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The research, detailed in the journal Advanced Materials, demonstrated the concept by successfully inducing lung cells in mice to produce luciferase, a light-emitting protein, after they inhaled a polymer-packaged mRNA. This breakthrough signifies the potential of inhaled genetic therapy to initiate the production of new proteins. Scientists are further investigating this technique with a publicly traded biotech company, Translate Bio, which is currently conducting clinical trials to assess the efficacy of inhaled mRNA in providing a genetic solution for cystic fibrosis patients who suffer from mucus buildup due to a genetic mutation. The luciferase experiment serves as a foundational proof of concept for this promising therapeutic avenue, highlighting its potential to inspire future treatments for various genetic conditions beyond cystic fibrosis, by enabling targeted genetic revisions through a non-invasive respiratory delivery method.",{"@graph":69,"@context":105},[70,84],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/inhaled-rna-might-help-heal-cystic-fibrosis/24373/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/inhaled-rna-might-help-heal-cystic-fibrosis/24373.png","ImageObject",300,407,{"name":92,"@type":93},"Logic","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-09-18","2026-05-07",true,{"@type":102,"interactionType":103,"userInteractionCount":8},"InteractionCounter",{"@type":104},"ViewAction","https://schema.org",{"og:url":107,"og:type":108,"og:title":65,"og:site_name":95,"og:description":67},"https://docshare.wps.com/document/inhaled-rna-might-help-heal-cystic-fibrosis/24373","article",{"robots":110,"canonical":107},"index,follow",{"doc_id":112,"site_id":62},24373,1778188688,{"code":4,"msg":5,"data":115},{"doc_id":112,"user_id":116,"nickname":92,"user_avatar":117,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":66,"file_id":118,"file_url":119,"file_type":120,"file_size":121,"view_count":8,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":8,"language":122,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":66,"faqs":66,"seo_title":123,"seo_description":67,"update_tm":113,"read_time":81},1099513958762,"https://ap-avatar.wpscdn.com/avatar/1000023916a998db790?x-image-process=image/resize,m_fixed,w_180,h_180&k=1784791008015729253","cbCaibrGzqAmwnzo","https://ap.wps.com/l/cbCaibrGzqAmwnzo","pdf",188527,"English","Inhaled RNA Might Help Heal Cystic Fibrosis | PDF"]