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It focuses on substances such as mannoheptulose, β-carotene, resveratrol, steviol glycosides, and curcumin, which may enhance insulin sensitivity, limit oxidative stress, and support pancreatic β-cell function. Promising synergy with conventional agents like metformin is discussed, alongside mechanisms including AMPK activation and GLUT4 upregulation, while emphasizing the need for further clinical research on dosing and long-term 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\nMarta Pelczy ´nska 1, Starosta Szymon 2, Michał Konieczny 2, Hubert Ba˛czyk 2, Jakub Szyszko 2, Krzysztof Cholewa 2 and Paweł Bogda ´nski 1, *  \nAcademic Editor: Sin-Chung Li  \nReceived: 31 October 2025  \nRevised: 15 December 2025  \nAccepted: 19 December 2025  \nPublished: 23 December 2025  \nCopyright: © 2025 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license.  \n1 Department of Treatment of Obesity, Metabolic Disorders and Clinical Dietetics, Poznan University of Medical Sciences, 49 Przybyszewskiego Street, 60-355 Poznan, Poland; [mpelczynska@ump.eu.pl](mpelczynska@ump.eu.pl)  \n[2](2 Faculty of Medicine)[ Faculty of Medicine](2 Faculty of Medicine), [Poznan University of Medical Sciences](Poznan University of Medical Sciences), [70 Bukowska Street](70 Bukowska Street), [60-812 Poznan](60-812 Poznan), [Poland](Poland); [91423@student.ump.edu.pl](91423@student.ump.edu.pl) (S.S.); [91285@student.ump.edu.pl](91285@student.ump.edu.pl) (M.K.); [91169@student.ump.edu.pl](91169@student.ump.edu.pl) (H.B.); [91448@student.ump.edu.pl](91448@student.ump.edu.pl) (J.S.); [91836@student.ump.edu.pl](91836@student.ump.edu.pl) (K.C.)  \n* [Correspondence: pbogdanski@ump.edu.pl](Correspondence: pbogdanski@ump.edu.pl)  \nAbstract  \nGlycemic control disorders, including insulin resistance (IR) and type 2 diabetes (T2D), represent a major global health challenge. Although existing therapeutic strategies demonstrate effectiveness regarding glycemic control and reduction in diabetes-associated mortality, they are often associated with limited patient tolerance and adherence. Consequently, thereis growing interest in natural bioactive compounds that may support glycemic regulation while potentially posing a lower risk of adverse effects in ongoing therapy. The objective of this review is to evaluate the potential of selected natural substances in the context of blood glucose regulation. The analysis encompasses data from in vitro, in vivo, and clinical studies on compounds such as mannoheptulose, β-carotene, resveratrol, steviol glycosides, and curcumin. These agents have demonstrated the ability to modulate key metabolic pathways, enhance tissue insulin sensitivity, reduce oxidative stress, and support pancreatic β-cell function. Particularly promising effects have been observed when some of these compounds are combined with conventional antidiabetic medications, such as metformin. The review also highlights relevant molecular mechanisms, including activation of the AMP-activated protein kinase (AMPK) pathway, increased expression of glucose transporter type 4 (GLUT4), and modulation of gene expression related to insulin sensitivity. Despite encouraging findings, further clinical research is necessary to determine optimal dosages, therapeutic protocols, and the long-term safety of these substances inhuman populations. Natural bioactive compounds may thus represent a valuable adjunct to current strategies for managing glycemic disorders.  \nKeywords: glycemic control; bioactive compounds; mannoheptulose; β-carotene; resveratrol; steviosides; curcumin  \n1. Introduction  \nDisorders of glycemic control represent a significant health issue affecting both older and younger populations. As the prevalence of glycemic disorders increases, there is also a rising number of deaths associated with T2D, partly due to the limitations of current therapeutic strategies regarding patient adherence and tolerance, with epidemiological projections suggesting that the number of adult individuals with carbohydrate disorders would reach as many as 700 million by 2045 . T2D is characterized by impaired pancreatic β-cell function, leading to insufficient insulin secretion and elevated peripheral blood glucose  \nlevels. It is often exacerbated by coe","cbCait7KfZM4l4h1","https://ap.wps.com/l/cbCait7KfZM4l4h1","pdf",688885,35,"English","# Abstract\n# Keywords\n# 1. Introduction\n## Insulin resistance and type 2 diabetes overview\n## Dietary factors, obesity, and caloric restriction\n## Caloric restriction mimetics and natural bioactive compounds\n## Review scope and complementary role of CRMs","[{\"question\":\"What health conditions does the review focus on?\",\"answer\":\"It addresses glycemic control disorders, specifically insulin resistance and type 2 diabetes, and the challenges they pose to global health.\"},{\"question\":\"Which natural bioactive compounds are evaluated?\",\"answer\":\"The review analyzes mannoheptulose, β-carotene, resveratrol, steviol glycosides, and curcumin, drawing on evidence from experimental and clinical studies.\"},{\"question\":\"How might these compounds influence blood glucose control?\",\"answer\":\"They are described as modulators of metabolic pathways that can enhance insulin sensitivity, reduce oxidative stress, and support pancreatic β-cell function, including via AMPK activation and increased GLUT4 expression.\"}]","Influence of Certain Natural Bioactive Compounds on Glycemic Control - A Narrative Review | PDF",1790773169,88]