[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-374025-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-374025-en":131},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","incredible-use-of-plant-derived-bioactives-as-anticancer-agents","Incredible use of plant-derived bioactives as anticancer agents","","Cancer remains a major global health concern, with persistent gaps in therapy development despite advances in cancer treatment and control. This review highlights naturally derived anticancer drugs from plant resources, including alkaloids, glycosides, terpenes, terpenoids, flavones, and polyphenols. Plant-derived substances act through antiproliferative activity, cytotoxicity, apoptosis, angiogenesis inhibition, and cell-cycle arrest, engaging pathways such as STAT-3, PI3K/Akt, Ras/MAP-kinase, and JNK. The work synthesizes evidence from literature on anti-cancer potential, mechanisms of action, and clinical trials of 144 bioactive compounds and synthetic analogues, supporting plant-derived bioactives as anticancer agents.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/incredible-use-of-plant-derived-bioactives-as-anticancer-agents/374025/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/incredible-use-of-plant-derived-bioactives-as-anticancer-agents/374025.png","ImageObject",300,407,{"name":42,"@type":43},"Patrick","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-11-02","2026-09-23",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",15,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What mechanisms do plant-derived bioactives use against cancer cells?","Question",{"text":63,"@type":64},"They can show antiproliferative activity, cytotoxicity, induce apoptosis, inhibit angiogenesis, and cause cell-cycle arrest. They also affect signaling through pathways such as STAT-3, PI3K/Akt, Ras/MAP-kinase, and JNK.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"Which examples of plant-derived compounds are highlighted for anticancer potential?",{"text":68,"@type":64},"The text mentions capsaicin, ouabain, and lycopene targeting the STAT-3 pathway, as well as epigallocatechin gallate and emodin targeting JNK. It also lists berberine, evodiamine, lycorine, and astragalin with activity through PI3K/Akt and Ras/MAP-kinase pathways.",{"name":70,"@type":61,"acceptedAnswer":71},"How does the review organize evidence in its study scope?",{"text":72,"@type":64},"After a literature review, it includes anti-cancer potential, mode of action, and clinical trials of 144 bioactive compounds and their synthetic analogues, aiming to support development of plant-derived anticancer agents.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},374025,1790241076,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,110,115,120,123,127],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":108,"slug":109},7,40,"healthcare",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":112,"show_sort_weight":113,"slug":114},8,"Research & Report",30,"research-report",{"id":116,"doc_module":4,"doc_module_name":25,"category_name":117,"show_sort_weight":118,"slug":119},9,"Religion & Spirituality",20,"religion-spirituality",{"id":118,"doc_module":4,"doc_module_name":25,"category_name":121,"show_sort_weight":118,"slug":122},"World Cup","world-cup",{"id":124,"doc_module":4,"doc_module_name":25,"category_name":125,"show_sort_weight":124,"slug":126},10,"Lifestyle","lifestyle",{"id":128,"doc_module":4,"doc_module_name":25,"category_name":129,"show_sort_weight":97,"slug":130},19,"General","general",{"code":4,"msg":82,"data":132},{"doc_id":79,"user_id":133,"nickname":42,"user_avatar":134,"doc_module":4,"category_id":107,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":140,"language":141,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":142,"faqs":143,"seo_title":144,"seo_description":12,"update_tm":145,"read_time":146},549758146520,"https://ap-avatar.wpscdn.com/avatar/80002397d8c0411e94?