[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-330313-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-330313-en":130},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","importance-of-mirna-206-in-the-animal-model-and-human-diseases-a-comprehensive-review","Importance of MiRNA-206 in the Animal Model and Human Diseases - A Comprehensive Review","","MicroRNA-206 (miR-206) is implicated in multiple human diseases, with evidence for both inhibitory and disease-promoting effects. Elevated miR-206 expression has been reported in osteoarthritis, gastric cancer, and epithelial ovarian cancer, while it contributes to breast cancer progression and avascular necrosis of the femoral head. In contrast, miR-206 levels are reduced in several malignancies including laryngeal carcinoma and hepatocellular carcinoma, and it shows stage-dependent dysregulation in amyotrophic lateral sclerosis. The review also highlights roles in neuropsychiatric disorders such as depression and proposes miR-206 as a future biomarker.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/importance-of-mirna-206-in-the-animal-model-and-human-diseases-a-comprehensive-review/330313/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/importance-of-mirna-206-in-the-animal-model-and-human-diseases-a-comprehensive-review/330313.png","ImageObject",300,407,{"name":42,"@type":43},"Lucas Martin","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-22","2026-09-21",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",6,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What roles does miR-206 play in human diseases?","Question",{"text":63,"@type":64},"miR-206 shows both inhibition effects and progression roles across multiple diseases, with expression patterns that can either increase or decrease depending on the condition and stage.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"Which diseases show reported changes in miR-206 expression?",{"text":68,"@type":64},"High expression is noted in osteoarthritis and several cancers, while down-regulation is described in laryngeal carcinoma, hepatocellular carcinoma, non-small lung cancer, and infantile hemangioma.",{"name":70,"@type":61,"acceptedAnswer":71},"How does miR-206 behave across stages of amyotrophic lateral sclerosis?",{"text":72,"@type":64},"miR-206 is up-regulated in the mild stage and then down-regulated in moderate and severe stages, suggesting double effects in disease initiation and aggravation.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},330313,1790116916,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,105,109,114,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & 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Neuropharmacology  \nWang Qi 1 and Wei Guan2,3,*  \n1Department of Pharmacology, The First People's Hospital of Yancheng, Yancheng, 224000, Jiangsu, China; 2Department of Pharmacology, Pharmacy College, Nantong University, Nantong, 226001, Jiangsu, China; 3School of Medicine, Nantong University, Nantong, China  \nAbstract: MicroRNA-206 (miR-206) is a microRNA that is involved in many human diseases, such as myasthenia gravis, osteoarthritis, depression, cancers, etc. Both inhibition effects and progression roles of miR-206 have been reported for the past few years. High expression of miR-206 was observed in patients with osteoarthritis, gastric cancer and epithelial ovarian cancer compared to normal people. The study also showed that miR-206 promotes cancer progression in breast cancer patients and avascular necrosis of the femoral head. Meanwhile, several studies have shown that expression levels of miR-206 were down-regulated in laryngeal carcinoma cell multiplication, as well as in hepatocellular carcinoma, non-small lung cancer and infantile hemangioma. Moreover, miR-206 was up-regulated in the mild stage of amyotrophic lateral sclerosis patients and then down-regulated in the moderate and severe stages, indicating that miR-206 has the double effects of starting and aggravating the disease. Inneuropsychiatric disorders, such as depression, miR-206 also plays an important role in the progression of the disease; the level of miR-206 is most highly expressed in the brains of patients with depression. In the current review, we summarize the role of miR-206 in various diseases, and miR-206 maybe developed as a new biomarker for diagnosing diseases in the near future.  \nKeywords: MiRNA, miR-206, biomarkers, human diseases, expression levels, Alzheimer’s disease.  \n1. INTRODUCTION  \nMicroRNAs (miRNAs) represent a type of endogenous, evolutionarily conserved, non-coding small RNAs, which are made up of about 20-22 nucleotides in size [1] . The first two known miRNAs were discovered over 35 years ago in the nematode Caenorhabditis elegans with the identification of the developmental regulator lin-4 and human miRNA let-7 . From then on, plenty of miRNAs have been studied by scientists in various fields, like plants, mammals and some viruses [2] . MiRNAs are derived from primary miRNA transcripts (pri-miRNAs) and high efficiency and precision excisions from imperfect stem-loop residing in the pri-miRNAs [3], which are different from other kinds of small RNAs, such as PIWI-interacting RNA (piRNA), small interfering RNA (siRNA), and transfer RNA-derived small RNA (tsRNA) [4- 6] . The great majority of miRNAs are transcribed by the DNA-dependent RNA polymerase II and processed into premiRNA composed of 70 to 100 ribonucleotides with the help of a ribonuclease III (Drosha) [7] . Finally, Dicer, another ribonuclease III, recognizes and splices it into a mature 20- 24 nucleotides (nt) miRNA [8] .  \n*Address correspondence to this author at the Department of Pharmacology, Pharmacy College, Nantong University, 19 QiXiu Road, Nantong, 226001,  \nJiangsu, China; E-mail: [guanwei88@ntu.edu.cn](guanwei88@ntu.edu.cn)  \n1875-6190/24 $65.00+.00  \nAn accumulating body of research indicates that miRNAsplay important roles in gene regulation and phenotype development by targeting messenger RNA (mRNA) transcripts. According to studies, miRNAs can potentially regulate more than 60% of human protein-coding genes [9] . Nowadays, more than 2,000 miRNAs have been illustrated to have a stronger relationship with about one-third of the genes in the human genome [10] . Moreover, miRNAs often induce gene overexpression or silencing by binding to the complementary sequences in the 3’-untranslated regions (UTRs) of targeted mRNAs, and therefore miRNAs may serve as the posttranscriptional gene regulators to strengthen or weaken the gene expression and control cel","cbCainfduNo1XyO5","https://ap.wps.com/l/cbCainfduNo1XyO5","pdf",6113159,16,"English","# Introduction\n# Methods","[{\"question\":\"What roles does miR-206 play in human diseases?\",\"answer\":\"miR-206 shows both inhibition effects and progression roles across multiple diseases, with expression patterns that can either increase or decrease depending on the condition and stage.\"},{\"question\":\"Which diseases show reported changes in miR-206 expression?\",\"answer\":\"High expression is noted in osteoarthritis and several cancers, while down-regulation is described in laryngeal carcinoma, hepatocellular carcinoma, non-small lung cancer, and infantile hemangioma.\"},{\"question\":\"How does miR-206 behave across stages of amyotrophic lateral sclerosis?\",\"answer\":\"miR-206 is up-regulated in the mild stage and then down-regulated in moderate and severe stages, suggesting double effects in disease initiation and aggravation.\"}]","Importance of MiRNA-206 in the Animal Model and Human Diseases - A Comprehensive Review | PDF",1789988122]