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Lower body suction at -10 and -20 mmHg for 10 min lowered central venous pressure without changing arterial pressure, presumed to reduce low-pressure inhibition without affecting high-pressure inhibition, and did not increase renin. At -40 mmHg, pulse pressures decreased and renin increased from 2.1±0.4 to 7.4±1.4 ng·ml−1·hr−1 (P\u003C0.05). Combined reduction of both inhibitory inputs was required for increased renin.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/influence-of-low-and-high-pressure-baroreceptors-on-plasma-renin-activity-in-humans-abstract-and-study-findings/155650/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/influence-of-low-and-high-pressure-baroreceptors-on-plasma-renin-activity-in-humans-abstract-and-study-findings/155650.png","ImageObject",300,407,{"name":92,"@type":93},"Cipher","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-09-27","2026-08-28",true,{"@type":102,"interactionType":103,"userInteractionCount":29},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"How was plasma renin activity measured in the study?","Question",{"text":112,"@type":113},"Plasma renin activity was assessed using an immunoassay approach in six healthy men.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What effect did lower body suction at -10 and -20 mmHg have on renin?",{"text":117,"@type":113},"It decreased central venous pressure without changing arterial pressure, presumed to reduce low-pressure baroreceptor inhibition, but renin did not increase.",{"name":119,"@type":110,"acceptedAnswer":120},"When did renin increase, and what dose level caused it?",{"text":121,"@type":113},"Renin increased at -40 mmHg, when both central venous and arterial pulse pressure decreased, indicating reduced inhibition from both low- and high-pressure baroreceptors.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},155650,1787919849,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":29,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":129,"read_time":144},687208528416,"https://ap-avatar.wpscdn.com/davatar_9964176cb1d06d4a9deccf72a44ae3dc","# General Disclaimer\n\nOne or more of the Following Statements may affect this Document  \n·This document has been reproduced from the best copy furnished by theorganizational source.It is being released in the interest of making available asmuch information as possible.  \n·This document may contain data,which exceeds the sheet parameters.It wasfurnished in this condition by the organizational source and is the best copyavailable.  \n·This document may contain tone-on-tone or color graphs,charts and/or pictures,which have been reproduced in black and white.  \n·This document is paginated as submitted by the original source.  \n·Portions of this document are not fully legible due to the historical nature of someof the material.However,it is the best reproduction available from the originalsubmission.  \n《(  \n# Influence of Iow and High Pressure Baroreceptorson Plasma Renin Activity in Humans\n\nAllyn L。Mark,M.D.Francois M.Abboud,M.D.  \nand  \nAnnette E.Fitz,M.D.  \nFrom the Cardiovascular and C1inical Research Centers and theCardiovascular and Hypertension-Nephrology Division,Departnentof Internal Medicine,University of Iowa College of Medicine,and the Veterans Administration Hospital,Iowa City,IA 52242.  \nSupported by Clinical Investigatorships and a grant(MIRS5462)from the Veterans Administration and Program ProjectGrant HL-14388 and Research Grant HL-16149 from the NationalHeart and Lung Institute and Grant M01 RR59 from the GeneralClinical Research Centers Program,Division of ResearchResources,National Institutes of Health.  \nAddress proofs to;  Dr.Al1yn Mark  \nCardiovascular DivisionDepartment of MedicineUniversity HospitalsIowa City,IA 52242  \nMAD 1378  \nAbbreviated Tit3e:Reflex Control of Renin in Humans  \n(NASA-CR-155307)  INFLIJENCE OF LON AND HIGHPRESSUEE BARORECEPTORS ON PLASHA RENINACTIVITY IN HUEANS(Iova Univ.)  27 p HCA03/NF A01CSCL 06P  \nN78-18701  \nInclas  \nG3/52  06574  \n## Abstzact\n\nWe evaluated effects of low and high pressure baroreceptorson plasma renin activity(immunoassay)using graded lower bodysuction(LBS)in six healthy men.  LBS at -10 and -20 mmgfor 10 min decreaed centra3 venous pressure without changingarterial pressure and thereby presumably reduced 1ow but nothigh pressure baroreceptor inhibition of renin release.LBSat:these levels produced forearm vasoconstriction,but didnot increase renin.  LBS at -40 mmHg decreased central venousand arterial pulse pressure and thus reduced both low and highpressure baroreceptor inhibition.  LBS at this level producedforearm vasoconstriction and tachycardia and increased reninfrom 2.1±0.4(mean ±SE)to 7.4±1.4 ng:m1-¹·hr-¹(P \u003C0.05)。  In summary,reduction in low pressure baro-receptor inhibition in humans did not ircrease renin in thepresence of physiological tonic inhibition from high pressurebaroreceptors.  Increases in renin did not occur until therewas combined reduction of high and low pressure baroreceptorinhibition on plasma renin activity.  \n## Index Terms\n\nCardiopulmonary BaroreceptorsArterial BarozeceptorsForearm Blood Flow(Plethysmography)  \n一.  \nDecreaseo in baroreceptor restraint during upright posture  \n(4,8,23)or lower body suction(12,12)increase plasmarenin activity.These increases in renin activity play anessential role in maintenance of blood pressure during uprightposture in humans during low sodium intake(24).  \nSeveral studies have evaluated the reflex mechanismsinvolved in renin release.Experiments in animals suggestthat low pressure(cardiopu 1monary)baroreceptors may partici-pate in reflex regulation of plasma renin activity(3,18,20,  \n28,29,32)。  \nHowever,the role of high pressure(carotid and aortic)baroreceptors in reflex regulation of renin activity is unclear.Several investigators(7,17,29)have reported.that sinoaorticdenervation or bilateral carotid occlusion increases renin.Other investigators(2,20,25)have not observed an increasein renin with decreases in carotid sinus pressure.  \nJarecki,Thames and Donald(18)recently demonstratedan interaction be","cbCaiiGSMkV9IkKg","https://ap.wps.com/l/cbCaiiGSMkV9IkKg","pdf",790349,28,"English","# Abstract\n## Background and Rationale\n## Methods and Design\n## Findings Summary","[{\"question\":\"How was plasma renin activity measured in the study?\",\"answer\":\"Plasma renin activity was assessed using an immunoassay approach in six healthy men.\"},{\"question\":\"What effect did lower body suction at -10 and -20 mmHg have on renin?\",\"answer\":\"It decreased central venous pressure without changing arterial pressure, presumed to reduce low-pressure baroreceptor inhibition, but renin did not increase.\"},{\"question\":\"When did renin increase, and what dose level caused it?\",\"answer\":\"Renin increased at -40 mmHg, when both central venous and arterial pulse pressure decreased, indicating reduced inhibition from both low- and high-pressure baroreceptors.\"}]","Influence of Low and High Pressure Baroreceptors on Plasma Renin Activity in Humans - Abstract and Study Findings | PDF",71]