_k=1775819394049821470","RSC Advances  \nREVIEW  \nCite this: RSC Adv., 2025, 15, 1721  \nReceived 14th July 2024  \nAccepted 31st December 2024 DOI: 10.1039/d4ra05089d[rsc.li/rsc-advances](rsc.li/rsc-advances)  \nIncredible use of plant-derived bioactives as anticancer agents  \nKiran Kangra,a Saloni Kakkar,a Vineet Mittal,a Virender Kumar,b Navidha Aggarwal,c Hitesh Chopra,d Tabarak Malik  *ef and Vandana Garg*a  \nCancer is a major global concern. Despite considerable advancements in cancer therapy and control, there are still large gaps and requirements for development. In recent years, various naturally occurring anticancer drugs have been derived from natural resources, such as alkaloids, glycosides, terpenes, terpenoids, flavones, and polyphenols. Plant-derived substances exhibit their anticancer potential through antiproliferative activity, cytotoxicity, apoptosis, angiogenesis and cell cycle arrest. Natural compounds can affect the molecular activity of cells through various signaling pathways, like the cell cycle pathway, STAT-3 pathway, PI3K/Akt, and Ras/MAP-kinase pathways. Capsaicin, ouabain, and lycopene show their anticancer potential through the STAT-3 pathway in breast, colorectal, pancreatic, lung, cervical, ovarian and colon cancers. Epigallocatechin gallate and emodin target the JNK protein in skin, breast, and lung cancers, while berberine, evodiamine, lycorine, and astragalin exhibit anticancer activity against breast, liver, prostate, pancreatic and skin cancers and leukemia through the PI3K/Akt and Ras/MAP-kinase pathways. In vitro/in vivo investigations revealed that secondary metabolites suppress cancer cells by causing DNA damage and activating apoptosis-inducing enzymes. After a meticulous literature review, the anti-cancer potential, mode of action, and clinical trials of 144 bioactive compounds and their synthetic analogues are included in the present work, which could pave the way for using plant-derived bioactives as anticancer agents.  \n1 Introduction  \nAmong the non-communicable diseases, cancer is the second most life-threatening disease a􀀁er cardiovascular diseases.1 It is caused by a combination of genetic factors, environmental stress on cellular activity,2 obesity, poor diet, excessive alcohol intake, smoking, and vitamin B12 de􀀁ciency.3 According to Sung et al., transitional cases (64%) would increase signi􀀁cantly more than transitioned cases (32%), reaching 28.4 million cases globally in 2040, with an increase of 47% cases from 2020. Approximately 10 million people would die from cancer in 2024, out of which approximately 19.3 million would be new cases.4 According to the site of occurrence, there are 131 different types of cancers, including skin cancer, lung cancer, oral cancer, and breast  \naDepartment of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, 124001, India. E-mail: [kirankangra90@gmail.com](kirankangra90@gmail.com); drsaloni.pharma@mdurohtak. [ac.in](ac.in); [drvineet.pharma@mdurohtak.ac.in](drvineet.pharma@mdurohtak.ac.in); [drvandana.pharma@mdurohtak.ac.in](drvandana.pharma@mdurohtak.ac.in)[ ](drvandana.pharma@mdurohtak.ac.in)bCollege of Pharmacy, Pandit Bhagwat Dayal Sharma University of Health Sciences,  \nRohtak, 124001, India. E-mail: [sachdeva.virender5@gmail.com](sachdeva.virender5@gmail.com)  \ncMM College of Pharmacy, Maharishi Markandeshwar (Deemed to be University), Mullana, Ambala 133207, Haryana, India  \ndDepartment of Biosciences, Saveetha School of Engineering, Saveetha Institute of Medical and Technical Sciences, Chennai 602105, Tamil Nadu, India  \neDepartment of Biomedical Sciences, Jimma University, Jimma, Ethiopia. E-mail: [tabarak.malik@ju.edu.et](tabarak.malik@ju.edu.et)  \nfDivision of Research & Development, Lovely Professional University, Phagwara, Punjab-144411, India  \ncancer.5 It is predicted that there would be 2.3 million more cases of female breast cancer (11.7%), followed by lung (11.4%), colorectal (10.1%), prostate (7.3%), and stomach (5.6%) cancers. Different typ","cbCaie3NlwXgYBax","https://ap.wps.com/l/cbCaie3NlwXgYBax","pdf",1570664,26,"English","# Review\n## 1 Introduction\n### 1.1 Pathophysiology of cancer","[{\"question\":\"What mechanisms do plant-derived bioactives use against cancer cells?\",\"answer\":\"They can show antiproliferative activity, cytotoxicity, induce apoptosis, inhibit angiogenesis, and cause cell-cycle arrest. They also affect signaling through pathways such as STAT-3, PI3K/Akt, Ras/MAP-kinase, and JNK.\"},{\"question\":\"Which examples of plant-derived compounds are highlighted for anticancer potential?\",\"answer\":\"The text mentions capsaicin, ouabain, and lycopene targeting the STAT-3 pathway, as well as epigallocatechin gallate and emodin targeting JNK. It also lists berberine, evodiamine, lycorine, and astragalin with activity through PI3K/Akt and Ras/MAP-kinase pathways.\"},{\"question\":\"How does the review organize evidence in its study scope?\",\"answer\":\"After a literature review, it includes anti-cancer potential, mode of action, and clinical trials of 144 bioactive compounds and their synthetic analogues, aiming to support development of plant-derived anticancer agents.\"}]","Incredible use of plant-derived bioactives as anticancer agents | PDF",1790201043,66]