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Dietary patterns can shift inflammatory status, so this study assessed whether the inflammatory potential of an individual’s usual diet relates to mortality risk. Dietary Inflammatory Index (DII) scores were derived from repeated food-frequency questionnaire data (1992, 1994, 1996) and analyzed as continuous and quartile-group variables using Cox proportional hazards models. In 1440 adults aged 25–75 in Australia, a more pro-inflammatory diet increased all-cause mortality and other-cause mortality, and greater DII scores were linked to elevated cardiovascular mortality in younger participants and increased cancer mortality across multiple age ranges.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/inflammatory-potential-of-diet-and-mortality-in-australian-adults-research-findings/341224/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/inflammatory-potential-of-diet-and-mortality-in-australian-adults-research-findings/341224.png","ImageObject",300,407,{"name":92,"@type":93},"Hazel","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-01","2026-09-22",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",11,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"How was the inflammatory potential of diet measured in the study?","Question",{"text":113,"@type":114},"Inflammatory potential was quantified using the Dietary Inflammatory Index (DII) calculated from repeated food-frequency questionnaire data collected in 1992, 1994, and 1996.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"What outcomes were used to evaluate mortality associations?",{"text":118,"@type":114},"All-cause mortality was assessed, and mortality was also analyzed separately for cardiovascular disease (CVD), cancer, and other causes between 1992 and 2022.",{"name":120,"@type":111,"acceptedAnswer":121},"What did the study find about pro-inflammatory diets and mortality risk?",{"text":122,"@type":114},"Participants with the most pro-inflammatory diet had higher risk of all-cause mortality and other-cause mortality. Higher DII scores were also associated with increased CVD mortality in people under 55 and increased cancer mortality in age groups including ≤55 and 56–65.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},341224,1790127470,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":44,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},137441390410,"https://ap-avatar.wpscdn.com/avatar/2000252f4ab5702993?_k=1776741390130283984","Public Health Nutrition: 27(e129), 1–9 doi:10 . 1017/S1368980024000909  \nInflammatory potential of diet and mortality in Australian adults  \nAzam Majidi 1,2, Maria Celia B Hughes2, Imogen K Webb3, Kyoko Miura2,4 and Jolieke C van der Pols2,3, *  \n1Gynaecological Cancers Group, Population Health Program, QIMR Berghofer Medical Research Institute, Brisbane, Australia: 2Cancer and Population Studies Group, Population Health Program, QIMR Berghofer Medical Research Institute, Brisbane, Australia: 3Queensland University of Technology (QUT), Faculty of Health, School of Exercise and Nutrition Sciences, Brisbane QLD 4059, Australia: 4School of Biomedical Sciences, Faculty of Medicine, University of Queensland, Brisbane, Australia  \nSubmitted 30 December 2022: Final revision received 30 January 2024: Accepted 21 February 2024  \nAbstract  \nObjective: Inflammation is implicated in chronic diseases including cancer and CVD, which are major causes of mortality. Diet can influence inflammation status. We therefore examined whether the inflammatory potential of a person’s diet is associated with mortality.  \nDesign: The inflammatory potential of the usual diet was assessed by calculating Dietary Inflammatory Index (DII) scores from repeated FFQ data (collected in 1992, 1994 and 1996), placing each participant’s diet on a continuum from anti-to pro-inflammatory. DII scores were analysed as a continuous variable and as categories by creating quartile groups. Death registry data were used to ascertain all-cause mortality and separately mortality from CVD, cancers and other causes between 1992 and 2022 . Cox proportional hazard regression analysis was used to calculate adjusted hazard ratios (HR) with 95 % CI, comparing higher and lowest quartile groups, or HR change per one DII unit increase.  \nSetting: Nambour, Australia.  \nParticipants: A community-based sample of 1440 adults aged 25–75 years. Results: During follow-up, 488 participants died, including 188 from CVD, 151 from cancer and 170 from other causes. Participants in the most pro-inflammatory diet group were at increased risk of all-cause mortality (HRQ4 v. Q1 = 1·55; 95 % CI 1·19, 2·03; P \u003C 0·001) and other-cause mortality (HRQ4 v. Q1 = 1·69; 95 % CI 1·12, 2·54; P 0·01) . A one-unit increase in DII score was associated with a 36 % increased risk of CVD among those younger than 55 years of age (HR for a one-unit increase in DII score 1·36, 95 % CI 1·04, 1·78) . The risk of cancer mortality was also increased for those with a more pro-inflammatory diet in age ≤ 55 years (HR for a one-unit increase in DII score 1·20, 95 % CI 1·02, 1·40) and age 56–65 years (HR for a oneunit increase in DII score 1·11, 95 % CI 1·00, 1·23) .  \nConclusions: A pro-inflammatory diet increases the risk of all-cause mortality. Our results support the promotion of anti-inflammatory diets to help promote longevity.  \nKeywords Inflammation Diet  \nMortality Prospective study CVD  \nCancer  \nChronic low-grade inflammation has been implicated in many chronic diseases, including cancer(1), CVD(2) and type 2 diabetes(3) . Diet has the potential to influence systemic inflammatory status(4) . For instance, n-3 fatty acids from fish can have anti-inflammatory and immune function effects(5) . Dietary fibre can also have anti-inflammatory effects, possibly mediated by the intestinal microbiome(6) . In contrast, SFA have pro-inflammatory effects(7) . Thus, a person’s diet can contain a mix of pro- and antiinflammatory foods and nutrients.  \nThe overall inflammatory potential of a person’s diet can be summarised by calculating a summary score, such as the Dietary Inflammatory Index(DII)(8) . The underlying basis for this index consists of evidence of associations between specific foods or nutrients and systemic inflammation. A growing number of studies have investigated associations between DII and mortality(9–14) . A recent umbrella review of previous systematic reviews, evaluating health outcomes associated with adherence t","cbCaiq5Awl6liTMa","https://ap.wps.com/l/cbCaiq5Awl6liTMa","pdf",333193,"English","# Abstract\n## Objective\n## Design\n## Setting and participants\n## Results\n## Conclusions\n# Methods\n## Study sample","[{\"question\":\"How was the inflammatory potential of diet measured in the study?\",\"answer\":\"Inflammatory potential was quantified using the Dietary Inflammatory Index (DII) calculated from repeated food-frequency questionnaire data collected in 1992, 1994, and 1996.\"},{\"question\":\"What outcomes were used to evaluate mortality associations?\",\"answer\":\"All-cause mortality was assessed, and mortality was also analyzed separately for cardiovascular disease (CVD), cancer, and other causes between 1992 and 2022.\"},{\"question\":\"What did the study find about pro-inflammatory diets and mortality risk?\",\"answer\":\"Participants with the most pro-inflammatory diet had higher risk of all-cause mortality and other-cause mortality. Higher DII scores were also associated with increased CVD mortality in people under 55 and increased cancer mortality in age groups including ≤55 and 56–65.\"}]","Inflammatory potential of diet and mortality in Australian adults - Research findings | PDF",1790041016,23]