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A population-based Danish cohort study identified new SGA users aged 65+ during 2005–2015 and matched each user to 10 controls by age, sex, and SGA initiation date. Incident AKI within 90 days was analyzed with Cox regression adjusting for confounders. Fully adjusted results showed overall SGA risk differences were not clearly significant, with drug-specific variation and wide confidence intervals.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/incidence-of-hospital-contacts-with-acute-kidney-injury-after-initiation-of-second-generation-antipsychotics-in-older-adults-a-danish-population-based-cohort-study/512344/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/incidence-of-hospital-contacts-with-acute-kidney-injury-after-initiation-of-second-generation-antipsychotics-in-older-adults-a-danish-population-based-cohort-study/512344.png","ImageObject",300,407,{"name":92,"@type":93},"Lucas Martin","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-23","2026-10-06",true,{"@type":102,"interactionType":103,"userInteractionCount":81},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What was the primary purpose of the study?","Question",{"text":112,"@type":113},"To investigate whether acute kidney injury (AKI) is associated with second-generation antipsychotic (SGA) use in older adults, focusing on short-term incidence.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How were participants selected and matched in the cohort study?",{"text":117,"@type":113},"New SGA users aged 65+ were identified from Danish national registries during 2005–2015 and matched to 10 population controls by age, sex, and the SGA initiation date.",{"name":119,"@type":110,"acceptedAnswer":120},"What were the main findings regarding 90-day AKI risk?",{"text":121,"@type":113},"Overall, the fully adjusted hazard ratio for all SGAs was 1.43 (0.89–2.27). The risk differed by drug, with olanzapine showing a significantly increased 90-day AKI risk, quetiapine elevated but not significant, and risperidone showing no association.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},512344,1792215234,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":81,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":44,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144,"preview_page_count":4},8796095360427,"https://ap-avatar.wpscdn.com/davatar_994ba38a5ba835b3df7d355c54d3ed8d","European Journal of Clinical Pharmacology (2022) 78:1341–1349  \n[https://doi.org/10.1007/s00228-022-03339-6](https://doi.org/10.1007/s00228-022-03339-6)  \nIncidence of hospital contacts with acute kidney injury after initiation of second‑generation antipsychotics in older adults: a Danish population‑based cohort study  \nReeha Sharon1 · Theis Lange2 · Mia Aakjær1 · Sarah Brøgger Kristiansen1 · Morten Baltzer Houlind3,4,5 · Morten Andersen1  \nReceived: 28 January 2022 / Accepted: 15 May 2022 / Published online: 31 May 2022 © The Author(s) 2022  \nAbstract  \nPurpose To investigate the association between acute kidney injury (AKI) and use of second-generation antipsychotics (SGA) in older adults.  \nMethods In a population-based cohort study using Danish national registries, new users of SGAs (aged ≥ 65) were identified during 2005–2015. Each SGA user was matched to 10 population controls on age, sex, and the SGA initiation date. The outcome was incident AKI within 90 days after the index date. Cox regression was used to estimate hazard ratios (HRs) with 95% confidence intervals (CIs), adjusting for potential confounders.  \nResults In the study, 36,581 new SGA users and 365,810 controls were included. The 90-day incidence rate of AKI was 4.38 and 1.70 per 1000 person-years among SGA users and controls, respectively, corresponding to a crude HR of 2.57 (1.79–3.68) . The fully adjusted HR (aHR) was 1.43 (0.89–2.27) for all SGAs. The risk differed among individual drugs with aHRs for olanzapine 3.50 (1.20–10.23), quetiapine 1.62 (0.81–3.26), and risperidone 0.68 (0.28–1.64) . In sensitivity analyses, the aHR declined to 1.24 (0.95–1.61) at 1-year follow-up.  \nConclusions Olanzapine use was associated with a significantly increased 90-day AKI risk. For quetiapine, the risk was elevated but not significant, and risperidone had no association. CIs were wide and confounder adjustment largely impacted the estimates. Main limitations included residual confounding and incomplete recording of AKI diagnoses.  \nKeywords Second-generation antipsychotics · SGA · Olanzapine · Quetiapine · Risperidone · Acute kidney injury · AKI  \nIntroduction  \nSecond-generation antipsychotics (SGA) are used for schizophrenia, treatment-resistant depression, organic delirium or hallucinations, and maintenance therapy of behavioral and  \n* Reeha Sharon [reeha.sharon@sund.ku.dk](reeha.sharon@sund.ku.dk)  \n1 Pharmacovigilance Research Center, Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark  \n2 Section of Biostatistics, Department of Public Health, University of Copenhagen, Copenhagen, Denmark  \n3 Department of Clinical Research, Copenhagen University Hospital, Hvidovre, Denmark  \n4 The Capital Region Pharmacy, Herlev, Denmark  \n5 Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark  \npsychological symptoms in dementia in older adults, e.g. , agitation, aggression, and psychotic symptoms [1, 2] .  \nThe use of antipsychotics in older people is discouraged because of a high risk of adverse effects [3], limited evidence of efficacy [4], and extrapolated evidence from the younger population [5] . The most severe adverse effects include cerebrovascular or cardiovascular events or even death [6–8]. Drug safety warnings have been issued against the use of SGAs in older adults, particularly in dementia [2], and such warnings may have influenced prescribing practice. In Denmark, the prevalence of antipsychotic use in older adults with dementia decreased from 31 .3% in 2000 to 20.4% in 2012 [9], which is, however, still considerably high use. This continued use of antipsychotics could be due to a lack of other treatment options [3] .  \nOlder adults are at a higher risk for developing acute kidney injury (AKI) compared to younger adults, due to age-related kidney function decline, chronic kidney disease  \n(CKD) and other comorbidities, increased levels of chronic","cbCaijDbVvUaUD67","https://ap.wps.com/l/cbCaijDbVvUaUD67","pdf",1034358,"English","# Abstract\n## Purpose\n## Methods\n## Results\n## Conclusions\n# Introduction\n# Method\n## Data sources","[{\"question\":\"What was the primary purpose of the study?\",\"answer\":\"To investigate whether acute kidney injury (AKI) is associated with second-generation antipsychotic (SGA) use in older adults, focusing on short-term incidence.\"},{\"question\":\"How were participants selected and matched in the cohort study?\",\"answer\":\"New SGA users aged 65+ were identified from Danish national registries during 2005–2015 and matched to 10 population controls by age, sex, and the SGA initiation date.\"},{\"question\":\"What were the main findings regarding 90-day AKI risk?\",\"answer\":\"Overall, the fully adjusted hazard ratio for all SGAs was 1.43 (0.89–2.27). The risk differed by drug, with olanzapine showing a significantly increased 90-day AKI risk, quetiapine elevated but not significant, and risperidone showing no association.\"}]","Incidence of hospital contacts with acute kidney injury after initiation of second-generation antipsychotics in older adults - a Danish population-based cohort study | PDF",1791268983,23]