[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-451155-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-451155-en":130},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","implementation-of-a-ketogenic-diet-clinic-in-mexico-a-pilot-program-in-a-resource-limited-setting","Implementation of a ketogenic diet clinic in Mexico - A pilot program in a resource-limited setting","","This study describes the implementation and outcomes of the first protocolized Ketogenic Diet Clinic (KDC) in Mexico for pediatric drug-resistant epilepsy (DRE). A retrospective analysis included 20 pediatric patients who initiated ketogenic diet therapy between July 2022 and July 2024 at a multidisciplinary KDC in a public tertiary hospital. All patients started on KDT via a structured protocol using modified regimens. At ~3 months, 50% achieved ≥50% seizure reduction and 20% achieved ≥90%; ASM dose and count generally decreased, and hospital visits declined after initiation.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/implementation-of-a-ketogenic-diet-clinic-in-mexico-a-pilot-program-in-a-resource-limited-setting/451155/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/implementation-of-a-ketogenic-diet-clinic-in-mexico-a-pilot-program-in-a-resource-limited-setting/451155.png","ImageObject",300,407,{"name":42,"@type":43},"Đào","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-30","2026-09-30",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",10,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What is the main purpose of the pilot program described in the study?","Question",{"text":63,"@type":64},"To implement and evaluate the first protocolized Ketogenic Diet Clinic (KDC) in Mexico for pediatric drug-resistant epilepsy, including feasibility and clinical outcomes.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How many pediatric patients initiated ketogenic diet therapy under the structured KDC protocol?",{"text":68,"@type":64},"Twenty patients with drug-resistant epilepsy started ketogenic diet therapy between July 2022 and July 2024.",{"name":70,"@type":61,"acceptedAnswer":71},"What seizure and treatment-burden outcomes were observed after initiation?",{"text":72,"@type":64},"At the first follow-up (~3 months), 50% achieved ≥50% seizure reduction and 20% achieved ≥90% reduction; antiseizure medication dose and count decreased in a majority of patients, and hospital visits declined after KDT initiation.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},451155,1790796639,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,110,115,120,123,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":108,"slug":109},7,40,"healthcare",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":112,"show_sort_weight":113,"slug":114},8,"Research & Report",30,"research-report",{"id":116,"doc_module":4,"doc_module_name":25,"category_name":117,"show_sort_weight":118,"slug":119},9,"Religion & Spirituality",20,"religion-spirituality",{"id":118,"doc_module":4,"doc_module_name":25,"category_name":121,"show_sort_weight":118,"slug":122},"World Cup","world-cup",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":55,"slug":125},"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":97,"slug":129},19,"General","general",{"code":4,"msg":82,"data":131},{"doc_id":79,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":107,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":111,"language":139,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":12,"update_tm":143,"read_time":118,"preview_page_count":4},1374402968488,"https://ap-avatar.wpscdn.com/davatar_29158cc5080c5b710cf443261637dec0","Epilepsy & Behavior Reports 33 (2026) 100842  \nContents lists available at ScienceDirect Epilepsy & Behavior Reports  \njournal [homepage:](homepage: www.elsevier.com/locate/ebcr)[ www.elsevier.com/locate/ebcr](homepage: www.elsevier.com/locate/ebcr)  \n| Implementation of a ketogenic diet clinic in Mexico: A pilot program in aresource-limited setting\u003Cbr>Melissa Chavez-Castillo a,* , Paloma Hurtado-Cuan b , Maria Alejandra Soto-Blanquelc , Amado Jimenez-Ruiz d , Enrique Gomez-Figueroad , Rosa Marquez-Palaciose \u003Cbr>a Pediatric Epilepsy Clinic, Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara, Jalisco, Mexico b Faculty of Medicine, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Jalisco, Mexico c Department of Clinical Nutrition, Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara, Jalisco, Mexico