[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-403693-105":59,"doc-detail-403693-en":131},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":124,"head_meta":126,"extra_data":128,"updated_unix":130},105,"en","increased-risk-of-erosive-gastritis-using-oral-sulfate-tablet-bowel-preparation-a-retrospective-single-center-cohort-study","Increased Risk of Erosive Gastritis Using Oral Sulfate Tablet Bowel Preparation: A Retrospective Single-Center Cohort Study","","Study background addresses FDA-approved oral sulfate tablet (OST) bowel preparation for colonoscopy, marketed as more convenient than polyethylene glycol (PEG), while acknowledging warning labels for mucosal ulceration risk in inflammatory bowel disease (IBD) and sporadic post-marketing reports. This retrospective single-center cohort compared adult erosive gastritis occurrence after same-day esophagogastroduodenoscopy and colonoscopy between matched OST and PEG groups. Results show higher rates of gastric ulcers and erosions with OST; no clear difference in lesion locations. Conclusion supports OST-associated increased erosive gastritis risk and calls for prospective randomized mechanism-focused studies.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/increased-risk-of-erosive-gastritis-using-oral-sulfate-tablet-bowel-preparation-a-retrospective-single-center-cohort-study/403693/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/increased-risk-of-erosive-gastritis-using-oral-sulfate-tablet-bowel-preparation-a-retrospective-single-center-cohort-study/403693.png","ImageObject",300,407,{"name":92,"@type":93},"asba","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-02","2026-09-27",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",11,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What was the main objective of the retrospective cohort study?","Question",{"text":113,"@type":114},"To assess the occurrence of erosive gastritis in adults who received oral sulfate tablet (OST) bowel preparation compared with those who received polyethylene glycol (PEG) prior to same-day esophagogastroduodenoscopy (EGD) and colonoscopy.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"How were patients allocated to OST versus PEG groups?",{"text":118,"@type":114},"A single-center blinded retrospective study matched 177 patients who received OST with 219 patients who received PEG, based on available demographic, procedural, and pathology information.",{"name":120,"@type":111,"acceptedAnswer":121},"What did the study find about gastric ulcers and erosions?",{"text":122,"@type":114},"The OST group had a significantly higher incidence of both gastric ulcers (13.6% vs. 2.3%, P \u003C 0.001) and gastric erosions (16.9% vs. 5.0%, P \u003C 0.001) compared with the PEG group.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},403693,1790872383,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":19,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":52,"preview_page_count":4},3985747872567,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","Short Communication Gastroenterol Res. 2025;18(4):202-205  \nIncreased Risk of Erosive Gastritis Using Oral Sulfate Tablet Bowel Preparation: A Retrospective Single-Center Cohort Study  \nTara Alleyasina, e, Jeffrey Nguyena, Natalie A. Savinia, Nabil El Hage Chehadeb, Leah Puglisic,  \nQuan Nhua, b, d, Stuti Jaiswala, Laura Nicholsona, Emily Singhb  \nAbstract  \nBackground: In 2020, the Food and Drug Administration approved an oral sulfate tablet (OST) containing sodium sulfate, magnesium sulfate, and potassium chloride as a colonoscopy preparation that is more palatable and convenient than polyethylene glycol (PEG) with comparable efficacy. There is a precautionary warning regarding potential risk of mucosal ulcerations in patients with inflammatory bowel disease (IBD), but post-marketing reports describing gastritis and gastric ulceration have been sporadically reported, and the occurrence of gastric erosive disease in non-IBD patients has not been extensively documented. This study aimed to assess the occurrence of erosive gastritis in adult patients who received OST bowel preparation compared to patients who received PEG prior to same-day esophagogastroduodenoscopy (EGD) and colonoscopy.  \nMethods: A single-center, blinded, retrospective study was conducted of adults who underwent same-day EGD and colonoscopy. A total of 177 patients who received OST were matched with 219 patients who received PEG. Data collection involved a detailed review of the patients’ demographics, procedural, and pathology reports.  \nResults: The OST group demonstrated a significantly higher incidence of both gastric ulcers (13.6% vs. 2.3%, P-value \u003C 0.001) and erosions (16.9% vs. 5.0%, P-value \u003C 0.001) compared to the PEG group. There was no statistically significant difference between the locations of erosions and ulcers between groups.  \nManuscript submitted April 18, 2025, accepted June 9, 2025 Published online June 18, 2025  \naDepartment of Internal Medicine, Scripps Clinic/Green Hospital, San Diego, CA, USA  \nbDepartment of Gastroenterology and Hepatology, Scripps Clinic/Green Hospital, San Diego, CA, USA  \ncDepartment of Research and Development, Scripps Health, San Diego, CA, USA  \ndDepartment of Immunology & Microbiology, Scripps Research, La Jolla, CA, USA  \neCorresponding Author: Tara Alleyasin, Department of Internal Medicine, Scripps Clinic/Green Hospital, San Diego, CA, USA.  \nEmail: [alleyasin.tara@scrippshealth.org](alleyasin.tara@scrippshealth.org)  \ndoi: [https://doi.org/10.14740/gr2045](https://doi.org/10.14740/gr2045)  \nConclusion: The use of OST bowel preparation prior to colonoscopy is associated with increased incidence of erosive gastritis compared to PEG inpatients undergoing EGD and colonoscopy on the same day at our center. Prospective, randomized studies are needed to definitively establish the risks associated with OST and to evaluate the mechanism by which it may increase the occurrence of mucosal injury.  \nKeywords: Oral sulfate tablet; Gastric ulcers; Gastric erosions; Bowel preparation  \nIntroduction  \nColonoscopy remains the gold standard for screening colon cancer as it allows for direct visualization and intervention upon pre-malignant and cancerous lesions [1] . Historically, the procedure required a high-volume bowel preparation involving 2 - 4 L of polyethylene glycol (PEG) to cleanse fecal matter for adequate assessment of the colonic mucosa. The PEG preparation process has often been cited by patients asthe least tolerable aspect of a colonoscopy [2] . Various alternatives have been developed, and in 2020, the Food and Drug Administration approved an oral, poorly absorbed sulfate salt tablet (OST) composed of sodium sulfate, magnesium sulfate, and potassium chloride as an alternative to high-volume bowel preparations. A single-blind multicenter study enrolled 1,500 adult patients and demonstrated that the OST was comparable to PEG in terms of bowel cleansing efficacy, with no major reported adverse effects [3] . ","cbCaievT0S5z63pJ","https://ap.wps.com/l/cbCaievT0S5z63pJ","pdf",820401,"English","# Abstract\n## Background\n## Methods\n## Results\n## Conclusion\n# Introduction\n# Table 1: Baseline Demographics and H. pylori Status","[{\"question\":\"What was the main objective of the retrospective cohort study?\",\"answer\":\"To assess the occurrence of erosive gastritis in adults who received oral sulfate tablet (OST) bowel preparation compared with those who received polyethylene glycol (PEG) prior to same-day esophagogastroduodenoscopy (EGD) and colonoscopy.\"},{\"question\":\"How were patients allocated to OST versus PEG groups?\",\"answer\":\"A single-center blinded retrospective study matched 177 patients who received OST with 219 patients who received PEG, based on available demographic, procedural, and pathology information.\"},{\"question\":\"What did the study find about gastric ulcers and erosions?\",\"answer\":\"The OST group had a significantly higher incidence of both gastric ulcers (13.6% vs. 2.3%, P \\u003c 0.001) and gastric erosions (16.9% vs. 5.0%, P \\u003c 0.001) compared with the PEG group.\"}]","Increased Risk of Erosive Gastritis Using Oral Sulfate Tablet Bowel Preparation: A Retrospective Single-Center Cohort Study | PDF",1790542551]