher.edu.in](rahul.pharmacy@dmiher.edu.in); Tel.: +91-99-23-16932  \nAbstract: Cancer has rapidly emerged as a leading global cause of premature mortality, with significant economic implications projected to reach USD 25.2 trillion from 2020 to 2050. Among the various types of cancer, primary bone cancers, though uncommon, are projected to see nearly 4000 new cases diagnosed in the United States in 2024 . The complexity of treating bone cancer arises from its rarity, diversity, and the challenges associated with surgical interventions, metastatic spread, and post-operative complications. Advancementsin bone tissue engineering (BTE) have introduced innovative therapeutic approaches to promote bone regeneration and address tumor recurrence. This interdisciplinary field integrates biomaterials, scaffolds, and gene therapy, utilizing technologies such as 3Dbioprinting to create custom scaffolds that facilitate cellular activities essential for tissue regeneration. Recent developments in biodegradable, bioactive materials aim to enhance the biocompatibility and effectiveness of scaffolds, while nanotechnology presents promising avenues for targeted drug delivery and improved therapeutic outcomes. This review outlines the current landscape of BTE, highlighting scaffold fabrication techniques, the advantages of incorporating stem cell and gene therapies, and future directions, including the integration of artificial intelligence in scaffold design for personalized medicine in orthopedic oncology. This work underscores the necessity for ongoing research and innovation, aiming to improve therapeutic strategies specifically designed to address the unique challenges posed by bone sarcomas and metastatic cancers.  \nKeywords: artificial intelligence; bone tissue engineering; 3D printing; gene therapy; metastasis; scaffold fabrication; stem cells  \n1. Introduction  \nCancer is emerging as a leading cause of premature death worldwide [1] . The significant worldwide economic burden of cancer from 2020 to 2050 is anticipated to reach USD 25.2 trillion [2] . The American Cancer Society estimates that there will be approximately 3970 new cases of primary cancer of the bones and joints in 2024, with 2270 cases in males and 1700 in females. It also estimates about 2050 deaths from this cancer (1100 in males and 950 in females) . Osteosarcoma is the most common type of primary bone cancer, followed by chondrosarcoma and Ewing sarcomas [3] .  \nBone tumors, which invade bone tissue, can be categorized as primary or metastatic [4] . The major treatment method for bone cancer is surgical excision of malignancies. Preoperative therapies, especially post-operative adjuvant anticancer methods, are critical for achieving excellent therapeutic outcomes. However, the occurrence of post-operative bone tumor recurrence, metastasis, substantial bone abnormalities, ","cbCaihreDbJiItFL","https://ap.wps.com/l/cbCaihreDbJiItFL","pdf",4055939,21,"English","# Introduction\n## Bone cancer burden and diagnosis\n## Challenges in surgical treatment and recurrence\n## Role of tissue engineering and review purpose","[{\"question\":\"Why is treating primary bone cancer particularly challenging?\",\"answer\":\"Primary bone cancers are uncommon and heterogeneous, and treatment is complicated by surgical challenges, metastatic spread, and post-operative complications such as recurrence and infection.\"},{\"question\":\"How does bone tissue engineering support cancer treatment and recovery?\",\"answer\":\"Bone tissue engineering uses biomaterials, scaffolds, cells, and regulatory signals to promote site-specific structural and biological outcomes, enabling bone regeneration and helping address tumor recurrence.\"},{\"question\":\"What technologies are highlighted for advancing scaffold-based therapies?\",\"answer\":\"The review emphasizes scaffold fabrication and approaches such as 3D bioprinting for custom scaffolds, biodegradable bioactive materials for improved compatibility, and nanotechnology for targeted drug delivery.\"}]","Innovative Approaches in Bone Tissue Engineering - Strategies for Cancer Treatment and Recovery | PDF",1790170865,53]