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The work engineers and implants adipocytes designed to outcompete tumors for nutrients, showing substantial suppression of cancer progression. Engineered adipocytes or adipose organoids significantly reduce hypoxia and angiogenesis across breast, colon, pancreas, and prostate cancers. In mouse models, transplanted modulated adipocyte organoids suppress tumor growth both near and at distal sites, and co-culture with patient-derived adipocytes further reduces growth. The study introduces adipose modulation transplantation (AMT) as a broadly applicable therapeutic strategy.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/implantation-of-engineered-adipocytes-that-outcompete-tumors-for-resources-suppresses-cancer-progression/381010/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/implantation-of-engineered-adipocytes-that-outcompete-tumors-for-resources-suppresses-cancer-progression/381010.png","ImageObject",300,407,{"name":92,"@type":93},"Emma Wilson","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",11,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What therapeutic strategy does the study propose?","Question",{"text":113,"@type":114},"The study proposes adipose modulation transplantation (AMT), using engineered adipocytes to compete with tumors for nutrients and suppress cancer progression.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"How do engineered adipocytes affect tumor microenvironment features?",{"text":118,"@type":114},"They significantly suppress cancer progression while reducing hypoxia and angiogenesis in multiple cancer settings.",{"name":120,"@type":111,"acceptedAnswer":121},"What evidence supports AMT across different cancer models?",{"text":122,"@type":114},"The authors report suppression of growth in several cancers (breast, colon, pancreas, prostate) and show that transplanted modulated adipocyte organoids can act both near and distally from tumors in mouse models.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},381010,1790448191,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":140,"language":141,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":142,"faqs":143,"seo_title":144,"seo_description":67,"update_tm":145,"read_time":146},3848291630094,"https://eur-avatar.wpscdn.com/davatar_085a072bc5b1113ac321206ff7593b45","bioRxiv preprint doi: [https://doi.org/10.1101/2023.03.28.534564](https://doi.org/10.1101/2023.03.28.534564); this version posted March 29, 2023. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made  \navailable under aCC-BY 4.0 International license.  \nImplantation of engineered adipocytes that outcompete tumors for resources suppresses cancer progression  \nHai P. Nguyen 1,2 , Rory Sheng 1,2 , Elizabeth Murray 1,2 , Yusuke Ito 1,2 , Michael Bruck3 , Cassidy Biellak 1,2 , Kelly An 1,2 , Filipa Lynce4 , Deborah A. Dillon5 , Mark Jesus M.  \nMagbanua6 , Laura A. Huppert3 , Heinz Hammerlindl7 , Laura Esserman8 , Jennifer M. Rosenbluth3,9 , Nadav Ahituv 1,2,*  \n1 Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA, USA.  \n2 Institute for Human Genetics, University of California San Francisco, San Francisco, CA, USA.  \n3 Division of Hematology/Oncology, Department of Medicine, University of California San Francisco, San Francisco, CA, USA.  \n4 Dana-Farber Cancer Institute, Harvard University, Boston, MA 02215, USA.  \n5 Department of Pathology, Brigham and Women’s Hospital, Boston, MA 02115, USA.  \n6 Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA 04158, USA.  \n7 Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA 94158, USA.  \n8 Department of Surgery, University of California, San Francisco, San Francisco, CA 94158, USA.  \n9Chan Zuckerberg Biohub – San Francisco, San Francisco, CA 94158, USA.  \n*Corresponding author: [nadav.ahituv@ucsf.edu](nadav.ahituv@ucsf.edu)  \nbioRxiv preprint doi: [https://doi.org/10.1101/2023.03.28.534564](https://doi.org/10.1101/2023.03.28.534564); this version posted March 29, 2023. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made  \navailable under aCC-BY 4.0 International license.  \nAbstract  \nTumors acquire an increased ability to obtain and metabolize nutrients. Here, we engineered and implanted adipocytes to outcompete tumors for nutrients and show that they can substantially reduce cancer progression. Growing cells or xenografts from several cancers (breast, colon, pancreas, prostate) alongside engineered human adipocytes or adipose organoids significantly suppresses cancer progression and reduces hypoxia and angiogenesis. Transplanting modulated adipocyte organoids in pancreatic or breast cancer mouse models nearby or distal from the tumor significantly suppresses its growth. To further showcase therapeutic potential, we demonstrate that co-culturing tumor organoids derived from human breast cancers with engineered patient-derived adipocytes significantly reduces cancer growth. Combined, our results introduce a novel cancer therapeutic approach, termed adipose modulation transplantation (AMT), that can be utilized for a broad range of cancers.  \nbioRxiv preprint doi: [https://doi.org/10.1101/2023.03.28.534564](https://doi.org/10.1101/2023.03.28.534564); this version posted March 29, 2023. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made  \navailable under aCC-BY 4.0 International license.  \nIntroduction  \nTumors are complex tissues composed of cancerous and non-cancerous cells in a hypoxic and nutrient-deprived microenvironment. The tumor microenvironment (TME) contains heterogeneous cell populations, including immune cells, mesenchymal support cells, and matrix components contributing to tumor growth and progression (1) . In order to survive this environment, tumors are capable of reprogramming metabolic pathways to better utilize available substrates ","cbCaipoE4YA72bRf","https://ap.wps.com/l/cbCaipoE4YA72bRf","pdf",3992975,27,"English","## Abstract\n## Introduction","[{\"question\":\"What therapeutic strategy does the study propose?\",\"answer\":\"The study proposes adipose modulation transplantation (AMT), using engineered adipocytes to compete with tumors for nutrients and suppress cancer progression.\"},{\"question\":\"How do engineered adipocytes affect tumor microenvironment features?\",\"answer\":\"They significantly suppress cancer progression while reducing hypoxia and angiogenesis in multiple cancer settings.\"},{\"question\":\"What evidence supports AMT across different cancer models?\",\"answer\":\"The authors report suppression of growth in several cancers (breast, colon, pancreas, prostate) and show that transplanted modulated adipocyte organoids can act both near and distally from tumors in mouse models.\"}]","Implantation of engineered adipocytes that outcompete tumors for resources suppresses cancer progression | PDF",1790243124,68]