[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-376303-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-376303-en":131},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","increased-skin-autofluorescence-predicts-future-cancer-development","Increased skin autofluorescence predicts future cancer development","","Skin glycation assessed by skin autofluorescence (SAF) via an AGE reader has been linked to higher risks of type 2 diabetes, cardiovascular disease, and CVD- and cancer-related mortality. Using the Lifelines Cohort Study in Northern Netherlands participants with and without T2D, researchers evaluated time to new cancer diagnosis with Cox proportional hazards models adjusted for confounders. In 77,961 cancer-free individuals followed for a median of 11.5 years, higher SAF predicted increased overall cancer incidence, with stronger male associations and cancer-site specific signals.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/increased-skin-autofluorescence-predicts-future-cancer-development/376303/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/increased-skin-autofluorescence-predicts-future-cancer-development/376303.png","ImageObject",300,407,{"name":42,"@type":43},"Aldword","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-30","2026-09-24",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",13,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What does the study use to assess tissue glycation?","Question",{"text":63,"@type":64},"Tissue glycation is assessed through skin autofluorescence (SAF) measured using an AGE reader.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How did the researchers evaluate the link between SAF and cancer?",{"text":68,"@type":64},"They analyzed time to a new cancer diagnosis in the Lifelines Cohort Study using Cox proportional hazards models adjusted for confounders.",{"name":70,"@type":61,"acceptedAnswer":71},"Did higher SAF remain associated with cancer after adjustments?",{"text":72,"@type":64},"Yes. After adjusting for age, sex, waist circumference, body mass index, smoking exposure, diabetes status, and metabolic syndrome, the association between SAF and cancer incidence remained significant.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},376303,1790309382,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,110,115,120,123,127],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":108,"slug":109},7,40,"healthcare",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":112,"show_sort_weight":113,"slug":114},8,"Research & Report",30,"research-report",{"id":116,"doc_module":4,"doc_module_name":25,"category_name":117,"show_sort_weight":118,"slug":119},9,"Religion & Spirituality",20,"religion-spirituality",{"id":118,"doc_module":4,"doc_module_name":25,"category_name":121,"show_sort_weight":118,"slug":122},"World Cup","world-cup",{"id":124,"doc_module":4,"doc_module_name":25,"category_name":125,"show_sort_weight":124,"slug":126},10,"Lifestyle","lifestyle",{"id":128,"doc_module":4,"doc_module_name":25,"category_name":129,"show_sort_weight":97,"slug":130},19,"General","general",{"code":4,"msg":82,"data":132},{"doc_id":79,"user_id":133,"nickname":42,"user_avatar":134,"doc_module":4,"category_id":107,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":124,"language":140,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":12,"update_tm":144,"read_time":145},2336478940917,"https://ap-avatar.wpscdn.com/davatar_6f874abed73319feea01a86fa6f0fab8","Boersma etal. BMC Cancer (2025) 25:1375 BMC Cancer  \n[https://doi.org/10.1186/s12885-025-14801-w](https://doi.org/10.1186/s12885-025-14801-w)  \nRESEARCH Open Access  \nIncreased skin autofluorescence predicts future cancer development  \nHenderikus E. Boersma 1,2, Grigory Sidorenkov3, Andries J. Smit2, Andrew D. Paterson4,5, Bert van der Vegt6, Bruce H. R. Wolffenbuttel 1*, Melanie M. van der Klauw 1 and Geertruida [H. de](H. de) Bock3  \nAbstract  \nTissue glycation, assessed through skin autofluorescence (SAF) using an AGE reader, is linked to an increased  \nrisk of type 2 diabetes (T2D), cardiovascular disease (CVD), as well as mortality from both CVD and cancer. It