[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-338342-105":59,"doc-detail-338342-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","incidence-rates-and-time-trends-of-pancreatic-cancer-in-the-golestan-province-northeastern-iran-2006-2019","Incidence Rates and Time Trends of Pancreatic Cancer in the Golestan Province, Northeastern Iran, 2006-2019","","Pancreatic cancer (PC) is a highly malignant disease with poor prognosis, while Iran has experienced rising incidence and a mortality increase over recent decades. This cross-sectional analysis evaluates temporal variations and incidence of PC in Golestan province from 2006 to 2019 using the Golestan Population-Based Cancer Registry. Age-standardized incidence rates are computed with the World standard population, and trends are quantified via Poisson regression and EAPC. Results indicate overall growth, higher rates in men and urban residents, and increasing incidence from 2006 to 2019.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/incidence-rates-and-time-trends-of-pancreatic-cancer-in-the-golestan-province-northeastern-iran-2006-2019/338342/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/incidence-rates-and-time-trends-of-pancreatic-cancer-in-the-golestan-province-northeastern-iran-2006-2019/338342.png","ImageObject",300,407,{"name":92,"@type":93},"Sage","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-28","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":52},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What was the study purpose regarding pancreatic cancer in Golestan province?","Question",{"text":112,"@type":113},"To assess temporal variations and incidence trends of pancreatic cancer in Golestan province over 2006–2019.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How were incidence rates calculated in the study?",{"text":117,"@type":113},"Age-standardized incidence rates were calculated using the World standard population and reported per 100,000 persons-year, with comparisons across sexes and residence using Poisson regression (IRR).",{"name":119,"@type":110,"acceptedAnswer":120},"What main trends and subgroup differences were found?",{"text":121,"@type":113},"Pancreatic cancer incidence increased from 2006 to 2019, with higher age-standardized rates in males than females and higher rates in urban than rural populations.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},338342,1790075160,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":52,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":39,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":46},687197207057,"https://ap-avatar.wpscdn.com/davatar_29158cc5080c5b710cf443261637dec0","ARCHIVES OF  \nArch Iran Med. September 2024;27(9):486-493  IRANIAN  \ndoi 10 .34172/aim.31168 [http://journalaim.com](http://journalaim.com MEDICINE)[ MEDICINE](http://journalaim.com MEDICINE)  \nOriginal Article   \nIncidence Rates and Time Trends of Pancreatic Cancer in the Golestan Province, Northeastern Iran, 2006-2019  \nSajjad Kaabe1\\# ID , Taghi Amiriani1\\# ID , Mehrdad Teimoorian2,1* ID , Sima Besharat1,3* ID , Faezeh Salamat1, Susan  \nHasanpour-Heidari1, SeyyedMehdi Sedaghat4, Hamideh Sadeghzadeh4, Gholamreza Roshandel1  \n1Golestan Research Center of Gastroenterology and Hepatology, Golestan University of Medical Sciences, Gorgan, Iran 2Stem Cell Research Center, Golestan University of Medical Sciences, Gorgan, Iran  \n3Clinical Research Development Unit (CRDU), Sayad Shirazi Hospital, Golestan University of Medical Sciences, Gorgan, Iran  \n4 Deputy of Public Health, Golestan University of Medical Sciences, Gorgan, Iran  \nOpen Access  \nAbstract  \nBackground: Pancreatic cancer (PC) is one of the most malignant cancers with a poor prognosis. Despite advances in the diagnosis and management of PC, the survival rate remains low. In Iran, the incidence of PC is increasing, with mortality rates nearly doubling over the past 25 years. Therefore, this study was designed to assess the temporal variations and incidence of PC in Golestan province, as a prominent hub for gastrointestinal cancers in Iran.  \nMethods: In this cross-sectional study, patient information was obtained from the Golestan Population-Based Cancer Registry (GPCR) from 2006 to 2019. We calculated age-standardized incidence rates (ASRs) using the World standard population and reported the rates per 100 000 persons-year. To compare ASRs across sexes and residence areas, incidence rate ratios (IRR) were calculated using Poisson regression models. We calculated the estimated annual percentage changes (EAPC) to assess time trends in incidence rates of PC in Golestan during the study period.  \nResults: Among a total of 560 PC new cases (mean age of 63.72 years), 46.61% were diagnosed through clinical or paraclinical methods. The crude incidence rate and ASR were 2.24 and 2.95 (95% CI: 2.70‒3.20) per 100 000 persons-year, respectively. The ASR of PC was significantly higher in males (3.78; 95% CI: 3.37‒4.19) than females (2.17; 95% CI: 1.88‒2.46) (IRR = 1.71; P \u003C 0.01) . The ASR was higher in the urban (3.23; 95% CI: 2.88‒3.58) compared to the rural population (2.65; 95% CI: 2.30‒3.00)(IRR = 1.23; P = 0.02) . The ASR of PC increased from 1.97 to 3.53 during 2006 to 2019 with an EAPC of 4.39 (95% CI: -3.56 to 12.75) . The EAPCs were 4.85% and 4.37% in women and men, respectively.  \nConclusion: Our study showed that the incidence of PC is increasing in the Golestan province. Also, the incidence rate was higher in men, elderly people, and the urban population.  \nKeywords: Golestan province, Incidence, Pancreatic cancer, Temporal variation  \nCite this article as: Kaabe S, Amiriani T, Teimoorian M, Besharat S, Salamat F, Hasanpour-Heidari S, et al. Incidence rates and time trends of pancreatic cancer in Golestan province, Northeast of Iran, 2006-2019. Arch Iran Med. 2024;27(9):486-493 . doi:  \n10.34172/aim.31168  \nReceived: April 16, 2024, Accepted: August 21, 2024, ePublished: September 1, 2024  \nIntroduction  \nPancreatic cancer (PC) is a type of cancer that ranks asthe 12th most common form of cancer globally. In 2020, an estimated 495 773 individuals were diagnosed with this disease. Unfortunately, it is also the 7th deadliest cancer in the world, with 466 000 deaths reported.1 PC is considered to be one of the most lethal forms of cancer. Despite advancement in diagnosis and treatment, the prognosis for patients remains poor, with a 5-year survival rate of only 9%. Over the past decade, the incidence and mortality rate of PC have been on the rise worldwide, regardless of gender.2 Projections based on demographic shifts suggests that by the year 2040, PC will become the se","cbCaidgD3INnaPyo","https://ap.wps.com/l/cbCaidgD3INnaPyo","pdf",1747710,"English","# Abstract\n## Background\n## Methods\n## Results\n## Conclusion\n# Introduction","[{\"question\":\"What was the study purpose regarding pancreatic cancer in Golestan province?\",\"answer\":\"To assess temporal variations and incidence trends of pancreatic cancer in Golestan province over 2006–2019.\"},{\"question\":\"How were incidence rates calculated in the study?\",\"answer\":\"Age-standardized incidence rates were calculated using the World standard population and reported per 100,000 persons-year, with comparisons across sexes and residence using Poisson regression (IRR).\"},{\"question\":\"What main trends and subgroup differences were found?\",\"answer\":\"Pancreatic cancer incidence increased from 2006 to 2019, with higher age-standardized rates in males than females and higher rates in urban than rural populations.\"}]","Incidence Rates and Time Trends of Pancreatic Cancer in the Golestan Province, Northeastern Iran, 2006-2019 | PDF",1790023142]