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Cardiac metastasis is rare and frequently asymptomatic, which contributes to underdiagnosis and limits full understanding of disease extent. This case reports a woman with advanced breast carcinoma who showed no clinical or imaging evidence of cardiac involvement; autopsy after death revealed metastatic carcinoma infiltrating the myocardium and epicardium.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/incidental-cardiac-metastasis-in-breast-carcinoma-case-report/465284/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/incidental-cardiac-metastasis-in-breast-carcinoma-case-report/465284.png","ImageObject",300,407,{"name":92,"@type":93},"Valentina","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-30",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",15,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"Why is incidental cardiac metastasis difficult to detect in breast cancer?","Question",{"text":113,"@type":114},"Cardiac metastasis is rare and often clinically silent, with no overt symptoms, and may be overlooked in routine clinical evaluations or not apparent on imaging.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"What did the autopsy reveal in the reported case?",{"text":118,"@type":114},"A complete autopsy found metastatic carcinoma infiltrating the myocardium and epicardium without gross cardiac abnormalities, while histological and immunohistochemical results confirmed the tumor’s breast carcinoma origin.",{"name":120,"@type":111,"acceptedAnswer":121},"What clinical and imaging findings were present before cardiac evaluation?",{"text":122,"@type":114},"The patient had dyspnea and imaging showed pleural effusions and diffuse sclerotic lesions consistent with metastatic disease; subsequent cardiac evaluation with TTE and ECG showed no abnormalities, and earlier imaging reported no cardiac findings.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},465284,1791123481,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":39,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":46,"preview_page_count":4},13056703020460,"https://ap-avatar.wpscdn.com/avatar/be000253dac470eee5d?_k=1778207105932848923","Case Report  \nIncidental Cardiac Metastasis in Breast Carcinoma  \nYaomin Chen, Haibo Wang, Zhiyan Fu * and Ellen Elizabeth Connor *  \nAcademic Editor: Gustavo Baldassarre  \nReceived: 11 November 2025  \nRevised: 10 December 2025  \nAccepted: 23 December 2025  \nPublished: 25 December 2025  \nCopyright: © 2025 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license.  \nDepartment of Pathology, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA; [ychen3@lsuhsc.edu](ychen3@lsuhsc.edu) (Y.C.); [hwang6@lsuhsc.edu](hwang6@lsuhsc.edu) (H.W.)  \n* Correspondence: [zfu@lsuhsc.edu](zfu@lsuhsc.edu) (Z.F.); [econno@lsuhsc.edu](econno@lsuhsc.edu) (E.E.C.)  \nAbstract  \nBackground and Clinical Significance: Metastatic breast cancer is a major global health burden, with common metastatic sites including the bones, lungs, liver, and brain. Cardiac metastasis is rare and often clinically silent, leading to underdiagnosis. Recognizing cardiac involvement, even when asymptomatic, is important for understanding the full extent of disease and ensuring optimal patient care. Case Presentation: We report the case of a woman with advanced breast carcinoma who showed no clinical or imaging evidence of cardiac involvement throughout the course of her illness. Following her death from progressive metastatic disease, an autopsy revealed metastatic carcinoma infiltrating the myocardium and epicardium without gross cardiac abnormalities. Histological and immunohistochemical analysis confirmed the tumor’s origin from breast carcinoma. Conclusions: This case illustrates the potential for clinically occult cardiac metastasis in breast cancer and underscores the importance of pathological examination in detecting hidden metastatic sites. The absence of cardiac symptoms or imaging abnormalities highlights the diagnostic challenge of this rare manifestation and the need for greater awareness in managing advanced malignancies.  \nKeywords: breast carcinoma; cardiac metastasis; autopsy; histological examination  \n1. Introduction  \nBreast cancer is the most frequently diagnosed malignancy and remains the leading cause of cancer-related mortality among women worldwide [1] . When metastatic, it commonly spreads to the bones, lungs, liver, and brain [2] . While cardiac metastasis is considered rare and often overlooked in routine clinical evaluations, postmortem studies have demonstrated that cardiac involvement is more frequent than previously appreciated [3] . These metastases may affect any layer of the heart, including the pericardium, myocardium, or endocardium, and can result in complications such as arrhythmias, heart failure, or pericardial effusion [4,5] . Despite the potential severity, most cardiac metastases remain clinically silent, without overt symptoms, and are often identified incidentally during imaging or autopsy examinations [6] . The under-recognition of cardiac metastasis in patients with advanced breast cancer can pose a diagnostic challenge. However, its identification holds significant clinical importance. Awareness of this potential involvement is essential, particularly in patients presenting with unexplained cardiac symptoms or during the evaluation of disseminated malignancies. This report presents a case of cardiac metastasis secondary to breast carcinoma, identified at autopsy in a patient who exhibited no clinical signs suggestive of cardiac involvement. It highlights the silent nature of cardiac metastases and the role of pathology in uncovering such occult metastases and empha-  \nsizes the importance of maintaining awareness of cardiac involvement in disseminated malignancies for comprehensive evaluation and management.  \n2. Case Presentation  \nA 50-year-old African American woman with a six-month history of a right breast mass was diagnosed with invasive breast carcinoma of no special type","cbCaiiwtYnggHhQG","https://ap.wps.com/l/cbCaiiwtYnggHhQG","pdf",12807068,"English","# Abstract\n# Introduction\n# Case Presentation","[{\"question\":\"Why is incidental cardiac metastasis difficult to detect in breast cancer?\",\"answer\":\"Cardiac metastasis is rare and often clinically silent, with no overt symptoms, and may be overlooked in routine clinical evaluations or not apparent on imaging.\"},{\"question\":\"What did the autopsy reveal in the reported case?\",\"answer\":\"A complete autopsy found metastatic carcinoma infiltrating the myocardium and epicardium without gross cardiac abnormalities, while histological and immunohistochemical results confirmed the tumor’s breast carcinoma origin.\"},{\"question\":\"What clinical and imaging findings were present before cardiac evaluation?\",\"answer\":\"The patient had dyspnea and imaging showed pleural effusions and diffuse sclerotic lesions consistent with metastatic disease; subsequent cardiac evaluation with TTE and ECG showed no abnormalities, and earlier imaging reported no cardiac findings.\"}]","Incidental Cardiac Metastasis in Breast Carcinoma - Case Report | PDF",1790769434]