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Analyses used a 10-year exposure lag model and a separate cumulative exposure model.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/research-report/","Research & Report",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/increasing-rates-of-early-onset-luminal-a-breast-cancers-correlate-with-binge-drinking-patterns-brief-report/332623/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/increasing-rates-of-early-onset-luminal-a-breast-cancers-correlate-with-binge-drinking-patterns-brief-report/332623.png","ImageObject",300,407,{"name":42,"@type":43},"River Wang","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-11-12","2026-09-21",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",10,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What study question was addressed in this brief report?","Question",{"text":63,"@type":64},"It assessed whether alcohol consumption, particularly binge drinking, is correlated with female breast cancer diagnosed under 40 years old.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How were alcohol exposures analyzed relative to diagnosis?",{"text":68,"@type":64},"The study used a lag model with exposure measured 10 years before cancer diagnosis and also conducted a separate cumulative 10-year exposure analysis.",{"name":70,"@type":61,"acceptedAnswer":71},"Which breast cancer subtype showed an association with binge drinking?",{"text":72,"@type":64},"Binge drinking was associated with increased rates of early-onset Luminal A breast cancer in both models, and with early-onset Luminal B in the cumulative model.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},332623,1790462911,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,111,115,120,123,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":108,"show_sort_weight":109,"slug":110},7,"Healthcare",40,"healthcare",{"id":112,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":113,"slug":114},8,30,"research-report",{"id":116,"doc_module":4,"doc_module_name":25,"category_name":117,"show_sort_weight":118,"slug":119},9,"Religion & Spirituality",20,"religion-spirituality",{"id":118,"doc_module":4,"doc_module_name":25,"category_name":121,"show_sort_weight":118,"slug":122},"World Cup","world-cup",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":55,"slug":125},"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":97,"slug":129},19,"General","general",{"code":4,"msg":82,"data":131},{"doc_id":79,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":112,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":97,"language":139,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":12,"update_tm":143,"read_time":144,"preview_page_count":4},1099514067438,"https://ap-avatar.wpscdn.com/avatar/100002539ee87300030?x-image-process=image/resize,m_fixed,w_180,h_180&k=1780474512215547542","Chen et al. Breast Cancer Research (2024) 26:145 Breast Cancer Research  \n[https://doi.org/10.1186/s13058-024-01894-7](https://doi.org/10.1186/s13058-024-01894-7)  \nBRIEF REPORT Open Access  \nIncreasing rates of early-onset Luminal Abreast cancers correlate with binge drinking patterns  \nJianjiu Chen 1, Rebecca Kehm 1,2, Wan Yang 1,2 and Mary Beth Terry 1,2,3*  \nAbstract  \nBackground Breast cancer (BC) rates have been increasing in young women in the U. S. Alcohol is an established risk factor for breast cancer and has been consistently associated with hormone receptor positive cancers, the type of breast cancer that has been increasing the fastest in young women. Given these trends, we conducted an ecological study to examine whether alcohol consumption, and specifically binge drinking trends, were correlated with female breast cancer diagnosed under 40 years of age using breast cancer data from the Surveillance, Epidemiology, and End Results (SEER) Cancer Registry. We accounted for a latent period before cancer diagnosis by using exposure 10 years before the outcome (lag model); we also conducted a separate cumulative analysis of 10-year aggregate exposure. Findings Moderate (Incidence Rate Ratio (IRR) = 1 . 05, 95% Confidence Interval (CI) = 1 .02–1. 07) and heavy (IRR = 1 . 05, 95% CI = 1 .02–1. 07)(≥ 1 and ≥ 2 drinks/day, respectively) alcohol consumption were each associated with Luminal A breast cancer but not the other molecular subtypes. Binge drinking was associated with an increased rate of early-onset Luminal A BC in both the 10-year lag model (IRR = 1 . 06, 95% CI = 1.02 to 1. 11) and the cumulative model (IRR = 1 . 05, 95% CI = 1 .02–1. 07) . Binge drinking was also associated with early-onset Luminal B BC in the cumulative model (IRR = 1 . 04, 95% CI = 1 .01–1. 07), but not associated with ERBB2-enriched or triple negative early-onset BC in either model.  \nConclusion These trends support the hypothesis that one reason for the increase in early-onset breast cancer is from increased alcohol intake including binge drinking.  \nKeywords Breast cancer, Alcohol, Binge drinking, Early onset breast cancer, Luminal A  \n*Correspondence:  \nMary Beth Terry  \n[mt146@columbia.edu](mt146@columbia.edu)  \n1Department of Epidemiology, Mailman School of Public Health, Columbia University Irving Medical Center, Columbia University, New York, NY 10032, USA  \n2Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, Columbia University, New York, NY 10032, USA  \n3722 West 168th Street, Room 1607, New York, NY 10032, USA  \nBackground  \nAlcohol is an established risk factor for breast cancer (BC) and is recognized as such by the International Agency for Research on Cancer (IARC) as well as a risk factor for colorectal cancer, liver cancer, esophageal cancer, oral pharyngeal cancer and head and neck cancer [1, 2]. Epidemiological data supporting the role of alcohol in carcinogenesis have existed for decades (see, e.g., a metaanalysis for BC and alcohol intake in 1988) [3]. Organizations like the American Association of Clinical Oncology and the American Public Health Association have called for provider training [4], and labelling and other awareness campaigns [5], particularly for common cancers like  \n© The Author(s) 2024. Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the materi","cbCaisggnmBe76wv","https://ap.wps.com/l/cbCaisggnmBe76wv","pdf",1124757,"English","# Background\n## Study approach and exposure models\n# Findings\n## Alcohol consumption and molecular subtypes\n## Binge drinking and early-onset Luminal A and Luminal B\n# Conclusion\n## Support for the alcohol-binge drinking hypothesis","[{\"question\":\"What study question was addressed in this brief report?\",\"answer\":\"It assessed whether alcohol consumption, particularly binge drinking, is correlated with female breast cancer diagnosed under 40 years old.\"},{\"question\":\"How were alcohol exposures analyzed relative to diagnosis?\",\"answer\":\"The study used a lag model with exposure measured 10 years before cancer diagnosis and also conducted a separate cumulative 10-year exposure analysis.\"},{\"question\":\"Which breast cancer subtype showed an association with binge drinking?\",\"answer\":\"Binge drinking was associated with increased rates of early-onset Luminal A breast cancer in both models, and with early-onset Luminal B in the cumulative model.\"}]","Increasing rates of early-onset Luminal A breast cancers correlate with binge drinking patterns - brief report | PDF",1789998943,13]