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This study assessed associations between promoter polymorphisms rs243865 and rs2285053 and breast cancer risk using PCR-based RFLP in 1,232 cases and 1,232 controls. Control genotypes followed Hardy-Weinberg equilibrium, and genotype or allele distributions showed no statistically significant differences or interactions. Variant genotypes suggested a minimal, non-significant protective trend for breast cancer and TNBC.",{"@graph":69,"@context":127},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/impacts-of-matrix-metalloproteinase-2-promoter-genotypes-on-breast-cancer-risk/331232/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/impacts-of-matrix-metalloproteinase-2-promoter-genotypes-on-breast-cancer-risk/331232.png","ImageObject",300,407,{"name":92,"@type":93},"Asher","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",11,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119,123],{"name":110,"@type":111,"acceptedAnswer":112},"Which MMP-2 promoter polymorphisms were examined in this study?","Question",{"text":113,"@type":114},"The study investigated MMP-2 promoter polymorphisms rs243865 and rs2285053 to assess their association with breast cancer risk.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"How were MMP-2 genotypes analyzed?",{"text":118,"@type":114},"MMP-2 genotypes were analyzed using a PCR-based RFLP methodology in a cohort of 1,232 breast cancer cases and 1,232 controls.",{"name":120,"@type":111,"acceptedAnswer":121},"Did the genotypes rs243865 and rs2285053 significantly affect breast cancer or TNBC risk?",{"text":122,"@type":114},"No significant differences were observed in genotype distribution between cases and controls, and stratified analysis did not reveal significant associations with triple-negative breast cancer (TNBC).",{"name":124,"@type":111,"acceptedAnswer":125},"What was the overall conclusion about the impact of these genotypes?",{"text":126,"@type":114},"MMP-2 rs243865 and rs2285053 genotypes appear to have only a minimal impact on individual susceptibility to breast cancer or TNBC.","https://schema.org",{"og:url":83,"og:type":129,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":131,"canonical":83},"index,follow",{"doc_id":133,"site_id":62},331232,1790167762,{"code":4,"msg":5,"data":136},{"doc_id":133,"user_id":137,"nickname":92,"user_avatar":138,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":139,"file_id":140,"file_url":141,"file_type":142,"file_size":143,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":44,"language":144,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":145,"faqs":146,"seo_title":147,"seo_description":67,"update_tm":148,"read_time":149},687197207639,"https://ap-avatar.wpscdn.com/davatar_a8503ba1806abce46bf441b54a3ca4cd","CANCER GENOMICS & PROTEOMICS 21: 502-510 (2024) doi:10.21873/cgp.20467  \nImpacts of Matrix Metalloproteinase-2 Promoter Genotypes on Breast Cancer Risk  \nCHIH-CHIANG HUNG 1* , CHUNG-LIN TSAI2* , YU-TING CHIN3,4* , YUN-CHI WANG3,4 , CHIA-HUA LIU 1 , MENG-LIANG LIN5 , SHIH-SHUN CHEN6 , JIE-LONG HE7 , CHIA-WEN TSAI3,4 , CHEN-HSIEN SU4 , DA-TIAN BAU3,4,8 and WEN-SHIN CHANG3,4  \n1Division of Breast Surgery, Department of Surgery, Taichung Veterans General Hospital, Taichung, Taiwan, R. O. C. ;  \n2Division of Cardiac and Vascular Surgery, Cardiovascular Center, Taichung Veterans General Hospital, Taichung, Taiwan, R.O.C.;  \n3Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, R. O. C. ;  \n4Terry Fox Cancer Research Laboratory, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan, R.O.C.;  \n5Department of Medical Laboratory Science and Biotechnology, China Medical University, Taichung, Taiwan, R.O.C.;  \n6Department of Medical Laboratory Science and Biotechnology, College of Medical and Health Science, Asia University, Taichung, Taiwan, R.O.C.;  \n7Department of Post-Baccalaureate Veterinary Medicine, Asia University, Taichung, Taiwan, R. O. C. ;  \n8Department of Bioinformatics and Medical Engineering, Asia University, Taichung, Taiwan, R. O. C.  \nAbstract. Background/Aim: Matrix metalloproteinase-2 (MMP-2) has been implicated in the pathogenesis of breast cancer (BC) . However, there is limited research on the role of MMP-2 genotypes in BC risk. This study aimed to investigate the associations between two MMP-2 promoter polymorphisms, rs243865 and rs2285053, and BC risk. Materials and Methods: MMP-2 genotypes were analyzed using PCR-based RFLP methodology in a cohort comprising 1,232 BC cases and 1,232 controls. Results: Genotypic frequencies of MMP-2 rs243865 and rs2285053 in controls were consistent with Hardy-Weinberg equilibrium (p=0.3702 and 0.2036, respectively) . There were no significant  \n*These Authors contributed equally to this study.  \nCorrespondence to: Da-Tian Bau and Wen-Shin Chang, Terry Fox Cancer Research Laboratory, Department of Medical Research, China Medical University Hospital, 2 Yuh-Der Road, Taichung, 404 Taiwan, R. O. C. Tel: +886 422053366 (Ext. 5805), e-mail: [artbau2@gmail.com](artbau2@gmail.com) (Bau), [halittlemelon@hotmail.com](halittlemelon@hotmail.com) (Chang)  \nKey Words: Breast cancer, genotype, matrix metalloproteinase-2, polymorphism, triple negative breast cancer.  \nThis article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY-NC-ND) 4.0 international license ([https://creativecommons.org/licenses/by-nc-nd/4.0](https://creativecommons.org/licenses/by-nc-nd/4.0)).  \ndifferences in the distribution of rs243865 and rs2285053 genotypes between BC cases and controls (p for trend=0.1602 and 0.2170, respectively) . Variant genotypesat rs243865 and rs2285053 appeared to confer a protective effect, although not statistically significant (all p>0.05) . Similarly, the variant T allele at rs243865 and rs2285053 showed a non-significant trend towards decreased BC risk (OR=0 .84 and 0. 89, 95%CI=0 .69-1.02 and 0.78-1. 02, p=0.0811 and 0.1043, respectively) . There was no interaction observed between MMP-2 rs243865 or rs2285053 genotypes and age. Stratified analysis did not reveal significant associations between MMP-2 rs243865 or rs2285053 genotypes and triple-negative breast cancer (TNBC) (p=0.6458 and 0.8745, respectively) . Among both TNBC and non-TNBC cases, none of the variant genotypesat rs243865 or rs2285053 showed significant associations with TNBC (all p>0.05) . Conclusion: MMP-2 rs243865 andrs2285053 genotypes appear to have a minimal impact on individual susceptibility to BC or TNBC.  \nBreast cancer (BC) represents the most prevalent malignancy among women, profoundly impacting their physical and mental well-being in clinical settings. In 2020 alone, there were an alarmin","cbCaijcfq6qlRLKQ","https://ap.wps.com/l/cbCaijcfq6qlRLKQ","pdf",660031,"English","# Abstract\n## Background/Aim\n## Materials and Methods\n## Results\n## Conclusion\n# Keywords\n# Introduction\n## Breast cancer burden and TNBC features\n## Role of MMPs in tumor progression\n## MMP-2 biology and promoter polymorphisms","[{\"question\":\"Which MMP-2 promoter polymorphisms were examined in this study?\",\"answer\":\"The study investigated MMP-2 promoter polymorphisms rs243865 and rs2285053 to assess their association with breast cancer risk.\"},{\"question\":\"How were MMP-2 genotypes analyzed?\",\"answer\":\"MMP-2 genotypes were analyzed using a PCR-based RFLP methodology in a cohort of 1,232 breast cancer cases and 1,232 controls.\"},{\"question\":\"Did the genotypes rs243865 and rs2285053 significantly affect breast cancer or TNBC risk?\",\"answer\":\"No significant differences were observed in genotype distribution between cases and controls, and stratified analysis did not reveal significant associations with triple-negative breast cancer (TNBC).\"},{\"question\":\"What was the overall conclusion about the impact of these genotypes?\",\"answer\":\"MMP-2 rs243865 and rs2285053 genotypes appear to have only a minimal impact on individual susceptibility to breast cancer or TNBC.\"}]","Impacts of Matrix Metalloproteinase-2 Promoter Genotypes on Breast Cancer Risk | PDF",1789992334,23]