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This 20-year retrospective cohort study evaluated CLABSI incidence and associated factors among IF-3 patients receiving OIS at a national tertiary referral center. Poisson regression identified variables linked to CLABSI, with results emphasizing clinical and psychosocial contributors to prevention.",{"@graph":14,"@context":72},[15,34,55],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/research-report/","Research & 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L, Galindo-Fraga A, et al. (2026) Incidence and factors associated with central line-associated bloodstream infection in patients with chronic intestinal failure. A 20-year retrolective cohort. PLoS One 21(1): e0340064. [https://doi](https://doi). org/10.1371/journal.pone.0340064  \nEditor: Rodney Adam, Aga Khan University Hospital Nairobi, KENYA  \nReceived: March 10, 2025  \nAccepted: December 16, 2025  \nPublished: January 6, 2026  \nCopyright: © 2026 González-Salazar et al. This is an open access article distributed under the terms of the Creative Commons Attribution  License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.  \nData availability statement: All relevant data are within the manuscript and its Supporting  Information files.  \nRESEARCH ARTICLE  \nIncidence and factors associated with central line-associated bloodstream infection inpatients with chronic intestinal failure. A 20-year retrolective cohort  \nLuis Eduardo González-Salazar1, Pedro Antonio Verdeja-Padilla2,  \nAna Luz Reyes-Ramírez1, Adriana Flores-López1, Lilia Castillo-Martínez1,  \nArturo Galindo-Fraga3, Alma Rosa Chávez-Ríos3,4, Martha Asunción Huertas-Jiménez5, Aurora Elizabeth Serralde-Zúñiga1*  \n1 Servicio de Nutriología Clínica, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, 2 Programa de Maestría y Doctorado en Ciencias Médicas, Odontológicas y de la Salud, UNAM, Mexico City, Mexico, 3 Subdirección de Epidemiología Hospitalaria y Control de la Calidad de la Atención Médica, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, 4 Clínica de Catéteres Ambulatoria, Subdirección de Epidemiología Hospitalaria y Control dela Calidad de la Atención Médica, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, 5 Subdirección de Enfermería, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico  \n* [aurora.serraldez@incmnsz.mx](aurora.serraldez@incmnsz.mx)  \nAbstract  \nBackground  \nType 3 Intestinal Failure (IF-3) is a chronic condition in which patients may require long-term Outpatient Intravenous Supplementation (OIS) to maintain hydration and nutrition, they are susceptible to catheter-related infectious complications. The present study aimed to determine the incidence of factors associated with central lineassociated bloodstream infection (CLABSI) in patients with IF-3 on OIS.  \nMethodology  \nRetrolective cohort study of patients with IF-3 undergoing OIS treated at the Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, a national tertiary care and referral center in Mexico City, between 2004 and 2024. Sociodemographic, anthropometric, biochemical, clinical, and microbiological data, including isolated pathogens, were collected. Variables associated with CLABSI incidence were determined using Poisson regression analysis.  \nResults  \nSixty patients were included, of which 31 (51 .7%) were female and 29 (48 .3%) were male. The mean age was 49.5 ± 18.1 years, and BMI was 19.8 ± 5.31kg/m2. The  \nPLOS One | [https://doi.org/10.1371/journal.pone.0340064](https://doi.org/10.1371/journal.pone.0340064) January 6, 2026 1 / 16  \nFunding: The author(s) received no specific funding for this work.  \nCompeting interests: The authors have declared that no competing interests exist.  \nprimary pathophysiological mechanism of IF-3 was short bowel syndrome (n = 23 (38 .3%)) . Twenty-seven (45%) patients developed CLABSI, resulting in 36 events over 27,200 catheter days, with an incidence rate of 1.323 per 1,000 catheter days. Fifty-seven pathogens were isolated, the most frequent being Gram-negative bacteria (52 .6%), specifically the Enterobacter cloacae complex (23 .3%) and Klebsiella oxytoca (16 .6%) . Patients ","cbCaidbNOkQCTN9v","https://ap.wps.com/l/cbCaidbNOkQCTN9v","pdf",914425,16,"English","# Abstract\n## Background\n## Methodology\n## Results\n## Conclusions\n# Introduction","[{\"question\":\"What was the study objective regarding CLABSI in IF-3 patients?\",\"answer\":\"To determine the incidence of factors associated with central line-associated bloodstream infection in patients with type 3 intestinal failure receiving outpatient intravenous supplementation.\"},{\"question\":\"How was the study conducted?\",\"answer\":\"A 20-year retrospective cohort of IF-3 patients undergoing outpatient intravenous supplementation between 2004 and 2024, collecting sociodemographic, clinical, biochemical, and microbiological data.\"},{\"question\":\"Which factors were associated with higher CLABSI incidence?\",\"answer\":\"Intestinal stomas showed a higher CLABSI incidence, and depression was associated with increased CLABSI incidence in the regression analysis.\"}]","Incidence and factors associated with central line-associated bloodstream infection in patients with chronic intestinal failure - Research article - 20-year retrolective cohort | PDF",1790710215]