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This study investigates how brain metastases affect classification, treatment decisions, and outcomes in extracranial oligometastasis. Using analysis of 7,000 oncologic PET scans and concurrent brain MRI, 106 eligible patients were evaluated, including predictors for transition from oligo- to polymetastatic states.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/influence-of-brain-metastases-on-the-classification-treatment-and-outcome-of-patients-with-extracranial-oligometastasis-a-single-center-cross-sectional-analysis/331466/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/influence-of-brain-metastases-on-the-classification-treatment-and-outcome-of-patients-with-extracranial-oligometastasis-a-single-center-cross-sectional-analysis/331466.png","ImageObject",300,407,{"name":92,"@type":93},"Skyler","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-23","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":39},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What was the purpose of analyzing brain metastases in extracranial oligometastasis patients?","Question",{"text":112,"@type":113},"The study aimed to determine how brain metastases influence the classification, treatment approaches, and clinical outcomes of patients with extracranial oligometastatic disease.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How were patients identified and evaluated in the study?",{"text":117,"@type":113},"A total of 7,000 oncologic PET scans were analyzed to identify extracranial oligometastatic disease (≤5 intra- or extra-cranial metastases). Concurrent brain MRI quantified intracranial tumor burden.",{"name":119,"@type":110,"acceptedAnswer":120},"What did the study find about outcomes after brain metastases occur?",{"text":121,"@type":113},"Brain metastases drove a transition from extracranial oligometastatic to whole-body polymetastatic disease in 45% of patients. Median overall survival was 28 months for the oligometastatic subgroup versus 10 months for the polymetastatic subgroup.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},331466,1790158914,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":39,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":52,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144,"preview_page_count":4},2336464648746,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","Christ et al. Radiation Oncology (2024) 19:148 [https://doi.org/10.1186/s13014-024-02542-2](https://doi.org/10.1186/s13014-024-02542-2)  \nRadiation Oncology  \nRESEARCH Open Access  \nInfluence of brain metastases on the    \nclassification, treatment, and outcome of patients with extracranial oligometastasis:  \na single-center cross-sectional analysis  \nSebastian M. Christ 1*, Gabriel W. Thiel2, Philip Heesen2, Siyer Roohani3, Michael Mayinger 1, Jonas Will mann 1, Maiwand Ahmadsei 1, Urs J. Muehlematter4, Alexander Maurer4, Josef A. Buchner5, Jan C. Peeken5, Rifaquat Rahman6, Ayal Aizer6, Emilie Le Rhun7,8, Nicolaus Andratschke 1, Michael Weller7, Martin Huel lner4 and Matthias Guckenberger 1  \nAbstract  \nBackground and introduction Increasing evidence suggests that a subgroup of patients with oligometastatic cancer might achieve a prolonged disease-free survival through local therapy for all active cancer lesions. Our aims are to investigate the impact of brain metastases on the classification, treatment, and outcome in these patients. Materials and methods We analyzed a total of 7,000 oncological positron emission tomography scans to identify patients with extracranial oligometastatic disease (defined as ≤ 5 intra-or extra-cranial metastases) . Concurrent magnetic resonance imaging brain was assessed to quantify intracranial tumor burden. We investigated the impact of brain metastases on oligometastatic disease state, therapeutic approaches, and outcome. Predictors for transitioning from oligo-to polymetastatic states were evaluated using regression analysis.  \nResults A total of 106 patients with extracranial oligometastases and simultaneous brain metastases were identified, primarily originating from skin or lung/pleura cancers (90%, n = 96) . Brain metastases caused a transition from an extracranial oligometastatic to a whole-body polymetastatic state in 45%(n = 48) of patients. While oligometastatic patients received systemic therapy (55% vs. 35%) more frequently and radiotherapy for brain metastases was more often prescribed to polymetastatic patients (44% vs. 26%), the therapeutic approach did not differ systematically between both sub-groups. The oligometastatic sub-group had a median overall survival of 28 months compared to 10 months in the polymetastatic sub-group (p \u003C 0. 01) .  \nConclusion In patients with brain metastases, a low total tumor burden with an oligometastatic disease state remained a significant prognostic factor for overall survival. Presence of brain metastases should therefore not serve as exclusion criterion for clinical trials in the field of oligometastatic disease. Moreover, it underscores the importance of considering a multimodality treatment strategy in oligometastatic cancer patients.  \nKeywords Oligometastasis, Brain metastasis, Treatment paradigms  \n*Correspondence: Sebastian M. Christ  \nsebastian.christ@usz.ch  \nFull list of author information is available at the end of the article  \n© The Author(s) 2024. Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit [http://](http://)[ ](http://)","cbCaiuUpdU8Smx3B","https://ap.wps.com/l/cbCaiuUpdU8Smx3B","pdf",1499525,"English","# Abstract\n# Introduction and background\n## Brain metastases epidemiology and prognosis\n## Intracranial tumor burden and survival\n## Quality-of-life and local therapies\n## Oligometastatic disease hypothesis and uncertainty","[{\"question\":\"What was the purpose of analyzing brain metastases in extracranial oligometastasis patients?\",\"answer\":\"The study aimed to determine how brain metastases influence the classification, treatment approaches, and clinical outcomes of patients with extracranial oligometastatic disease.\"},{\"question\":\"How were patients identified and evaluated in the study?\",\"answer\":\"A total of 7,000 oncologic PET scans were analyzed to identify extracranial oligometastatic disease (≤5 intra- or extra-cranial metastases). Concurrent brain MRI quantified intracranial tumor burden.\"},{\"question\":\"What did the study find about outcomes after brain metastases occur?\",\"answer\":\"Brain metastases drove a transition from extracranial oligometastatic to whole-body polymetastatic disease in 45% of patients. Median overall survival was 28 months for the oligometastatic subgroup versus 10 months for the polymetastatic subgroup.\"}]","Influence of brain metastases on the classification, treatment, and outcome of patients with extracranial oligometastasis - a single-center cross-sectional analysis | PDF",1789993361,25]