d Department of Neurology, Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara, Jalisco, Mexico e Department of Pediatric Neurology, Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara, Jalisco, Mexico |  |  |\n| --- | --- | --- |\n| A R T I C L E I N F O |  | A B S T R A C T |\n| Keywords:\u003Cbr>Drug-resistant epilepsy Low-income setting Ketogenic diet therapy Pediatric epilepsy |  | This study describes the implementation and outcomes of the first protocolized Ketogenic Diet Clinic (KDC) in Mexico for pediatric drug-resistant epilepsy (DRE). We conducted a retrospective analysis of 20 patients with DRE who initiated KDT between July 2022 and July 2024 in a multidisciplinary KDC at a public tertiary hospital. All patients were newly started on KDT under a structured protocol; none followed a classic 4:1 ketogenic diet, all received modified regimens. Clinical, nutritional, and socioeconomic data were collected. Seizure outcomes were categorized by percent reduction, and antiseizure medication (ASM) burden was evaluated through changes in cumulative daily dose and ASM count. Hospital admissions were recorded, and caregivers were asked about barriers to implementation. At the first follow-up visit (≈3 months), with complete data for all 20 patients, 10/20 (50 %) achieved ≥50 % seizure reduction and 4/20 (20 %) achieved ≥90 % reduction. Due to staggered recruitment, later visits included fewer patients (n = 18 and n = 14). Among the 14 patients who reached the third visit, 9/14 (64 %) achieved ≥90 % reduction. ASM dose decreased in 12/20 (60 %), and ASM count decreased in 6/20 (30 %). Hospital visits declined from 16 events the prior year to 4 after KDT initiation. Despite cultural, nutritional, educational, and access-related barriers, no patient discontinued the diet, as treatment plans were adapted to maintain feasibility. A structured KDC is feasible and clinically beneficial in a resource-limited setting. Modified KDT regimens reduced seizure burden and treatment intensity, supporting expansion of KDT programs in low-resource contexts. |\n\n1. Introduction  \nEpilepsy represents a significant global health concern, with an estimated 45.9 million individuals currently living with active epilepsy worldwide. This burden is disproportionately higher in low-and middleincome countries (LMIC), where prevalence rates may be nearly double those observed in high-income nations. It is estimated that approximately 80 % of individuals affected by epilepsy reside in LMIC [1,2].  \nMedical research has made significant progress in developing antiseizure medications (ASM), doubling the available options over the past decade. However, access to these treatments remains uneven as they are  \nnot readily available or affordable in all countries [3]. Almost 30 % of patients living with epilepsy will develop drug-resistant epilepsy (DRE). These patients require a multidisciplinary approach and often benefit from non-pharmacological treatment [4]. The KDT for epilepsy includes the classic ketogenic therapy, which typically uses a 4:1 fat-to-non-fat ratio and alternative regimens such as the ","cbCairCW91pwHa5B","https://ap.wps.com/l/cbCairCW91pwHa5B","pdf",4591576,"English","# Introduction\n## Epilepsy burden and treatment gaps in LMIC\n## Drug-resistant epilepsy and multidisciplinary care\n## Ketogenic diet therapy options\n## Rationale for implementing KDC in Mexico and resource-limited settings","[{\"question\":\"What is the main purpose of the pilot program described in the study?\",\"answer\":\"To implement and evaluate the first protocolized Ketogenic Diet Clinic (KDC) in Mexico for pediatric drug-resistant epilepsy, including feasibility and clinical outcomes.\"},{\"question\":\"How many pediatric patients initiated ketogenic diet therapy under the structured KDC protocol?\",\"answer\":\"Twenty patients with drug-resistant epilepsy started ketogenic diet therapy between July 2022 and July 2024.\"},{\"question\":\"What seizure and treatment-burden outcomes were observed after initiation?\",\"answer\":\"At the first follow-up (~3 months), 50% achieved ≥50% seizure reduction and 20% achieved ≥90% reduction; antiseizure medication dose and count decreased in a majority of patients, and hospital visits declined after KDT initiation.\"}]","Implementation of a ketogenic diet clinic in Mexico - A pilot program in a resource-limited setting | PDF",1790734494]