[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-594824-105":59,"doc-detail-594824-en":129},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":122,"head_meta":124,"extra_data":126,"updated_unix":128},105,"en","innovations-using-cancer-staging-to-teach-about-tissue-layers","Innovations - Using Cancer Staging to Teach about Tissue Layers","","Histological assessment of tissues underpins disease diagnosis and staging, yet students often learn tissue layers by memorization without real clinical context. The activity presented is a hands-on, inquiry-based lab where students stain provided bladder tissue from two patients, one normal and one with bladder cancer. Students diagnose the diseased sample and assign a cancer stage using tumor-infiltrating tissue layers. They then assemble pathology reports from microscope or phone images and compare them with professional reports, reinforcing the value of tissue-layer knowledge.",{"@graph":69,"@context":121},[70,84,104],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/innovations-using-cancer-staging-to-teach-about-tissue-layers/594824/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":98,"encodingFormat":97,"isAccessibleForFree":99,"interactionStatistic":100},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/innovations-using-cancer-staging-to-teach-about-tissue-layers/594824.png","ImageObject",300,407,{"name":92,"@type":93},"Mary Man","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-15",true,{"@type":101,"interactionType":102,"userInteractionCount":4},"InteractionCounter",{"@type":103},"ViewAction",{"@type":105,"mainEntity":106},"FAQPage",[107,113,117],{"name":108,"@type":109,"acceptedAnswer":110},"How do students determine whether a bladder tissue sample is diseased?","Question",{"text":111,"@type":112},"Students use their knowledge of normal bladder tissue and assess the stained sections to decide which sample is diseased and what disease it represents.","Answer",{"name":114,"@type":109,"acceptedAnswer":115},"How is cancer stage assigned in the activity?",{"text":116,"@type":112},"Cancer staging is determined by identifying which tissue layers the tumor has infiltrated, aligned with commonly used bladder cancer staging guidelines (TNM).",{"name":118,"@type":109,"acceptedAnswer":119},"What materials and workflow are used during the lab periods?",{"text":120,"@type":112},"Lab Period 1 focuses on preparing and completing H&E staining, while Lab Period 2 centers on visualizing stained tissues, capturing images via microscope/camera, and assembling pathology reports for comparison with professional reports.","https://schema.org",{"og:url":83,"og:type":123,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":125,"canonical":83},"index,follow",{"doc_id":127,"site_id":62},594824,1792079918,{"code":4,"msg":5,"data":130},{"doc_id":127,"user_id":131,"nickname":92,"user_avatar":132,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":133,"file_id":134,"file_url":135,"file_type":136,"file_size":137,"view_count":4,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":24,"language":138,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":139,"faqs":140,"seo_title":141,"seo_description":67,"update_tm":128,"read_time":142},7421720224475,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","Innovations  \nUsing Cancer Staging to Teach about Tissue Layers  \nKurt M. Lucin  \nBiology Department, Eastern Connecticut State University, 83 Windham Street, Willimantic, CT 06226  \nAbstract: Histological assessment of tissues is a critical component of diagnosing diseases and determining disease severity or stage. In order to fully appreciate tissue pathology, an understanding of healthy tissue layers is required. Students traditionally learn this information by memorizing different layers within healthy tissue. This is often a daunting task if not placed into a meaningful real-world context. Described here is a hands-on inquiry-based laboratory where students make a diagnosis based on their knowledge of tissue layers. Students are provided readily available preserved tissue from two patients. Students are unaware that one patient is normal while the other has bladder cancer. Students stain the tissues using a common histological technique and are responsible for providing a bladder cancer diagnosis with corresponding cancer stage. This activity not only provides real-world technical experience, but since cancer staging is determined by the tissue layers the tumor has infiltrated, it also reinforces the importance of knowing different tissue layers. Following their diagnosis, pathology reports are assembled using images from either a microscope or cell phone. Students then compare these results with professional pathology reports accompanying the tissue. This activity is well suited for health sciences, cancer biology, histology, or pathology classes.  \nKey words: Histology, cancer, pathology  \nIntroduction  \nTeaching students about basic histological features oftissues can be a challenging task. This is often accomplished by asking students to observe and memorize various layers using prepared slides of healthy tissue. However, many students have trouble retaining this information or appreciating its value when not connected to a medical application. Conversely, students are much more engaged in learning about tissue layers after their importance in disease diagnosis becomes clear. Described is an inquiry-based learning activity where students identify different tissue layers and compare normal vs. pathological cancer tissues. While cancer could be explored in various organs, bladder cancer is an ideal tissue type for this activity. A bladder cancer diagnosis requires the ability to recognize abnormal tissue and the severity/stage of the cancer is determined by identifying which tissue layers the tumor has infiltrated, as described by commonly used cancer staging guidelines (the Tumor-NodeMetastasis (TNM) Staging System) . Bladder cancer is also the 9th most commonly diagnosed cancer worldwide and the 13th most common cause of death (Antoni et al., 2016), thus highlighting the importance of its diagnosis. Importantly, stained and unstained bladder cancer tissue is readily available for purchase at various tissue repositories.  \nThe goal of this inquiry-based activity is for students to assess and diagnose bladder tissue samples. To do this, students are provided tissue from  \ntwo separate patients experiencing various symptoms. While the symptoms for both patients are provided to students, diagnoses are not provided. Students then stain these tissues using hematoxylin and eosin (H&E) to visualize tissue composition. Using their knowledge of normal bladder tissue, students determine which tissue is diseased and what disease that patient has. This activity typically requires two lab periods. The first lab period is devoted to completing the H&E stain. In the second lab period, students visualize and assess their stained tissues. Students also acquire images of their tissues by placing a cell phone to the oculars ofthe microscope or by using a dedicated microscopy camera. These images are then used to assemble a pathology report (see report outline below) .  \nMethods and Materials  \nLab Period 1  \nActivity Introduction: To pre","cbCaicO9bNHvE6br","https://ap.wps.com/l/cbCaicO9bNHvE6br","pdf",453270,"English","# Abstract\n# Introduction\n# Methods and Materials\n## Lab Period 1\n## Bladder Tissues\n## Description of Patient Samples\n## Hematoxylin and Eosin Staining","[{\"question\":\"How do students determine whether a bladder tissue sample is diseased?\",\"answer\":\"Students use their knowledge of normal bladder tissue and assess the stained sections to decide which sample is diseased and what disease it represents.\"},{\"question\":\"How is cancer stage assigned in the activity?\",\"answer\":\"Cancer staging is determined by identifying which tissue layers the tumor has infiltrated, aligned with commonly used bladder cancer staging guidelines (TNM).\"},{\"question\":\"What materials and workflow are used during the lab periods?\",\"answer\":\"Lab Period 1 focuses on preparing and completing H\\u0026E staining, while Lab Period 2 centers on visualizing stained tissues, capturing images via microscope/camera, and assembling pathology reports for comparison with professional reports.\"}]","Innovations - Using Cancer Staging to Teach about Tissue Layers | PDF",13]