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Results: Cancer detection rate was 40.02%; age, PSA, prostate volume, positive mp-MRI, and sample length predicted detection (P\u003C0.05). ROC thresholds indicated minimum sample length of 11.00 mm after matching. Conclusion: Sample length is the most critical indicator for puncture quality and diagnostic accuracy in TPB.",{"@graph":14,"@context":77},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/research-report/","Research & Report",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/importance-of-biopsy-sample-length-for-cancer-diagnosis-during-trans-perineal-prostate-biopsy/332527/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/importance-of-biopsy-sample-length-for-cancer-diagnosis-during-trans-perineal-prostate-biopsy/332527.png","ImageObject",300,407,{"name":42,"@type":43},"Miles","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-31","2026-09-21",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",9,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69,73],{"name":60,"@type":61,"acceptedAnswer":62},"What was the study objective regarding biopsy sample length?","Question",{"text":63,"@type":64},"To determine the factors that establish the minimum biopsy sample length needed for accurate cancer diagnosis during trans-perineal prostate biopsy.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How many TPB cases were analyzed and what was the cancer detection rate?",{"text":68,"@type":64},"The study analyzed 1202 cases and reported a cancer detection rate of 40.02% (481/1202).",{"name":70,"@type":61,"acceptedAnswer":71},"Which factors were independently associated with cancer detection during TPB?",{"text":72,"@type":64},"Age, PSA, prostate volume, positive mp-MRI, and biopsy sample length were independent predictors of cancer detection rate (P\u003C0.05).",{"name":74,"@type":61,"acceptedAnswer":75},"What is the minimum biopsy sample length recommended by ROC analysis?",{"text":76,"@type":64},"ROC curve analysis indicated optimal thresholds of 12.25 mm before matching and 11.00 mm after propensity score matching, with 11.00 mm as the minimum value.","https://schema.org",{"og:url":32,"og:type":79,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":81,"canonical":32},"index,follow",{"doc_id":83,"site_id":7},332527,1790012767,{"code":4,"msg":86,"data":87},"success",[88,92,96,100,105,110,115,119,123,126,130],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":97,"show_sort_weight":98,"slug":99},"Exam",70,"exam",{"id":101,"doc_module":4,"doc_module_name":25,"category_name":102,"show_sort_weight":103,"slug":104},5,"Comic",60,"comic",{"id":106,"doc_module":4,"doc_module_name":25,"category_name":107,"show_sort_weight":108,"slug":109},6,"Technology",50,"technology",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":112,"show_sort_weight":113,"slug":114},7,"Healthcare",40,"healthcare",{"id":116,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":117,"slug":118},8,30,"research-report",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":121,"slug":122},"Religion & Spirituality",20,"religion-spirituality",{"id":121,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":121,"slug":125},"World Cup","world-cup",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":127,"slug":129},10,"Lifestyle","lifestyle",{"id":131,"doc_module":4,"doc_module_name":25,"category_name":132,"show_sort_weight":101,"slug":133},19,"General","general",{"code":4,"msg":86,"data":135},{"doc_id":83,"user_id":136,"nickname":42,"user_avatar":137,"doc_module":4,"category_id":116,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":138,"file_id":139,"file_url":140,"file_type":141,"file_size":142,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":55,"language":143,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":144,"faqs":145,"seo_title":146,"seo_description":12,"update_tm":147,"read_time":148,"preview_page_count":4},13056703019404,"https://ap-avatar.wpscdn.com/davatar_29158cc5080c5b710cf443261637dec0","Zhu et al. BMC Urology (2024) 24:209 [https://doi.org/10.1186/s12894-024-01596-4](https://doi.org/10.1186/s12894-024-01596-4)  \nBMC Urology  \n RESEARCH Open Access  \nImportance of biopsy sample length for cancer diagnosis during trans-perineal prostate biopsy  \nZaisheng Zhu1*, Yiyi Zhu2, Yibo Zhou1, Penfei Zhou1, Yadong Xue1 and Shengye Hu 1  \nAbstract  \nObjective To identify the factors that determine the minimum length of biopsy sample required for accurate diagnosis.  \nMaterials and methods A retrospective analysis was conducted on 1202 cases that underwent rectal ultrasoundguided trans-perineal prostate biopsy (TPB) with standardized biopsy surgical procedures and pathological evaluation. Logistic regression correlation analysis and the imbalance between groups was eliminated by propensity score matching of patients’ own factors between groups (positive group and negative group) . ROC curve optimal threshold analysis were performed to identify the independent factors associated with cancer detection rate and the minimum length of biopsy sample required for accurate diagnosis.  \nResults The study included 1202 cases that underwent standardized 8–18 needle initial puncture biopsies from June 2020 to October 2023. The cancer detection rate was 40. 02%(481/1202), with Gleason scores of 6, 7, 8, 9, and 10 in 164, 134, 107, 67, and 9 patients, respectively. The percentage of patients with clinical significance (International Society of Urological Pathology (ISUP) ≥ 2) was 65. 90%(317/481) . Multivariate analysis showed that age, prostatespecific antigen(PSA), prostate volume, positive multi-parametric magnetic resonance imaging (mp-MRI) and length of biopsy samples were significant factors (P \u003C 0. 05)。 Interestingly, biopsy sample length did not correlate  \nwith the prostate volume (Pearson correlation P = 0 . 069) . ROC curve analysis: The area under the curve AUC for sample length were 0.674 and 0.664 at before and after propensity score matching, respectively; the optimal thresholds were 12.25 mm and 11. 00mm at before and after propensity score matching, respectively.  \nConclusion The independent predictors of cancer detection rate during TPB are age, PSA, prostate volume, positive mp-MRI, and sample length. Among these, sample length is the most critical indicator affecting puncture quality, and the minimum value of biopsy sample length to be obtained is 11. 00mm.  \nKeywords Prostate tumor, Trans-perineal biopsy, Diagnosis, Biopsy sample length, Propensity score matching  \n*Correspondence: Zaisheng Zhu [zaishengzhu@126.com](zaishengzhu@126.com)  \n1 Department of Urology, Jinhua Hospital Affiliated to Zhejiang University School of Medicine, 365 East Renming Road, Jinhua, Zhejiang 321000, China  \n2 Department of Endocrinology, Affiliated Second Hospital to Zhejiang University School of Medicine, Hangzhou 310009, China  \nIntroduction  \nProstate cancer is commonly diagnosed using prostate biopsy, which involves trans-rectal ultrasound guidance, and yields a cancer detection rate of 34.1–45% [1–3]. To enhance detection rates, supplementary approaches, including additional puncture needles [2, 3], multiparametric magnetic resonance imaging (mp-MRI) [4, 5], or ultrasound fusion puncture, are often employed. Nonetheless, the mp-MRI and related fusion puncture  \n© The Author(s) 2024. Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated other","cbCaiu3IOof2NyfL","https://ap.wps.com/l/cbCaiu3IOof2NyfL","pdf",1000286,"English","# Abstract\n# Introduction\n# Materials and methods","[{\"question\":\"What was the study objective regarding biopsy sample length?\",\"answer\":\"To determine the factors that establish the minimum biopsy sample length needed for accurate cancer diagnosis during trans-perineal prostate biopsy.\"},{\"question\":\"How many TPB cases were analyzed and what was the cancer detection rate?\",\"answer\":\"The study analyzed 1202 cases and reported a cancer detection rate of 40.02% (481/1202).\"},{\"question\":\"Which factors were independently associated with cancer detection during TPB?\",\"answer\":\"Age, PSA, prostate volume, positive mp-MRI, and biopsy sample length were independent predictors of cancer detection rate (P\\u003c0.05).\"},{\"question\":\"What is the minimum biopsy sample length recommended by ROC analysis?\",\"answer\":\"ROC curve analysis indicated optimal thresholds of 12.25 mm before matching and 11.00 mm after propensity score matching, with 11.00 mm as the minimum value.\"}]","Importance of Biopsy Sample Length for Cancer Diagnosis During Trans-perineal Prostate Biopsy | PDF",1789998605,23]