was also suggested that higher SAF be linked to a greater incidence of cancer. We aimed to evaluate the relationship between SAF and the time to a new cancer diagnosis in the Lifelines Cohort Study, a population-based study in the Northern Netherlands, in participants with and without T2D. Initial participants’ screening was performed between 2006 and 2013. Detailed pathology diagnoses were obtained from the Dutch Nationwide Pathology Databank (Palga) and linked to Lifelines data up to March 2023. We performed Cox proportional hazards analyses adjusted for confounders to investigate the relationship between SAF and cancer incidence. A total of 77,961 participants (75,678 without T2D; 42% males; mean age 43 ± 12 years and 2,283 with T2D; 53% males; mean age 56 ± 12 years), who were free of cancer, were followed for a median of 11.5 years. Cumulative cancer incidence was 10. 7% in males and 12. 5% in females without diabetes, and 23. 6% and 20. 2% in males and females with T2D, respectively. SAF was significantly linked to an increased cancer incidence (HR 2. 36, 95% CI 2.26–2.45, p \u003C 0. 001) in the entire cohort. This relationship was significantly stronger in males than in females (HR 3. 13, 95% CI 2.95–3. 33, p \u003C 0.001 vs. 1. 96, 95% CI 1.86–2. 07, p \u003C 0. 001) . After adjusting for age, sex, waist circumference, body mass index, pack-years of smoking and presence of diabetes and metabolic syndrome, the association between SAF and cancer remained significant (HR 1. 11, 95% CI 1.05–1. 17, p \u003C 0. 001) . Sensitivity analyses for incident cancers diagnosed more than 2 years after baseline Lifelines screening and incident cancer after skin cancer exclusion yielded similar results. Especially lung, oesophageal and urinary tract cancer (all p \u003C 0. 001) and ovarian, female genital and liver cancer (p \u003C 0. 05) were associated with increased SAF. Similarly, higher SAF was linked to increased cancer incidence in people with T2D (HR 1. 76, 95% CI 1.50–2. 06, p \u003C 0. 001) . This relationship was no longer statistically significant after adjusting for age and sex (HR 1. 07, 95% CI 0.89–1. 29) or for all confounders (HR 1. 07, 95% CI 0.86–1. 32) . We conclude that, alongside its previously established application in evaluating the risk of future diabetes, CVD, as well as cause-specific mortality in people without diabetes, higher SAF measurements are linked to a slightly higher incidence of cancer.  \n*Correspondence:  \nBruce H. R. Wolffenbuttel  \n[bwo@umcg.nl](bwo@umcg.nl)  \n1Department of Endocrinology, University of Groningen, University Medical Center Groningen, Hanzeplein 1, P. O. Box 30001, HPC AA31, Groningen 9700 RB, the Netherlands  \n2Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands  \n3Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands  \n4Program in Genetics and Genome Biology, Hospital for Sick Children, Toronto, ON, Canada  \n5Divisions of Biostatistics and Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada  \n6Department of Pathology & Medical Biology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands  \n© The Author(s) 2025. Open Access This article is lice","cbCaivDGKt7NBR1V","https://ap.wps.com/l/cbCaivDGKt7NBR1V","pdf",1468168,"English","# Abstract\n## Introduction\n## Methods and Analysis\n## Results and Findings\n## Conclusion","[{\"question\":\"What does the study use to assess tissue glycation?\",\"answer\":\"Tissue glycation is assessed through skin autofluorescence (SAF) measured using an AGE reader.\"},{\"question\":\"How did the researchers evaluate the link between SAF and cancer?\",\"answer\":\"They analyzed time to a new cancer diagnosis in the Lifelines Cohort Study using Cox proportional hazards models adjusted for confounders.\"},{\"question\":\"Did higher SAF remain associated with cancer after adjustments?\",\"answer\":\"Yes. After adjusting for age, sex, waist circumference, body mass index, smoking exposure, diabetes status, and metabolic syndrome, the association between SAF and cancer incidence remained significant.\"}]","Increased skin autofluorescence predicts future cancer development | PDF",1790218136,25]