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A retrospective study from a multidisciplinary ALS care center in Natal, Brazil, evaluated demographic and clinical predictors of survival, focusing on weight loss percentage at diagnosis. Among 132 patients, weight loss and disease progression rate were the strongest predictors of reduced survival, with early nutritional and multidisciplinary interventions emphasized.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/impact-of-weight-loss-and-disease-progression-on-survival-in-als-insights-from-a-multidisciplinary-care-center/435912/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/impact-of-weight-loss-and-disease-progression-on-survival-in-als-insights-from-a-multidisciplinary-care-center/435912.png","ImageObject",300,407,{"name":92,"@type":93},"Finn","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",11,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What was the main objective of the study on ALS survival?","Question",{"text":113,"@type":114},"To determine how demographic and clinical characteristics relate to survival in ALS patients, emphasizing the role of weight loss percentage at diagnosis.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"How many ALS patients were included and what was the key survival finding?",{"text":118,"@type":114},"The study included 132 patients. Weight loss and the rate of disease progression were identified as the strongest predictors of reduced survival.",{"name":120,"@type":111,"acceptedAnswer":121},"Which groups showed notably reduced survival?",{"text":122,"@type":114},"Survival was notably reduced in patients aged 60 years or older, those with significant weight loss, rapid disease progression, and those submitted to gastrostomy.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},435912,1790760197,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":44,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},34359740700684,"https://ap-avatar.wpscdn.com/avatar/1f400023980c374ae676?_k=1777273430885731487","Article published online: 2025-10-15  \nOriginal Article 1  \nImpact of weight loss and disease progression on survival in ALS: insights from a multidisciplinary care center  \nMário Emílio Teixeira Dourado Junior 1 Laura Carvalheira Dourado2 Glauciane Costa Santana3 Sancha Helena de Lima Vale4 Lucia Leite-Lais4  \n1 Universidade Federal do Rio Grande do Norte, Centro de Ciências da Saúde, Departamento de Medicina Integrada, Natal RN, Brazil.  \n2 Universidade Federal do Rio Grande do Norte, Centro de Ciências da Saúde, Programa de Pós-Graduação em Nutrição, Natal RN, Brazil.  \n3 Universidade Federal do Rio Grande do Norte, Hospital Universitário Onofre Lopes, Natal RN, Brazil.  \nArq. Neuro-Psiquiatr. 2025;83(10):s00451812029 .  \nAddress for correspondence Lucia Leite-Lais (email: [lucia.leite@ufrn.br](lucia.leite@ufrn.br))  \n4 Universidade Federal do Rio Grande do Norte, Centro de Ciências da Saúde, Departamento de Nutrição, Natal RN, Brazil.  \nAbstract  \nKeywords  \n► Amyotrophic Lateral Sclerosis  \n► Weight Loss  \n► Disease Progression  \n► Nutritional Status  \n► Survival Analysis  \nBackground Amyotrophic lateral sclerosis (ALS) is a multifaceted neurodegenerative disorder with a poor prognosis. Weight loss and malnutrition emerge as significant clinical features during disease progression.  \nObjective To explore how demographic and clinical characteristics relate to survival in ALS patients, emphasizing the role of weight loss percentage at the time of diagnosis. Methods We conducted a retrospective study that used the database of a multidisciplinary ALS care center in the city of Natal, Brazil.  \nResults A total of 132 patients were included in the study. The mean age of the participants at symptom onset was of 56.9 years, and most of them were male (59.8%) . Older age, bulbar onset, and faster disease progression were associated with weight loss 􀀁 10% at diagnosis. Among 132 patients, 72% experienced death or tracheostomy, with a median survival of 34 months. Survival was notably reduced in patients aged 􀀁 60 years, those with significant weight loss, rapid disease progression, or those submitted to gastrostomy. Weight loss and the rate of disease progression were the strongest predictors of reduced survival. Potential factors relating gastrostomy with reduced survival are discussed.  \nConclusion The present study highlights the critical impact of weight loss and disease progression on survival in ALS patients, emphasizing the importance of early nutritional and clinical interventions. These findings underscore the need for comprehensive, multidisciplinary care strategies to address key prognostic factors and improve outcomes in ALS patients.  \nreceived  \nJanuary 22, 2025  \nreceived in its final form March 6, 2025  \naccepted July 27, 2025  \nDOI [https://doi.org/](https://doi.org/)[ ](https://doi.org/)10.1055/s-0045-1812029 . ISSN 0004-282X.  \nEditor-in-Chief: Ayrton Roberto Massaro.  \nAssociate Editor: Wilson Marques Jr.  \n© 2025 . The Author(s) .  \nThis is an open access article published by Thieme under the terms of the Creative Commons Attribution 4.0 International License, permitting copying and reproduction so long as the original work is given appropriate credit ([https://creativecommons.org/licenses/by/4.0/](https://creativecommons.org/licenses/by/4.0/))  \nThieme Revinter Publicações Ltda. , Rua Rego Freitas, 175, loja 1, República, São Paulo, SP, CEP 01220-010, Brazil  \n2 Weight loss and disease progression in ALS Dourado Junior et al.  \nINTRODUCTION  \nAmyotrophic lateral sclerosis (ALS) is a multifaceted neurodegenerative disorder marked by the deterioration of upper and lower motor neurons. It generally begins in adulthood, approximately at 55 to 75 years of age. It follows a progressive course, with a median survival of 􀀃 3 years after symptom onset, though life expectancy can range from months to more than 10 years. Respiratory failure predominantly accounts for mortality. The disorder exhibits clinical and genetic hete","cbCaifIMhJ5ExG05","https://ap.wps.com/l/cbCaifIMhJ5ExG05","pdf",950998,"English","# Abstract\n# Background\n# Objective\n# Methods\n## Study design and population\n## Data collection\n# Results\n# Conclusion","[{\"question\":\"What was the main objective of the study on ALS survival?\",\"answer\":\"To determine how demographic and clinical characteristics relate to survival in ALS patients, emphasizing the role of weight loss percentage at diagnosis.\"},{\"question\":\"How many ALS patients were included and what was the key survival finding?\",\"answer\":\"The study included 132 patients. Weight loss and the rate of disease progression were identified as the strongest predictors of reduced survival.\"},{\"question\":\"Which groups showed notably reduced survival?\",\"answer\":\"Survival was notably reduced in patients aged 60 years or older, those with significant weight loss, rapid disease progression, and those submitted to gastrostomy.\"}]","Impact of weight loss and disease progression on survival in ALS: insights from a multidisciplinary care center | PDF",1790675950,23]