[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-379293-105":59,"doc-detail-379293-en":131},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":124,"head_meta":126,"extra_data":128,"updated_unix":130},105,"en","incidence-and-risk-factors-of-cancers-in-acromegaly-a-chinese-single-center-retrospective-study","Incidence and risk factors of cancers in acromegaly - a Chinese single-center retrospective study","","Evaluate malignancy incidence in acromegaly and determine risk factors for newly diagnosed cancers, with focus on elevated growth hormone (GH) and insulin-like growth factor-1 (IGF-1). Use a retrospective cohort of 1738 hospitalized acromegaly patients (2012–2020; mean follow-up 4.3 years) and a gender- and age-matched case-control subset (280 patients) to analyze associations between biomarkers, treatment control, and post-diagnostic cancer status. Assess cancer spectrum and quantify risk compared with the general population.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/incidence-and-risk-factors-of-cancers-in-acromegaly-a-chinese-single-center-retrospective-study/379293/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/incidence-and-risk-factors-of-cancers-in-acromegaly-a-chinese-single-center-retrospective-study/379293.png","ImageObject",300,407,{"name":92,"@type":93},"Stanley","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",13,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What is the main purpose of this study?","Question",{"text":113,"@type":114},"To evaluate malignancy incidence in acromegaly and to identify risk factors for newly diagnosed cancers, especially the roles of GH and IGF-1.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"How was the study designed?",{"text":118,"@type":114},"A retrospective cohort included 1738 hospitalized acromegaly patients from 2012 to 2020, followed for a mean of 4.3 years. A gender- and age-matched case-control study (280 patients) was used for risk factor analysis.",{"name":120,"@type":111,"acceptedAnswer":121},"Which cancers showed elevated risk in patients with acromegaly?",{"text":122,"@type":114},"Thyroid cancer and colorectal cancer had elevated risk compared with the general population, with thyroid cancer showing the highest standardized incidence ratio.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},379293,1790528770,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":140,"language":141,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":142,"faqs":143,"seo_title":144,"seo_description":67,"update_tm":145,"read_time":146},2336477405376,"https://ap-avatar.wpscdn.com/davatar_29158cc5080c5b710cf443261637dec0","Endocrine (2023) 82:368–378  \n[https://doi.org/10.1007/s12020-023-03447-y](https://doi.org/10.1007/s12020-023-03447-y)  \nIncidence and risk factors of cancers in acromegaly: a Chinese single-center retrospective study  \nTongxin Xiao1,2 ● Rui Jiao1,2 ● Shengmin Yang1 ● Yi Wang3 ● Xue Bai3 ● Jingya Zhou3 ● Ran Li1 ● Linjie Wang1 ● Hongbo Yang1 ● Yong Yao4 ● Kan Deng4 ● Fengying Gong1 ● Hui Pan1 ● Lian Duan 1 ● Huijuan Zhu 1  \nReceived: 8 April 2023 / Accepted: 1 July 2023 / Published online: 13 July 2023 © The Author(s) 2023  \nAbstract  \nPurpose To evaluate the incidence of malignancies in acromegaly and to identify risk factors for newly-diagnostic cancers, especially the excessive growth hormone (GH) and insulin-like growth factor-1 (IGF-1) .  \nMethods A retrospective cohort including 1738 consecutive hospitalized patients with acromegaly in a single referral center between 2012 and 2020 (mean follow-up 4.3 years) . A gender-and age-matched case-control study (280 patients from the cohort) was performed for risk factor analysis.  \nResults One hundred thirteen malignancies (67 diagnosed after acromegaly) were observed. The overall newly-diagnostic cancer risk of acromegaly was higher than the general population (standardized incidence ratio (SIR) 2.81; 95% CI 2.18–3.57). The risk of thyroid cancer (n = 33, SIR 21.42; 95% CI 13.74–30.08) and colorectal cancer (n = 8, SIR 3.17; 95% CI 1.37–6.25) was elevated. In the overall cohort, IGF-1 (ULN: 1.27 vs. 0.94, p = 0.057), GH (1.30 vs. 1.00 ng/ml, p = 0.12), and disease-controlled rate (34.9% vs. 45.9%, p = 0.203) at the last visit did not reach significance between patients with and without post-diagnostic cancer. In the case-control study, GH (1.80 vs. 0.90 ng/ml, p = 0.018) and IGF-1 (ULN: 1.27 vs. 0.91, p = 0.003) at the last visit were higher in patients with post-diagnostic cancers, with a lower disease-controlled rate. Elder age was a risk factor for cancer. Other metabolic comorbidities and the size of pituitary tumors were similar.  \nConclusion The risk of malignancies, especially thyroid cancer, was increased in patients with acromegaly in our center. More cancer screening should be considered when managing acromegaly, especially in patients with higher posttreatment GH and IGF-1 .  \nKeywords Acromegaly ● Malignant tumors ● Thyroid cancer ● Risk factor ● Pituitary tumors  \nIntroduction  \nAcromegaly is usually caused by growth hormone (GH) -secreting pituitary adenoma, leading to elevated GH as well as insulin-like growth factor 1 (IGF-1) levels [1] . Chronic exposure to excessive GH and IGF-1 is likely associated with several systematic comorbidities in acromegaly, including malignant and benign tumors [2] .  \n* Lian Duan [duanlianpumc@163.com](duanlianpumc@163.com)  \n* Huijuan Zhu [shengxin2004@163.com](shengxin2004@163.com)  \n1 Key Laboratory of Endocrinology of National Health Commission, Department of Endocrinology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China  \nMalignant tumors have become the first [3, 4] or second [5, 6] most common cause of death in acromegaly. However, although the latest literature review indicated a moderately increased risk of overall cancer in acromegaly [7], whether the risk of cancer increases in acromegaly remains controversial [8, 9] . Many studies suggested a higher cancer risk in acromegaly [5, 10, 11], while some population-based or multicenter studies also indicated a similar risk to the  \n2 Eight-Year Program of Clinical Medicine, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China  \n3 Department of Medical Records, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China  \n4 Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical ","cbCaivf6I8DNcXPN","https://ap.wps.com/l/cbCaivf6I8DNcXPN","pdf",665653,11,"English","# Abstract\n## Purpose\n## Methods\n## Results\n## Conclusion\n# Introduction\n## Background and controversies\n## Screening considerations and prior evidence\n# Materials and methods\n## Patients","[{\"question\":\"What is the main purpose of this study?\",\"answer\":\"To evaluate malignancy incidence in acromegaly and to identify risk factors for newly diagnosed cancers, especially the roles of GH and IGF-1.\"},{\"question\":\"How was the study designed?\",\"answer\":\"A retrospective cohort included 1738 hospitalized acromegaly patients from 2012 to 2020, followed for a mean of 4.3 years. A gender- and age-matched case-control study (280 patients) was used for risk factor analysis.\"},{\"question\":\"Which cancers showed elevated risk in patients with acromegaly?\",\"answer\":\"Thyroid cancer and colorectal cancer had elevated risk compared with the general population, with thyroid cancer showing the highest standardized incidence ratio.\"}]","Incidence and risk factors of cancers in acromegaly - a Chinese single-center retrospective study | PDF",1790234937,28]