[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-332360-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-332360-en":130},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","incidence-of-brain-metastasis-according-to-patient-race-and-primary-cancer-origin-a-systematic-review","Incidence of brain metastasis according to patient race and primary cancer origin - a systematic review","","A systematic review investigates differences in the incidence and primary cancer origin of synchronous brain metastasis (sBM) across racial groups. PRISMA 2020 guided a search of PubMed and Ovid for studies from January 2000 to January 2023, with screening by three independent reviewers. Ten mainly US adult studies met inclusion criteria. Results show multiple race-specific sBM incidence patterns by primary site, while conclusions emphasize disparities requiring further research to improve equity in oncologic care.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/research-report/","Research & Report",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/incidence-of-brain-metastasis-according-to-patient-race-and-primary-cancer-origin-a-systematic-review/332360/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/incidence-of-brain-metastasis-according-to-patient-race-and-primary-cancer-origin-a-systematic-review/332360.png","ImageObject",300,407,{"name":42,"@type":43},"Ezra","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-11-03","2026-09-21",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",7,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What question does the systematic review address?","Question",{"text":63,"@type":64},"It examines differences in the incidence and primary origin of synchronous brain metastasis across racial groups with different primary cancers.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How were studies selected for inclusion?",{"text":68,"@type":64},"The review followed PRISMA 2020 and searched PubMed and Ovid (January 2000 to January 2023). Three independent reviewers screened studies reporting primary cancer sites, patient demographics including race, and synchronous BM incidence.",{"name":70,"@type":61,"acceptedAnswer":71},"What did the review find about race-specific sBM incidence patterns?",{"text":72,"@type":64},"It found higher sBM incidence proportions for specific races depending on primary cancer origin, including differences for breast, colorectal, esophageal, stomach, thyroid, lung/bronchus, malignant melanoma, renal, and other sites. These patterns varied by race.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},332360,1790199672,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,110,114,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":107,"show_sort_weight":108,"slug":109},"Healthcare",40,"healthcare",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":112,"slug":113},8,30,"research-report",{"id":115,"doc_module":4,"doc_module_name":25,"category_name":116,"show_sort_weight":117,"slug":118},9,"Religion & Spirituality",20,"religion-spirituality",{"id":117,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":117,"slug":121},"World Cup","world-cup",{"id":123,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":123,"slug":125},10,"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":97,"slug":129},19,"General","general",{"code":4,"msg":82,"data":131},{"doc_id":79,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":111,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":139,"language":140,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":12,"update_tm":144,"read_time":145,"preview_page_count":4},1099514068035,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","Journal of Neuro-Oncology (2024) 169:457–467 [https://doi.org/10.1007/s1](https://doi.org/10.1007/s1) 1060-024-04748-6  \nREVIEW  \nIncidence of brain metastasis according to patient race and primary cancer origin: a systematic review  \nDavid Gomez1 · Jeffrey J. Feng2 · Stephanie Cheok3 · Ishan Shah1 · Holly Dicharry4 · David J. Cote1 ·  \nRobert G. Briggs1 · Gage A. Guerra1 · Racheal Peterson1 · Bodour Salhia1,5 · Josh Neman1,5 · Frank Attenello1 · Frances Chow1,6 · Erion K. Musabelliu7 · Gabriel Zada1  \nReceived: 20 May 2024 / Accepted: 11 June 2024 / Published online: 19 June 2024 © The Author(s) 2024  \nAbstract  \nPurpose A systematic review was conducted to investigate differences in incidence and primary origin of synchronous brain metastasis (sBM) in varying racial groups with different primary cancers.  \nMethods Adhering to PRISMA 2020 guidelines a search was conducted using PubMed and Ovid databases for publications from January 2000 to January 2023, with search terms including combinations of“brain metastasis,” “race,” “ethnicity,” and“incidence.” Three independent reviewers screened for inclusion criteria encompassing studies clearly reporting primary cancer sites, patient demographics including race, and synchronous BM (sBM) incidence.  \nResults Of 806 articles, 10 studies comprised of mainly adult patients from the United States met final inclusion for data analysis. Higher sBM incidence proportions were observed in American Indian/Alaska native patients for primary breast (p \u003C0.001), colorectal (p = 0.015), and esophageal cancers (p = 0.024) as well as in Asian or Pacific islanders for primary stomach (p \u003C0.001), thyroid (p = 0.006), and lung/bronchus cancers (p \u003C0.001) yet higher proportions in White patients for malignant melanoma (p \u003C0.001) . Compared to White patients, Black patients had higher sBM incidence likelihood in breast cancer (OR = 1.27, p = 0.01) but lower likelihood in renal (OR = 0.46, p \u003C0.001) and esophageal cancers (OR = 0.31, p = 0.005) . American Indian/Alaska native patients had a higher sBM likelihood (OR = 3.78, p = 0.004) relative to White patients in esophageal cancer.  \nConclusions These findings reveal several comparative racial differences in sBM incidence arising from different primary cancer origins, underscoring a need for further research to explain these variations. Identifying the factors contributing to these disparities holds the potential to promote greater equity in oncological care according to cancer type.  \nKeywords Brain · Metastasis · Race · Disparities · Review · Incidence  \n􀀍 David Gomez  \n[gomezdav@usc.edu](gomezdav@usc.edu); [gomezdavid.med@gmail.com](gomezdavid.med@gmail.com)  \n1 Department of Neurosurgery Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA  \n2 Western Michigan University Homer Stryker M.D. School of Medicine, Kalamazoo, MI, USA  \n3 Department of Neurological Surgery, Medical College of Wisconsin, Milwaukee, WI, USA  \n4 LSU Health Shreveport School of Medicine, Louisiana State University, Shreveport, LA 71103, USA  \n5 Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90033, USA  \n6 Department of Neurology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA  \n7 Krembil Research Institute, University Health Network, and University of Toronto, Toronto, ON, Canada  \nIntroduction  \nBrain metastasis (BM) remains a significant clinical challenge as the leading intracranial tumor in adults, with more than 100,000 new cases diagnosed annually [1, 2] . The National Cancer Institute’s Surveillance, Epidemiology, and End Results (SEER) database reports that of 1,872,057 cancer diagnoses between 2015 and 2019, 35,986 cases of synchronous BM (sBM) defined as BM identified at diagnosis of primary cancer were identified [3] . This singular statistic provides a crucial snapshot of BM at diagnosis, but likely underrepresents","cbCaitJ1d2CiLCK2","https://ap.wps.com/l/cbCaitJ1d2CiLCK2","pdf",1478220,11,"English","# Abstract\n## Purpose\n## Methods\n## Results\n## Conclusions\n# Introduction\n# Methods","[{\"question\":\"What question does the systematic review address?\",\"answer\":\"It examines differences in the incidence and primary origin of synchronous brain metastasis across racial groups with different primary cancers.\"},{\"question\":\"How were studies selected for inclusion?\",\"answer\":\"The review followed PRISMA 2020 and searched PubMed and Ovid (January 2000 to January 2023). Three independent reviewers screened studies reporting primary cancer sites, patient demographics including race, and synchronous BM incidence.\"},{\"question\":\"What did the review find about race-specific sBM incidence patterns?\",\"answer\":\"It found higher sBM incidence proportions for specific races depending on primary cancer origin, including differences for breast, colorectal, esophageal, stomach, thyroid, lung/bronchus, malignant melanoma, renal, and other sites. These patterns varied by race.\"}]","Incidence of brain metastasis according to patient race and primary cancer origin - a systematic review | PDF",1789997846,28]